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Your Position: Start > Protein > TRAIL R3 > TR3-H52H3

Human TRAIL R3 protein, His Tag (MALS verified)

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  • Synonym
    CD263, DCR1, DCR1-TNFR, LIT, TRAIL-R3, TRAILR3, TRID
  • Source
    Human TRAIL R3 protein, His Tag(TR3-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Pro 235 (Accession # O14798).
    Predicted N-terminus: Ala 26
  • Molecular Characterization
    TRAIL R3 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 24 kDa. The protein migrates as 43-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
TRAIL R3 SDS-PAGE

Human TRAIL R3 protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

SEC-MALS
TRAIL R3 MALS images

The purity of Human TRAIL R3 protein, His Tag (Cat. No. TR3-H52H3) is more than 90% and the molecular weight of this protein is around 35-50 kDa verified by SEC-MALS.

Bioactivity-ELISA
 TRAIL R3 ELISA

Immobilized Human TRAIL R3 protein, His Tag (Cat. No. TR3-H52H3) at 5 μg/mL (100 μL/well) can bind Human TRAIL, Mouse IgG2a Fc Tag (Cat. No. TRL-H5259) with a linear range of 0.008-0.5 μg/mL (QC tested).

  • Background
    Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C) is also known as Decoy receptor 1 (DcR1), TNF-related apoptosis-inducing ligand receptor 3 (TRAIL receptor 3 or TRAIL-R3), CD263. TNFRSF10C is a decoy receptor for TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), a member of the tumor necrosis factor (TNF) ligand family. This receptor is not capable of inducing apoptosis (lacks a cytoplasmic death domain), and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis.
  • Clinical and Translational Updates

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