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Your Position: Start > Cadherin-17

Cadherin-17

Brief Information

Name:Cadherin-17
Target Synonym:Liver-intestine cadherin,HPT-1,Intestinal peptide-associated transporter HPT-1,LI-cadherin,HPT-1 Cadherin,Cadherin 17, LI Cadherin (Liver-Intestine),HPT1,Human Intestinal Peptide-Associated Transporter HPT-1,LI Cadherin,Cadherin,Cadherin 17,Human Peptide Transporter 1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 2 Clinical

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Kat. Nr. Arten Produktbeschreibung Struktur Reinheit Merkmal
CA7-C52H3 Cynomolgus Cynomolgus Cadherin-17 / CDH17 Protein, His Tag (MALS verified)
CA7-C52H3-structure
CA7-C52H3-sds
CA7-C5253 Cynomolgus Cynomolgus Cadherin-17 / CDH17 Protein, Fc Tag (MALS verified)
CA7-C5253-structure
CA7-C5253-sds
CHEK-ATP173 Human HEK293/Human Cadherin-17 Stable Cell Line
CA7-M82F3 Mouse Biotinylated Mouse Cadherin-17 / CDH17 Protein, Fc,Avitag™ (MALS verified)
CA7-M82F3-structure
CA7-M82F3-sds
CA7-H82F9 Human Biotinylated Human Cadherin-17 / CDH17 Protein, Fc,Avitag™ (MALS verified)
CA7-H82F9-structure
CA7-H82F9-sds
CA7-M5256 Mouse Mouse Cadherin-17 / CDH17 Protein, Fc Tag (MALS verified)
CA7-M5256-structure
CA7-M5256-sds
CA7-H5258 Human Human Cadherin-17 / CDH17 Protein, Fc Tag (MALS verified)
CA7-H5258-structure
CA7-H5258-sds
CA7-M82E7 Mouse Biotinylated Mouse Cadherin-17 / CDH17 Protein, His,Avitag™ (MALS verified)
CA7-M82E7-structure
CA7-M82E7-sds
CA7-H52A9 Human Human Cadherin-17 / CDH17 Protein, Mouse IgG1 Fc Tag
CA7-H52A9-structure
CA7-H52A9-sds
CA7-C82E8 Cynomolgus Biotinylated Cynomolgus Cadherin-17 / CDH17 Protein, His,Avitag™ (MALS verified)
CA7-C82E8-structure
CA7-C82E8-sds
CA7-R52H3 Rat Rat Cadherin-17 / CDH17 Protein, His Tag (MALS verified)
CA7-R52H3-structure
CA7-R52H3-sds
CA7-H52E6 Human Biotinylated Human Cadherin-17 / CDH17 Protein, His,Avitag™ (MALS verified)
CA7-H52E6-structure
CA7-H52E6-sds
CA7-H52H3 Human Human Cadherin-17 / CDH17 Protein, His Tag
CA7-H52H3-structure
CA7-H52H3-sds
CA7-M52H5 Mouse Mouse Cadherin-17 / CDH17 Protein, His Tag (MALS verified)
CA7-M52H5-structure
CA7-M52H5-sds
ACRO Quality

Part of Bioactivity data

CHEK-ATP173-Cell-based assay
Cadherin-17 FACS

Expression analysis of human Cadherin-17 on HEK293/Human Cadherin-17 Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human Cadherin-17 Stable Cell Line or negative control cell using anti-human Cadherin-17 antibody followed by staining with FITC anti-mouse IgG antibody.

Protocol
CA7-H52H3-SPR
Cadherin-17 SPR

Anti-Cadherin-17 antibody captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human Cadherin-17, His Tag (Cat. No. CA7-H52H3) with an affinity constant of 2.9 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
CA7-C5253-ELISA
Cadherin-17 ELISA

Immobilized Cynomolgus Cadherin-17 Protein, Fc Tag (Cat. No. CA7-C5253) at 1 μg/mL (100 μL/well) can bind Anti-CDH17 antibody with a linear range of 2-63 ng/mL (QC tested).

Protocol

Synonym Name

Cadherin-17,CDH17,HPT-1,LI-cadherin

Background

Cadherin-17, also known as liver-intestine (LI) Cadherin, belongs to the cadherin family of calcium-dependent cell adhesion molecules. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CHM-2101 CDH17-CAR T; CHM-2101; CHM2101; CHM-2101 CAR-T cells Phase 2 Clinical University Of Pennsylvania Stomach Neoplasms; Pancreatic Neoplasms; Neuroendocrine Tumors; Colorectal Neoplasms; Gastrointestinal Neoplasms Details
BI-905711 BI-905711 Phase 1 Clinical Boehringer Ingelheim Gmbh Pancreatic Neoplasms; Cholangiocarcinoma; Gastrointestinal Neoplasms Details
ARB-202 ARB-202 Phase 1 Clinical Arbele Corp Liver Neoplasms; Biliary Tract Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Esophageal adenocarcinoma; Gastrointestinal Neoplasms Details
CHM-2101 CDH17-CAR T; CHM-2101; CHM2101; CHM-2101 CAR-T cells Phase 2 Clinical University Of Pennsylvania Stomach Neoplasms; Pancreatic Neoplasms; Neuroendocrine Tumors; Colorectal Neoplasms; Gastrointestinal Neoplasms Details
BI-905711 BI-905711 Phase 1 Clinical Boehringer Ingelheim Gmbh Pancreatic Neoplasms; Cholangiocarcinoma; Gastrointestinal Neoplasms Details
ARB-202 ARB-202 Phase 1 Clinical Arbele Corp Liver Neoplasms; Biliary Tract Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Esophageal adenocarcinoma; Gastrointestinal Neoplasms Details

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