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Human iPSC-Derived Liver Organoid Differentiation Kit

For research use only.

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Materials Provided
Box A(2-8°C)
IDComponentsSize
RIPO-RWM009K-C01Liver organoid Basal medium A9ml
RIPO-RWM009K-C02Liver organoid Basal medium B9ml
RIPO-RWM009K-C03Liver organoid Basal medium C13.5ml
RIPO-RWM009K-C04Liver organoid Basal medium D22.5ml
 
Box B(-20°C)
IDComponentsSize
RIPO-RWM009K-1-C01Liver organoid Supplement A1ml
RIPO-RWM009K-1-C02Liver organoid Supplement B1ml
RIPO-RWM009K-1-C03Liver organoid Supplement C-11.2ml
RIPO-RWM009K-1-C04Liver organoid Supplement C-20.3ml
RIPO-RWM009K-1-C05Liver organoid Supplement D-12ml
RIPO-RWM009K-1-C06Liver organoid Supplement D-20.5ml
  • Product Details
    Human iPSC-Derived Liver Organoid Differentiation Kit allows hESC or hiPSC to differentiate into liver organoids. Liver organoids are three-dimensional in vitro models with a cellular composition and structural organization that is representative to the human liver. This kit can produce 48 liver organoids in four steps.
  • Product Specification
    The basic medium of this kit is a serum-free, well-defined medium with minimal batch variation to which differentiation factors are added. This medium does not contain antibiotics, the addition of which may affect organoid differentiation.
  • Storage

    The unopened Box A is stable for 12 months from the date of manufacture if stored under 2-8°C.
    The unopened Box B is stable for 12 months from the date of manufacture if stored under -20°C.
    The opened kit should be stored according to components table.

*Please note that to support full process of organoid culture and maintenance, this product have to be used with Human iPSC-Derived Liver Organoid Expansion and Maintenance Medium (Cat. No.RIPO-RWM010),you can follow this link for product information.
Product Diagram
 Organoids PRODUCT DIAGRAM

Protocol Diagram of liver organoid differentiation.

Validation Data
Orgnaoid Histology
 Organoids ORGNAOID HISTOLOGY

H&E Staining of liver organoid.

Marker Expression
 Organoids MARKER EXPRESSION

The liver organoids show expression of hepatocytes (HFN4a), hepatobiliary tracts (CK19), Albumin (ALB) and vascular endothelial cell (CD31).

 Organoids MARKER EXPRESSION

Pre-mature liver organoids show liver lobules-like structure.

Organoid Activity
 Organoids ORGANOID ACTIVITY

Liver organoids show better performance than HepG2 cell line in terms of the expression of Albumin, CYP3A4, CYP1A2, CYP2C9, CYP7A1 and BSEP.

 Organoids ORGANOID ACTIVITY

Liver organoid show response to Rifampicin treatment as indication by the increase fluorescence intensity of CYP3A4.

  • Clinical and Translational Updates

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Voraussichtlicher Liefertermin für vorrätige Produkte: 2 Arbeitstage

Price(EUR) : €660.00

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