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Your Position: Start > Apolipoprotein E

Apolipoprotein E

Brief Information

Name:Apolipoprotein E
Target Synonym:APOE,Apolipoprotein E,Alzheimer Disease 2 (APOE*E4-Associated, Late Onset),Apolipoprotein E3,LDLCQ5,ApoE4,Apo-E,LPG,AD2,Apolipoproteins E
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

APE-H52E7-Cell-based assay
 Apolipoprotein E FACS

3e5 of HeLa cells were co-incubated with 50 nM Cy3-labeled LNPs-siRNA in the presence or absence of 1 μg/mL Biotinylated Human APOE4, His,Avitag (Cat. No. APE-H52E7), washed and analyzed with FACS. PE signal was used to evaluate the expression of Cy3+ HeLa cells (Routinely tested).

APE-H52E3-Cell-based assay
 Apolipoprotein E FACS

3e5 of HeLa cells were co-incubated with 50 nM Cy3-labeled LNPs-siRNA in the presence or absence of 1 μg/mL Biotinylated Human APOE3, His,Avitag (Cat. No. APE-H52E3), washed and analyzed with FACS. PE signal was used to evaluate the expression of Cy3+ HeLa cells (Routinely tested).

APE-C52H7-SPR
 Apolipoprotein E SPR

Cynomolgus TREM2, His Tag (Cat. No. TR2-C52H3) immobilized on CM5 Chip can bind Cynomolgus Apolipoprotein E Protein, His Tag (Cat. No. APE-C52H7) with an affinity constant of 7.78 μM as determined in a SPR assay (Biacore 8K) (QC tested).

APE-C52H7-SPR
 Apolipoprotein E SPR

Cynomolgus Apolipoprotein E Protein, His Tag (Cat. No. APE-C52H7) immobilized on CM5 Chip can bind Cynomolgus TREM2, His Tag (Cat. No. TR2-C52H3) with an affinity constant of 4.54 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Synonym Name

Apolipoprotein E,APOE,Apo-E

Background

APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CN-105 CN-105 Phase 2 Clinical Cerenova Cerebral Hemorrhage; Stroke Details
LX-1001 LX-1001 Phase 2 Clinical LEXEO Therapeutics Alzheimer Disease Details

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