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Immun-Checkpoint-Proteine
Immun-Checkpoint-Proteine sind Schlüsselregulatoren der Immunantwort gegen Bedrohungen und bewahren gleichzeitig die Autoimmuntoleranz. Der klassische Immun-Checkpoint besteht aus co-inhibitorischen Rezeptoren (CTLA-4, PD-1, TIGIT, LAG-3), die die T-Zell-Funktion hemmen und co-stimulatorischen Rezeptoren (GITR, 4-1BB, OX40, CD40), die die T-Zell-Aktivierung stimulieren. Forschungen zu den co-inhibitorischen Rezeptoren CTLA-4 (cytotoxic T-lymphocyte antigen 4) und PD-1 (programmed cell death protein 1) zeigten signifikant verbesserte Überlebensraten von Patienten mit metastasierten soliden Tumoren nach Hemmung dieser Rezeptorwege. Daher sind Antikörper-Medikamente gegen Immun-Checkpoints für Krebs-, Tumor- und andere Krankheitstherapeutika ein Schlüsselfaktor in der Krebstherapie.
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Co-stimulatorische Rezeptoren
Moleküle | Spezies | Tags | Konjugate | Merkmale (Verfügbare Protokolle) |
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PD-1 | Human, Mouse, Canine, Cynomolgus, Rabbit, Rat, Rhesus macaque | Fc, His, Fc & His, Fc & Avi & His, Fc & Avi, His & Avi, mFc& Avi, Twin-Strep, Llama Fc , mFc | Biotin-labeled, PE-labeled, Unconjugated | SDS-PAGE, MALS, HPLC, ELISA, BLI, SPR, |
PD-L1 | Human, Mouse, Rabbit, Canine, Cynomolgus / Rhesus macaque | Fc, His, Fc & Avi, His & Avi, Fc & Avi & His, mFc, LlamaFc, mFc& Avi, Twin-Strep | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, ELISA, BLI, SPR, |
PD-L2 | Human, Mouse | Fc, His, Fc & Avi, Avi & His, mFc | Biotin-labeled, Unconjugated | SDS-PAGE, HPLC, ELISA, SPR, BLI, , Cell based assay |
B7-H3 | Human, Mouse, Cynomolgus | Fc & Avi, Avi & His, His, Fc, Avi & His | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, ELISA, Cell based assay |
B7-H4 | Human, Mouse | His, Fc | Biotin-labeled, Unconjugated | SDS-PAGE, ELISA |
B7-H5 | Human, Mouse, Rhesus macaque | Fc & Avi, Avi & His, His, Fc, mFc | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, ELISA, SPR, BLI |
BTLA | Human, Mouse | Fc & Avi, His & Avi, His, mFc, Fc | Biotin-labeled, Unconjugated | SDS-PAGE, ELISA |
CD80(B7-1) | Human, Mouse, Cynomolgus / Rhesus macaque | Fc, Fc & Avi, Avi & His, mFc, His | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, HPLC, ELISA, SPR, BLI, |
CD86(B7-2) | Human, Mouse, Cynomolgus / Rhesus macaque | Fc & Avi, Fc, His | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, HPLC, ELISA, BLI, |
CD96 | Human | His & Avi, His, mFc | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, ELISA, BLI, |
CD47 | Human, Mouse, Rabbit, Rat, Cynomolgus / Rhesus macaque, Canine | Fc, His, Fc & Avi, His & Avi, mFc, mFc & Avi, LlamaFc | Biotin-labeled, FITC-labeled, Unconjugated | SDS-PAGE, MALS, ELISA, SPR, BLI, |
CD155 | Human, Mouse, Rhesus macaque | Fc & Avi, His & Avi, mFc, Fc, His | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, ELISA, BLI, |
CTLA-4 | Human, Mouse, Rabbit, Rat, Cynomolgus / Rhesus macaque | Fc, His, Fc & Avi, His & Avi, mFc, mFc& Avi | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, ELISA, SPR, BLI, |
LAG-3 | Human, Mouse, Rat, Cynomolgus, Marmoset | Fc, His, Fc & Avi, His & Avi, mFc, mFc & Avi, LlamaFc | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, ELISA, SPR, BLI, |
TIGIT | Human, Mouse, Rabbit, Rat, Cynomolgus / Rhesus macaque, Canine | mFc& Avi, Fc & Avi, His & Avi, His, Fc, mFc | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, HPLC, ELISA, SPR, BLI |
TIM-3 | Human, Mouse, Cynomolgus | Avi & His, mFc, Fc, His | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, ELISA, SPR |
CD111 | Human | His, Fc | Unconjugated | SDS-PAGE, ELISA, BLI |
DNAM-1 | Human, Cynomolgus | Fc & Avi, His, Fc | Biotin-labeled, Unconjugated | SDS-PAGE, ELISA, BLI, |
Galectin-9 | Human | His, MBP & His | Unconjugated | SDS-PAGE |
HVEM | Human | His, Twin-Strep, Fc, mFc, Fc & Avi | Biotin-labeled, Unconjugated , | SDS-PAGE, ELISA, BLI |
Nectin-2 | Human | His, Fc | Biotin-labeled, Unconjugated | SDS-PAGE, HPLC, ELISA, BLI |
Nectin-3 | Human | His, Fc | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, ELISA, BLI |
PVRIG | Human, Mouse, Cynomolgus | Fc & Avi, mFc& Avi, His & Avi, His, mFc | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, ELISA, BLI |
SIRP alpha | Human, Mouse, Cynomolgus | Fc, His & Avi, mFc& Avi, mFc, His | Biotin-labeled, PE-labeled, Unconjugated | SDS-PAGE, MALS, HPLC, ELISA, BLI, |
SIRP alpha V2 | Human | His | Biotin-labeled, Unconjugated | SDS-PAGE, ELISA |
SIRP gamma | Human | Fc | Unconjugated | SDS-PAGE, ELISA |
CD160 | Human | His | Unconjugated | SDS-PAGE, ELISA |
Moleküle | Spezies | Tags | Konjugate | Merkmale (Verfügbare Protokolle) |
---|---|---|---|---|
4-1BB Ligand | Human, Mouse, Rat, Cynomolgus | Fc, Fc & Avi, mFc, His & Flag | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, ELISA, BLI, Cell based assay |
4-1BB | Human, Mouse, Rat, Rabbit, Cynomolgus / Rhesus macaque, Canine | His, Fc, Fc & Avi, His & Avi, mFc | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, ELISA, SPR |
OX40 Ligand | Human, Mouse, Rhesus macaque | Fc, His, His & Avi, Avi & Fc, mFc | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, ELISA, BLI, |
OX40 | Human, Mouse, Rabbit, Rat, Rhesus macaque, Marmoset | His, Fc, His & Avi, Fc & Avi, Avi & His, mFc | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, ELISA, BLI, |
ICOS Ligand (B7-H2) |
Human, Mouse, Cynomolgus | His, Fc | Unconjugated | SDS-PAGE, ELISA |
ICOS | Human, Mouse, Cynomolgus | His, Fc, His & Avi | Biotin-labeled, Unconjugated | SDS-PAGE, ELISA |
GITR Ligand | Human, Mouse | His, Fc, Avi & Fc | Biotin-labeled, Unconjugated | SDS-PAGE, ELISA |
GITR | Human, Mouse, Rat, Rhesus macaque, Canine | His, Fc, His & Avi, Fc & Avi, mFc | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, ELISA |
CD48 | Human | His, Fc, mFc | Unconjugated | SDS-PAGE, ELISA |
HVEM | Human | His, Fc, Fc & Avi, mFc, TwiStrep | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, BLI |
Nectin-2 | Human | His, Fc, Fc & Avi, mFc | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, HPLC, ELISA, BLI |
CD40 Ligand | Human, Mouse, Human / Rhesus macaque | His, Fc, His & Avi, Avi & Fc, Avi & His & Flag, His & Flag, mFc | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, ELISA, BLI |
CD40 | Human, Mouse, Rabbit, Cynomolgus, Rhesus macaque | His, Fc, Avi & His, Fc & Avi, mFc | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, ELISA, BLI, |
CD30 ligand | Human | His, mFc | Unconjugated | SDS-PAGE, ELISA, BLI, |
CD30 | Human | His, Fc, Avi & His, LlamaFc | Biotin-labeled, PE-labeled, FITC-labeled, Unconjugated | SDS-PAGE, MALS, ELISA, BLI, |
CD28 | Mouse, Human / Cynomolgus / Rhesus macaque | His, Fc, His & Avi, Fc & Avi, mFc | Biotin-labeled, Unconjugated | SDS-PAGE, HPLC, ELISA, SPR, BLI |
CD27 Ligand | Human, Mouse | His & Avi, mFc, His, His & Avi & Flag, His & Flag, Fc | Biotin-labeled, FITC-labeled, Unconjugated | SDS-PAGE, MALS, HPLC, ELISA |
CD27 | Human, Mouse | His, Fc, Fc & Avi, mFc | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, HPLC, ELISA |
B7-1 | Human, Mouse, Cynomolgus / Rhesus macaque | Fc, Fc & Avi, Avi & His, mFc, His | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, HPLC, ELISA, SPR, BLI, |
B7-2 | Human, Mouse, Cynomolgus / Rhesus macaque | His, Fc, Fc & Avi | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, HPLC, ELISA, BLI, |
LIGHT | Human | His, mFc, Fc | Unconjugated | SDS-PAGE, MALS, ELISA, BLI |
B7-H7 | Human, Cynomolgus | His, Fc, His & Avi, Fc & Avi | Biotin-labeled, Unconjugated | SDS-PAGE, MALS, BLI |
B7-H6 | Human, Cynomolgus | His, His & Avi, Fc & Avi | Biotin-labeled, Unconjugated | SDS-PAGE, ELISA, SPR |
2B4 | Human | His, Fc, Avi & His | Biotin-labeled, Unconjugated | SDS-PAGE, ELISA |
CD28H | Human | His, Fc | Unconjugated | SDS-PAGE, ELISA |
NKp30 | Human | His, Fc | Unconjugated | SDS-PAGE, SPR |
LILRA&B | LILRA1 | LILRA2 | LILRA3 | LILRA5 | LILRA6 |
LILRB1 | LILRB2 | LILRB3 | LILRB4 | LILRB5 | |
LILRA&2 | LAIR-1 | LAIR-2 | |||
SLAMF | SLAMF1 | SLAMF2(CD48) | SLAMF3(CD229) | SLAMF4(2B4) | SLAMF5(CD84) |
SLAMF6(NTB-A) | SLAMF7 | SLAMF8(BLAME) | |
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Butyrophilins | BTN1A1 | BTN3A1 | BTN3A2 | BTN3A3 | |
Others | CD161 | MARCO | MSP1D1 | Nectin-1 | Nectin-4 |
ILDR2 | TREM2 | |
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Kat. Nr. | Produkt Beschreibung | Detection mechanism | Order/Preorder |
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The protocols are available for free.
Figure 1. The purity of Human CD27 Ligand, His,Flag Tag (active trimer) (MALS verified) (Cat. No. CDL-H52Da) is more than 95% in HP-SEC, and around 55-70 kDa verified by SEC-MALS.
The consistency in purity and bioactivity is essential for recombinant proteins.All our proteins have to pass a variety of purity and bioactivity assessments.
Biotinylated Human PD-1 / PDCD1 Protein, Avitag™,His Tag (recommended for biopanning) (MALS verified)(Cat. No. PD1-H82E4)
PD-1&PD-L1 pathway
Immobilized Human PD-1, His Tag (Cat. No. PD1-H5221) at 2 μg/mL (100 μL/well) can bind anti-PD-1 mab with a linear range of 0.1-3 ng/mL (Routinely tested).
PD-1&PD-L1 pathway
Serial dilutions of anti-PD-1 mab were added into Human PD-1, Fc Tag, low endotoxin (Cat. No. PD1-H5257): Biotinylated Human PD-L1, Fc, Avitag, His Tag (Cat. No. PD1-H82F3) binding reactions. The half maximal inhibitory concentration (IC50) is 0.5381 μg/mL (Routinely tested).
In addition, ACROBiosystems have also developed PD1: PD-L1 (Cat. No. EP-101) and CD47: SIRP alpha (Cat. No. EP-102) inhibitor screening assay kits that can screen neutralizing antibodies or small molecules with high throughput.
LAG-3 pathway
Loaded Anti-LAG-3 MAb (Human IgG1) on AHC Biosensor, can bind Human LAG-3, His Tag (Cat. No. LA3-H5222) with an affinity constant of 7.47 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
LAG-3 pathway
Anti-LAG-3 MAb (Human IgG1) captured on CM5 chip via Anti-Human IgG Fc antibodies surface, can bind Human LAG-3, His Tag (Cat. No. LA3-H5222) with an affinity constant of 4.57 nM as determined in a SPR assay (Biacore T200) (Routinely tested).
TIGIT pathway
Serial dilutions of Human TIGIT Neutralizing antibody were added into Human TIGIT, Fc Tag (Cat. No. TIT-H5254): Biotinylated Human CD155, Fc,Avitag (Cat. No. CD5-H82F6) binding reactions. The half maximal inhibitory concentration (IC50) is 0.55834 μg/mL (Routinely tested).
CD47&SIPR α pathway(Cell-based assay)
FACS analysis shows that the binding of Human CD47 to ACHN expressing SIRP-a was inhibited by increasing concentration of neutralizing SIRP-a antibody. The concentration of Human CD47 used is 20 μg/mL. IC50=9.334 μg/mL
4-1BB pathway
Human 4-1BB Ligand (71-254) Protein, Fc Tag, premium grade (Cat. No. 41L-H5269) induce IL‐8 secretion in HT1080 human CD137 cell line. The specific activity of Human 4-1BB Ligand (71-254) Protein, Fc Tag, premium grade is>1.00*10^5 U/mg (QC tested).
CTLA-4 pathway
Immobilized Human CTLA-4, His Tag, active dimer (Cat. No. CT4-H52H9) at 2 μg/mL, add increasing concentrations of CTLA-4 x OX40 Bispecific Antibody in 50% Human serum and then add Biotinylated Human OX40, Avitag, His Tag(Cat. No. TN4-H82E4) at 1 μg/mL. Detection was performed using HRP-conjugated streptavidin with sensitivity of 4 ng/mL (Intact assay, Routinely tested).
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