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Entdecken Sie unsere Reihe hochwertiger Proteine, die umfassende diagnostische Indikatoren zur Erleichterung der in-vitro-diagnostischen Erforschung neurologischer Erkrankungen abdecken.
Vorgeformte Fibrillen sind ein unschätzbares vorklinisches Modell für die Erforschung der Pathogenese neurologischer Erkrankungen aufgrund der Aggregation fehlgefalteter Proteine. Entdecken Sie unsere vorselektierten PFFs für Ihre Forschung.
Neuronaler Faktoren sind eine Klasse von Proteinmolekülen mit neurotropher Aktivität, die das Überleben und die Regeneration von Nervenzellen fördern können. Entdecken Sie unsere Reihe rekombinanter neuronaler Faktoren zur Unterstützung der Kultur und Differenzierung von Nervenzellen.
Neural antibodies can specifically label and recognize molecules on nerve cells, enabling a more comprehensive understanding and study of the biological properties, functions, and mechanisms of nerve cells in neurodegenerative diseases.
Covering iPSC neural cells, brain organoids, and microelectrode array services, our tools support neural development, disease modeling, and drug screening with high quality and reliable performance to meet diverse research needs.
Proteinmarker sind ein wesentlicher Bestandteil der biologischen Forschung und Arzneimittelentwicklung. Sei es für die Proteinelektrophorese oder den Western Blot, unsere vorgefärbten Proteinmarker helfen Ihnen, das Molekulargewicht des Zielproteins schnell zu bestimmen oder die Transfereffizienz zu bewerten.
Streptavidin ist ein tetrameres Protein mit 4 hochaffinen Biotin-Bindungsstellen. Wir bieten eine breite Palette von Produkten an, die mit Streptavidin vorkonjugiert sind, ebenso wie biotinylierte Proteine, um Ihre Forschung zu unterstütze.
Die Einstellung des entsprechenden Isotyp-Kontrollantikörpers zum Nachweis unspezifischer Bindungen kann die Entstehung falsch positiver Ergebnisse verringern und die möglichen Einflussfaktoren im Prozess der Arzneimittelentwicklung genau bewerten. Entdecken Sie unsere Isotyp-Kontrollen für Ihre Forschung.
Möchten Sie Ihren eigenen Chemilumineszenztest entwickeln? Entdecken Sie unsere Produkte, um Ihren eigenen MPCLIA für Ihre Bedürfnisse zusammenzustellen!
Die Wirksamkeit eines therapeutischen Antikörpers hängt vom Fab-Fragment und seiner Bindungsaktivität an das Zielantigen ab, aber auch vom Fc-Fragment und seiner Interaktion mit den wichtigsten Fc-Rezeptoren, weshalb die Kandidaten während des Antikörper-Engineerings an einer Reihe von Rezeptoren getestet werden müssen. Entdecken Sie unsere umfassende Sammlung rekombinanter Fc-Rezeptor-Proteine!
Wir haben uns verpflichtet, die Forschung, Entwicklung, Zulassung und Vermarktung von Impfstoffen gegen Infektionskrankheiten zu beschleunigen. Mit dieser Idee ist ViruStop speziell für die Virenforschung entwickelt worden!
Antigen-spezifische oder neutralisierende Antikörper sind für Ihre Forschung verfügbar! Egal, ob Sie neutralisierende Assays durchführen oder Antikörpertiter bewerten möchten, - entdecken Sie unseren Antikörperkatalog!
Colony-stimulating factors (CSFs) are of low molecular cytokines that stimulate the proliferation, differentiation, and colony formation of bone marrow hematopoietic stem cells. CSFs bind to receptor proteins on the surface of hematopoietic stem cells to activate downstream signals that promote the production of specific types of hematopoietic cells (usually leukocytes) in response to infection. Studies have shown that CSFs are also up-regulated in a variety of malignancies through both immune-dependent and non-immune-dependent pathways to promote tumor cell growth, invasion, and migration.
Schematic diagram of CSFs and their receptor families
Different Types of CSF Targets
Macrophage colony-stimulating factor 1 (M-CSF) binds with its receptor (M-CSF R) to promote monocyte survival, promotes monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. It also initiates and enhances macrophage killing of tumor cells and microorganisms, modulates macrophage release of cytokines and other inflammatory modulators.
Granulocyte-macrophage colony stimulating factor 2 (GM-CSF), through binding to its receptor GM-CSF R, promotes cell proliferation, survival, differentiation and other biological effects. Aberrant expression of GM-CSF leads to excessive inflammation, pain, chemotaxis and tissue damage, which promotes the production of other pathogenic and inflammatory cytokines.
Granulocyte colony-stimulating factor (G-CSF) mainly acts on the proliferation, differentiation and activation of hematopoietic cells of the neutrophil lineage. In vitro, it stimulates neutrophil precursors of bone marrow hematopoietic cells to differentiate and proliferate to form mature granulocyte colonies. This improves phagocytosis of neutrophils and promotes superoxide production.
To support drug discovery targeting CSFs/CSF Rs, ACROBiosystems has developed a series of high-quality cytokines for immunization, antibody drug screening and characterization; helping you accelerate your antibody drug development process.
Product Features
HEK293 expressed, close to natural conformation
High biological activity verified by SPR/ BLI/ Cell Assays
Strict quality control to guarantee high batch-to-batch consistency
ELISA as QC test to guarantee high quality, free protocol shared
Supporting your Cell Culture
To support ongoing cell therapy manufacture and development, ACROBiosystems has developed a wide array of high-quality cytokines to culture immune cells, stem cells, organoids, and various other types of cells.
Our premium-grade growth factors, including CSFs, have:
Low Endotoxin (≤ 0.1 EU/µg) Sterile, Animal-origin Free Validated Bioactivity and Lot-to-Lot Consistency Seamlessly transition to GMP-grade
Immobilized Human M-CSF R, Fc Tag (Cat. No. CSR-H5258) at 2 μg/mL (100 μL/well) can bind Biotinylated Human M-CSF, His,Avitag (Cat. No. MCF-H82E6) with a linear range of 0.1-2 ng/mL (QC tested).
Immobilized Human GM-CSF, premium grade (Cat. No. GMF-H4214) at 1 μg/mL (100 μL/well) can bind Human GM-CSF R alpha, Fc Tag (Cat. No. GRA-H5255) with a linear range of 0.5-16 ng/mL (QC tested).
Immobilized Human G-CSF, premium grade (Cat. No. GCF-H5214) at 2 μg/mL (100 μL/well) can bind Biotinylated Human G-CSF R, Avitag,His Tag (Cat. No. GCR-H82E4) with a linear range of 0.156-1.25 μg/mL (QC tested).
Affinity (SPR)
Biotinylated Human M-CSF, His,Avitag (Cat. No. MCF-H82E6) immobilized on SA Chip can bind Human M-CSF R, His Tag (Cat. No. CSR-H5228) with an affinity constant of 0.309 μM as determined in a SPR assay (Biacore T200) (Routinely tested).
Human GM-CSF R alpha, His Tag (Cat. No. GRA-H52H7) captured on CM5 Chip via anti-His antibody, can bind Human GM-CSF, premium grade (Cat. No. GMF-H4214) with an affinity constant of 16.1 nM as determined in SPR assay (Biacore T200) (QC tested).
Affinity (BLI)
Loaded Human M-CSF, His Tag (Cat. No. MCF-H5247) on HIS1K Biosensor, can bind Human M-CSF R, Fc Tag, low endotoxin (Cat. No. CSR-H5258) with an affinity constant of 3.29 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
Loaded Biotinylated Human GM-CSF, epitope tag free, primary amine labeling (Cat. No. GMF-H8214) on SA Biosensor, can bind Human GM-CSF R alpha, His Tag (Cat. No. GRA-H52H7) with an affinity constant of 23.1 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
High biological activity (Cell Base)
Human M-CSF, His Tag (Cat. No. MCF-H5247) stimulates proliferation of RAW264.7 cells. The EC50 for this effect is 4.40-5.27 ng/mL (Routinely tested).
Human GM-CSF, premium grade(Cat. No. GMF-H4214) stimulates proliferation of GM-CSF-activated TF-1 cell. The specific activity of Human GM-CSF, premium grade is > 1.0ⅹ10^7 IU/mg , which is calibrated against human GM-CSF WHO International Standard (NIBSC code: 88/646) (QC tested).
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HEK293 expressed, close to natural conformation
