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A-Z
> CAR-Targets für solide Tumore
Nature reviews. Drug discovery vol. 20,7 (2021): 531-550.
Mehr als 30 + solide Tumorziele
Verschiedene Arten, darunter Mensch, Maus, Affe, Kaninchen usw.
Hohe Bioaktivität, bestätigt durch FACS/ELISA/SPR
Alexa Fluor 488/555/647, PE, APC, FITC-Marken verfügbar
Einige Produkte sind beim DMF der FDA eingereicht worden, um Ihre IND, NDA und BLA zu unterstützen
> Mesothelin, MSLN
> Starke Expression in Mesotheltumoren, Eierstockkrebs und Bauchspeicheldrüsenkrebs
> Abnormale Expression von Mesothelin durch Aktivierung von P13K-, ERK- und MAPK-Signalwegen führt zu Proliferation, Invasion und Metastasierung von Krebszellen.
> Glypican 3, GPC3
> Assoziiert mit hepatozellulärem Karzinom, Ovarialkarzinom und Plattenepithelkarzinom
> Interagiert mit verschiedenen Wachstumsfaktoren und Signalmolekülen in der Tumormikroumgebung, die die Proliferation, Migration, Invasion und den Entwicklungsprozess von Tumorzellen beeinflussen.
> Humaner epidermaler Wachstumsfaktor-Rezeptor 2, HER2
> Steht in Zusammenhang mit Brustkrebs, Magenkrebs, Lungenkrebs und nicht-kleinzelligem Lungenkrebs
> Fördert die Zellteilung und die Sekretion proteolytischer Enzyme und damit die Invasion und Metastasierung von Tumoren.
> Fibroblasten-Aktivierungsprotein, FAP
> Selektiv hohe Expression auf der Oberfläche von krebsassoziierten Fibroblasten (CAF)
> Degradiert das Tumorstroma und fördert die Invasion und Metastasierung von Krebszellen in einer Vielzahl von Tumoren.
The purity of Human Mesothelin (296-580), His Tag, low endotoxin (Cat. No. MSN-H522a) is more than 90% and the molecular weight of this protein is around 32-47 kDa verified by SEC-MALS.
Immobilized Monoclonal Anti-Human GPC3 Antibody, Human IgG1 at 2 μg/mL (100 μL/well) can bind Biotinylated Human Glypican 3, His, Avitag (Cat. No. GP3-H82E5) with a linear range of 0.2-3 ng/mL (QC tested).
Immobilized Human Her2, His Tag (Cat. No. HE2-H5225) at 0.05 μg/mL (100 μL/well) can bind Trastuzumab with a linear range of 0.2-3 ng/mL (Routinely tested).
5e5 of anti-MSLN CAR-293 cells were stained with 100 μL of 3 μg/mL of AF488-Labeled Human Mesothelin (296-580), His Tag (Cat. No. MSN-HA2H9) and negative control protein respectively (Fig. C and B), and non-transfected 293 cells were used as a control (Fig. A). AF488 signal was used to evaluate the binding activity (QC tested).
5e5 of anti-Her2 CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of APC-Labeled Human Her2, His Tag (Cat. No. HE2-HA2H7) and negative control protein respectively. APC signal was used to evaluate the binding activity (QC tested).
5e5 of anti-GPC3 CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human Glypican 3, His Tag (Cat. No. GP3-HP2E3) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).
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