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Your Position: Start > Protein > FGF-6 > FG6-H51H4

Human FGF-6 Protein, His Tag

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  • Synonym
    FGF-6,Fibroblast growth factor 6,HST-2,HBGF-6
  • Source
    Human FGF-6 Protein, His Tag(FG6-H51H4) is expressed from E. coli cells. It contains AA Gly 41 - Ile 208 (Accession # P10767-1).
    Predicted N-terminus: Gly 41
  • Molecular Characterization
    FGF-6 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 20.6 kDa. The protein migrates as 23-25 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 20 mM Sodium Citrate, pH3.0 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
FGF-6 SDS-PAGE

Human FGF-6 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

Bioactivity-ELISA
 FGF-6 ELISA

Immobilized Human FGF-6 Protein, His Tag (Cat. No. FG6-H51H4) at 5 μg/mL (100 μL/well) can bind Human FGF R4, Fc Tag (Cat. No. FG4-H5253) with a linear range of 0.039-1.25 μg/mL (QC tested).

Bioactivity-SPR
 FGF-6 SPR

Human FGF-6 Protein, His Tag (Cat. No. FG6-H51H4) immobilized on CM5 Chip can bind Human FGF R1, His Tag (Cat. No. FG1-H5223) with an affinity constant of 45 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

 FGF-6 SPR

Human FGF-6 Protein, His Tag (Cat. No. FG6-H51H4) immobilized on CM5 Chip can bind Human FGF R4, Fc Tag (Cat. No. FG4-H5253) with an affinity constant of 13.4 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

 FGF-6 SPR

Human FGF-6 Protein, His Tag (Cat. No. FG6-H51H4) immobilized on CM5 Chip can bind Human FGF R2 (IIIb), Fc Tag (Cat. No. FGB-H5256) with an affinity constant of 33.2 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

  • Background
    Fibroblast growth factor 6 plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.
    For instance, FGF-6 might involve in MSCs proliferation and chondrogenic differentiation. Additionally, FGF-6 were identified as oncogene products. FGF6 is found over expressed in prostatic intraepithelial neoplasia and prostate cancer and promotes the proliferation of the transformed prostatic epithelial cells.
  • Clinical and Translational Updates

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