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Neuroscience Frontier Tools Selection

Neuroscience Frontier Tools Selection
Introduction

With the rapid advancements in neuroscience, researchers are uncovering the complexities of the nervous system, particularly in studies on neurodevelopmental disorders, neurodegenerative diseases (e.g., Parkinson's disease, Alzheimer's disease), and brain injury repair mechanisms. However, due to the complexity of the nervous system, traditional 2D cell and animal models fall in fully simulating the human brain's microenvironment and dynamic changes. As a result, scientists are turning to more advanced tools and models to explore neural functions and pathological mechanisms.

To support this, we offer a range of cutting-edge neuroscience tools, including iPSC-Derived neural cells, brain organoids, and microelectrode array (MEA) services. These products and services provide advanced platforms for research in neurodevelopment, neurodegenerative diseases, drug screening, and neural network activity analysis, enabling researchers to delve deeper into the neuroscience.

iPSC-Derived Neural Cells

Our products include iPSC-Derived neural progenitor cells and iPSC-Derived dopamine neurons. Neural progenitor cells possess multipotent differentiation capacity, efficiently generating various types of neurons and support cells, while dopamine neurons accurately model the function of human substantia nigra dopamine neurons. These cell products offer high efficiency and consistency, ideal for drug screening, toxicology studies, and disease modeling.

High-quality sources: Derived from healthy controls and Parkinson’s disease patients, ensuring reliable results.
Rigorous characterization: Validated through immunofluorescence and electrophysiology for functional reliability.
Optimized cryopreservation: Frozen at the optimal differentiation stage to ensure high viability and functionality.

Neural Progenitor Cells Differentiate Into Dopamine Neurons

Human iPSC-Derived Neural Progenitor Cells (Cat. No. CIPC-NWC001) have the ability to differentiate into dopaminergic neurons (Cat. No. CIPC-DWC001), characterized by immunocytochemistry using well-known markers such as TH and MAP2.

Cat. No.Product DescriptionDonor Status
CIPC-NWC001Human iPSC-Derived Neural Progenitor CellsHealthy
CIPC-NDC001Human iPSC-Derived Neural Progenitor Cells (Parkinson's disease)Parkinson's disease
CIPC-DWC001Human iPSC-Derived Dopamine NeuronsHealthy
CIPC-DDC001Human iPSC-Derived Dopamine Neurons (Parkinson's disease)Parkinson's disease
Brain Organoids

iPSC-Derived brain organoids possess similar structure and electrophysiological properties to human brain, making them valuable tools for neuropharmacological screening, disease modeling, AAV vector screening, and neurodevelopmental research. We offer cerebral organoid and midbrain organoid products to provide researchers with robust experimental models.

Ready-to-use/cryopreserved brain organoids, and differentiation/maintenance/cryopreservation kits are available.
Strict quality control: Ensures high quality and batch-to-batch consistency.
Human brain-like cell types: Various neurons and glial cells, resembling human brain tissue.
Functional characteristics: Spontaneous electrophysiological activity, suitable for Alzheimer’s and Parkinson’s disease modeling and drug screening.

Marker Expression of Midbrain Organoids

The midbrain organoids (Cat. No. CIPO-MBWL001K) exhibit high expression of TH (dopaminergic neurons), MAP2 (mature neurons), as well as FOXA2 and OTX2 (dopaminergic progenitor cells) on day 37.

Cat. No.Product Description
CIPO-BWL001KReady-to-use Human iPSC-Derived Cerebral Organoids
CIPO-MBWL001KReady-to-use Human iPSC-Derived Midbrain Organoids
CIPO-BWL001KCCryopreserved Human iPSC-Derived Cerebral Organoids
RIPO-BWM001KHuman iPSC-Derived Cerebral Organoid Differentiation Kit
RIPO-BWM003Human iPSC-Derived Cerebral Organoid Maturation and Maintenance Kit
RIPO-BWM006Cerebral Organoid Cryopreservation Kit
Microelectrode Array Services

Microelectrode Array (MEA) is an advanced electrophysiological technology that allows real-time, non-invasive recording of cellular electrical signals, enabling long-term monitoring of neuronal network activity and capturing complex signal patterns. This technology is suitable for high-throughput drug screening, neurotoxicity assessment, and drug efficacy testing, providing reliable data for drug development. We offer industry-leading MEA detection services for electrophysiological activity in both 2D cells and organoids.

Precise, non-invasive data collection: Records extracellular voltage of electrically active cells without labels or invasive procedures, preserving their natural state.
Optimized experimental environment: Stable CO2 and temperature control for short- or long-term studies.
Industry-leading organoid electrophysiology: Successfully applied MEA systems to cardiac and cerebral organoids, effectively testing ECG in heart models and the generation and transmission of neural electrical signals in brain models.

MEA Verified Spontaneous Network Burst Activity

Spontaneous firing activity of Human iPSC-Derived Dopamine Neurons (Cat. No. CIPC-DDC001) on MEA plates. The heatmap video and raster plot illustrate regular network burst patterns, confirming successful neuron culture and strong functional connectivity, indicating the product's suitability for neurophysiological research.

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