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Your Position: Start > Antibody > VP4 (Rotavirus A) > VP4-M762

Monoclonal Anti-Rotavirus A VP4 Antibody, Human IgG1 (4D2)

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  • Source

    Monoclonal Anti-Rotavirus A VP4 Antibody, Human IgG1 (4D2) is a chimeric monoclonal antibody recombinantly expressed from HEK293, which combines the variable region of a mouse monoclonal antibody with Human constant domain.

  • Clone

    4D2

  • Isotype

    Human IgG1 | Human Kappa

  • Conjugate

    Unconjugated

  • Antibody Type

    Recombinant Monoclonal

  • Reactivity

    Virus

  • Immunogen

    Recombinant Rotavirus A (strain RVA/Human/United States/Wa/1974/G1P1A[8]) VP4 Protein is expressed from human 293 cells.

  • Specificity

    Specifically recognizes Rotavirus A VP4.

  • Application
    ApplicationRecommended Usage
    ELISA0.1-63 ng/mL
  • Purity

    >95% as determined by SDS-PAGE.

  • Purification

    Protein A purified/ Protein G purified

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
VP4 (Rotavirus A) SDS-PAGE

Monoclonal Anti-Rotavirus A VP4 Antibody, Human IgG1 (4D2) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

Bioactivity-ELISA
 VP4 (Rotavirus A) ELISA

Immobilized Rotavirus A VP4 Protein, His Tag (Cat. No. VP4-R5243) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Rotavirus A VP4 Antibody, Human IgG1 (4D2) (Cat. No. VP4-M762) with a linear range of 0.1-2 ng/mL (QC tested).

Bioactivity-SPR
 VP4 (Rotavirus A) SPR

Monoclonal Anti-Rotavirus A VP4 Antibody, Human IgG1 (4D2) (Cat. No. VP4-M762) captured on Protein A Chip can bind Rotavirus A VP4 Protein, His Tag (Cat. No. VP4-R5243) with an affinity constant of 1.07 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

  • Background
    Rotavirus is the leading cause of severe, watery diarrhea in infants and children less than 5 years old. It is estimated that around three-quarters of infants and children had rotavirus diarrhea before the age of 12 months and over millions of them were hospitalized due to the rotavirus infection. The rotavirus has various structural viral protein (VPs) and non-structural protein (NSPs), among them, the VP4 and VP7 together determines the serotypes of the virus, with the VP4 determines the P-type and VP-7 determines the G-type. The reassortment of these proteins leads to the diversity of the rotavirus strains, making the VP4 and VP7 the important target for vaccine studies.
  • Clinical and Translational Updates

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