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| Project Name | Project Stage | Molecule Type | Host Species | Therapeutic Area | Indications |
| ROR1 mAb - 01 | Lead | Hematological Malignancy,AutoImmunity | Solid tumor,Blood tumor |
Expression analysis of human ROR1 on HEK293/Human ROR1 Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human ROR1 Stable Cell Line or negative control cell using PE-labeled anti-human ROR1 antibody.
5e5 of anti-ROR1 CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human ROR1 Protein, His Tag (Cat. No. RO1-HP2E3) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).
Anti-Human ROR1 mAb captured on CM5 chip via anti-mouse antibodies surface can bind Biotinylated Human / Cynomolgus / Rhesus macaque ROR1, His, Avitag (Cat. No. RO1-H82E6) with an affinity constant of 5.81 nM as determined in a SPR assay (Biacore T200) (Routinely tested).
| Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
|---|---|---|---|---|---|
| Zilovertamab vedotin | VLS-101; MK-2140 | Phase 3 Clinical | Oncternal Therapeutics Inc, University Of California San Diego | Breast Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Carcinoma, Non-Small-Cell Lung; Waldenstrom Macroglobulinemia; Burkitt Lymphoma; Lymphoma, T-Cell; Leukemia, Myeloid, Acute; Richter's Syndrome; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, B-Cell; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Neoplasms; Lymphoma, Large B-Cell, Diffuse; Pancreatic Neoplasms; Stomach Neoplasms; Lymphoma, B-Cell, Marginal Zone; Ovarian Neoplasms; Hematologic Neoplasms | Details |
| Zilovertamab | UC-961 | Phase 2 Clinical | University Of California San Diego, Oncternal Therapeutics Inc | Lymphoma, B-Cell, Marginal Zone; Lymphoma, B-Cell; Immunoproliferative Disorders; Lymphatic Diseases; Immune System Diseases; Prostatic Neoplasms, Castration-Resistant; Lymphoma, Mantle-Cell; Breast Neoplasms; Lymphoproliferative Disorders; Lymphoma; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell | Details |
| ONCT-808 | ONCT-808 | Phase 2 Clinical | Oncternal Therapeutics Inc | Lymphoma, B-Cell; Neoplasms | Details |
| Nebratamig | GNC-035 | Phase 2 Clinical | Solid tumours; Hematologic Neoplasms; Breast Neoplasms; Metastatic breast cancer; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell | Details | |
| HG-030 | HG-030 | Phase 1 Clinical | Hitgen Inc | Solid tumours | Details |
| EMB-07 | EMB-07 | Phase 1 Clinical | Shanghai Epimab Biotherapeutics, Inc | Solid tumours; Ovarian Neoplasms; Stomach Neoplasms; Neoplasms; Triple Negative Breast Neoplasms; Adenocarcinoma of Lung; Pancreatic Neoplasms; Urinary Bladder Neoplasms; Prostatic Neoplasms; Colorectal Neoplasms; Lymphoma; Uterine Neoplasms; Neoplasm Metastasis | Details |
| PB-004 | PB004; PBA-0405; PB004 PureBIKE; PB-004 | Phase 1 Clinical | Pure Biologics SA | Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Sarcoma | Details |
| PRGN-3007 | PRGN-3007 | Phase 1 Clinical | Precigen Inc | Hematologic Neoplasms; Solid tumours; Lymphoma, Large B-Cell, Diffuse; Triple Negative Breast Neoplasms; Lymphoma, Mantle-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Lymphocytic, Chronic, B-Cell | Details |
| LYL-797 | LYL-797 | Phase 1 Clinical | Lyell Immunopharma Inc | Solid tumours; Triple Negative Breast Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
| NVG-111 | NVG-111 | Phase 1 Clinical | NovalGen Ltd | Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Follicular; Melanoma; Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell | Details |
| LCB-71 | CS-5001; LCB-71; ABL-202 | Phase 1 Clinical | Legochem Biosciences Inc, Abl Bio Inc | Solid tumours; Lymphoma, B-Cell; Hematologic Neoplasms; Lymphoma | Details |
| SIM-201 | SIM-201; SIM-0201 | Phase 1 Clinical | Jiangsu Simcere Pharmaceutical Co Ltd | Solid tumours | Details |
| Zilovertamab vedotin | VLS-101; MK-2140 | Phase 3 Clinical | Oncternal Therapeutics Inc, University Of California San Diego | Breast Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Carcinoma, Non-Small-Cell Lung; Waldenstrom Macroglobulinemia; Burkitt Lymphoma; Lymphoma, T-Cell; Leukemia, Myeloid, Acute; Richter's Syndrome; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, B-Cell; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Neoplasms; Lymphoma, Large B-Cell, Diffuse; Pancreatic Neoplasms; Stomach Neoplasms; Lymphoma, B-Cell, Marginal Zone; Ovarian Neoplasms; Hematologic Neoplasms | Details |
| Zilovertamab | UC-961 | Phase 2 Clinical | University Of California San Diego, Oncternal Therapeutics Inc | Lymphoma, B-Cell, Marginal Zone; Lymphoma, B-Cell; Immunoproliferative Disorders; Lymphatic Diseases; Immune System Diseases; Prostatic Neoplasms, Castration-Resistant; Lymphoma, Mantle-Cell; Breast Neoplasms; Lymphoproliferative Disorders; Lymphoma; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell | Details |
| ONCT-808 | ONCT-808 | Phase 2 Clinical | Oncternal Therapeutics Inc | Lymphoma, B-Cell; Neoplasms | Details |
| Nebratamig | GNC-035 | Phase 2 Clinical | Solid tumours; Hematologic Neoplasms; Breast Neoplasms; Metastatic breast cancer; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell | Details | |
| HG-030 | HG-030 | Phase 1 Clinical | Hitgen Inc | Solid tumours | Details |
| EMB-07 | EMB-07 | Phase 1 Clinical | Shanghai Epimab Biotherapeutics, Inc | Solid tumours; Ovarian Neoplasms; Stomach Neoplasms; Neoplasms; Triple Negative Breast Neoplasms; Adenocarcinoma of Lung; Pancreatic Neoplasms; Urinary Bladder Neoplasms; Prostatic Neoplasms; Colorectal Neoplasms; Lymphoma; Uterine Neoplasms; Neoplasm Metastasis | Details |
| PB-004 | PB004; PBA-0405; PB004 PureBIKE; PB-004 | Phase 1 Clinical | Pure Biologics SA | Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Sarcoma | Details |
| PRGN-3007 | PRGN-3007 | Phase 1 Clinical | Precigen Inc | Hematologic Neoplasms; Solid tumours; Lymphoma, Large B-Cell, Diffuse; Triple Negative Breast Neoplasms; Lymphoma, Mantle-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Lymphocytic, Chronic, B-Cell | Details |
| LYL-797 | LYL-797 | Phase 1 Clinical | Lyell Immunopharma Inc | Solid tumours; Triple Negative Breast Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
| NVG-111 | NVG-111 | Phase 1 Clinical | NovalGen Ltd | Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Follicular; Melanoma; Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell | Details |
| LCB-71 | CS-5001; LCB-71; ABL-202 | Phase 1 Clinical | Legochem Biosciences Inc, Abl Bio Inc | Solid tumours; Lymphoma, B-Cell; Hematologic Neoplasms; Lymphoma | Details |
| SIM-201 | SIM-201; SIM-0201 | Phase 1 Clinical | Jiangsu Simcere Pharmaceutical Co Ltd | Solid tumours | Details |
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