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CCL14

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CC4-H5249 Human Human CCL14 / HCC-1 Protein, His Tag
CC4-H5249-structure
CC4-H5249-sds
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Synonym Name

C-C motif chemokine 14,Chemokine CC-1/CC-3,HCC-1/HCC-3,HCC-1(1-74),NCC-2,Small-inducible cytokine A14,CCL14,NCC2, SCYA14

Background

CCL14 has weak activity on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca2+ changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.

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