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Your Position: Start > CD133

CD133

Brief Information

Name:CD133
Target Synonym:Antigen AC133,Prominin-1,PROM1,Prominin 1,Prominin-Like Protein 1,PROML1,Stargardt Disease 4 (Autosomal Dominant),Hematopoietic Stem Cell Antigen,Macular Dystrophy, Retinal 2,Prominin (Mouse)-Like 1,CD133 Antigen,HProminin,MSTP061,CORD12,AC133,CD133,MCDR2,STGD4,RP41,AC133 Antigen
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Kat. Nr. Arten Produktbeschreibung Struktur Reinheit Merkmal
CD3-H82E5 Human Biotinylated Human CD133 Full Length Protein, His,Avitag™ (Detergent)
CD3-H82E5-structure
CD3-C82E3 Cynomolgus Biotinylated Cynomolgus CD133 Full Length Protein, His,Avitag™ (Detergent)
CD3-C82E3-structure
CD3-H52P3 Human Human CD133 Full Length Protein (VLP)
CD3-H52H1 Human Human CD133 Full Length Protein, His Tag (Nanodisc)
CD3-H52H1-structure
CD3-H52H1-sds
CD3-H52H4 Human Human CD133 Protein, His Tag (Detergent)
CD3-H52H4-structure
CD3-H52H4-sds
ACRO Quality

Part of Bioactivity data

CD3-H52H1-Cell-based assay
CD133 FACS

2e5 of Anti-CD133 CAR-293 cells were stained with 100 μL of 3 μg/mL of Human CD133 Full Length Protein, His Tag (Cat. No. CD3-H52H1) and negative control protein respectively, washed and then followed by PE-anti-His Tag antibody and analyzed with FACS (QC tested).

Protocol
CD3-C82E3-ELISA
CD133 ELISA

Immobilized Biotinylated Cynomolgus CD133 Full Length Protein, His,Avitag (Cat. No. CD3-C82E3) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Monoclonal Anti-Human CD133 Antibody, Human IgG1 with a linear range of 0.06-2 ng/mL (QC tested).

Protocol
CD3-H82E5-ELISA
CD133 ELISA

Immobilized Biotinylated Human CD133 Full Length Protein, His,Avitag™ (Cat. No. CD3-H82E5) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Monoclonal Anti-Human CD133 Antibody, Human IgG1 (Cat. No. CD3-M76) with a linear range of 0.2-16 ng/mL (QC tested).

Protocol

Synonym Name

CD133,PROM1,PROML1,Prominin-1,AC133

Background

Prominin-1 is also known as CD133, Antigen AC133, PROM1, PROML1 and MSTP061. Is used as marker for hematopoietic stem and progenitor cells (HSPC) for somatic stem cell isolation. May play a role in cell differentiation, proliferation and apoptosis . Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
anti-CD133-CAR vector-transduced T cells Phase 2 Clinical Pla General Hospital Liver Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Breast Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Brain Neoplasms; Colorectal Neoplasms Details
anti-CD133-CAR vector-transduced T cells Phase 2 Clinical Pla General Hospital Liver Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Breast Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Brain Neoplasms; Colorectal Neoplasms Details

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