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Your Position: Start > Trastuzumab

Trastuzumab

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TRB-Y1b Mouse Anti-Trastuzumab Antibody (AY1b) (recommended for PK/PD)
TRB-Y1b-sds
TRB-Y5b Mouse Anti-Trastuzumab Antibody (AY5b) (recommended for PK/PD)
TRB-Y5b-sds
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Part of Bioactivity data

TRB-Y1b-SPR
Trastuzumab SPR

Trastuzumab captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Anti-Trastuzumab Antibody (AY1b) (Cat. No. TRB-Y1b) with an affinity constant of 0.729 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
TRB-Y5b-SPR
Trastuzumab SPR

Trastuzumab captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Anti-Trastuzumab Antibody (AY5b) (Cat. No. TRB-Y5b) with an affinity constant of 0.915 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

Synonym Name

Background

Trastuzumab, is a monoclonal antibody used to treat breast cancer. Specifically it is used for breast cancer that is HER2 receptor positive. Trastuzumab works by binding to the HER2 receptor and slowing down cell duplication. Trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein.

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