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Your Position: Start > Siglec-10

Siglec-10

Brief Information

Name:Sialic acid-binding Ig-like lectin 10
Target Synonym:UNQ477/PRO940,SIGLEC10,Sialic Acid Binding Ig Like Lectin 10,Sialic Acid Binding Ig-Like Lectin 10 Ig-Like Lectin 7,Siglec-Like Protein 2,Siglec-Like Gene 2,SLG2,Sialic Acid-Binding Ig-Like Lectin 10,Sialic Acid Binding Ig-Like Lectin 10,Siglec-10,PRO940,MGC126774
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 3 Clinical

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Kat. Nr. Arten Produktbeschreibung Struktur Reinheit Merkmal
SI0-C82E5 Cynomolgus Biotinylated Cynomolgus Siglec-10 Protein, His,Avitag™ (MALS verified)
SI0-C82E5-structure
SI0-C82E5-sds
SI0-H5255 Human Human Siglec-10 Protein, Fc (L118A, G120A, E201A) Tag
SI0-H5255-structure
SI0-H5255-sds
SI0-H5254 Human Human Siglec-10 Protein, Fc (L117A, L118A) Tag
SI0-H5254-structure
SI0-H5254-sds
SI0-C52H5 Cynomolgus Cynomolgus Siglec-10 Protein, His Tag (MALS verified)
SI0-C52H5-structure
SI0-C52H5-sds
SI0-HP2E5 Human PE-Labeled Human Siglec-10 Protein, His Tag (recommended for neutralizing assay) (Site-specific conjugation)
SI0-HP2E5-structure
SI0-H82E3 Human Biotinylated Human Siglec-10 Protein, His,Avitag™
SI0-H82E3-structure
SI0-H82E3-sds
SI0-H82F6 Human Biotinylated Human Siglec-10 Protein, Fc,Avitag™ (MALS verified)
SI0-H82F6-structure
SI0-H82F6-sds
SI0-M52H7 Mouse Mouse Siglec-10 Protein, His Tag
SI0-M52H7-structure
SI0-M52H7-sds
SI0-H52H9 Human Human Siglec-10 Protein, His Tag (MALS verified)
SI0-H52H9-structure
SI0-H52H9-sds
SI0-H5253 Human Human Siglec-10 Protein, Fc Tag
SI0-H5253-structure
SI0-H5253-sds
SI0-H525b Human Human Siglec-10 Protein, Mouse IgG2a Fc Tag, low endotoxin
SI0-H525b-structure
SI0-H525b-sds
ACRO Quality

Part of Bioactivity data

SI0-HP2E5-Cell-based assay
Siglec-10 FACS

2e5 of 293 cells overexpressing human CD24 were stained with 100μL of 1:10 dilution of PE-Labeled Human Siglec-10 Protein, His Tag(recommended for neutralizing assay)(Cat. No. SI0-HP2E5)and negative control protein respectively , washed and analyzed with FACS (QC tested).

Protocol
SI0-H5255-BLI
Siglec-10 BLI

Loaded Human CD32a (R167), His Tag (Cat. No. CDA-H5221) on HIS1K Biosensor, can bind Human Siglec-10, Fc (L118A, G120A, E201A) Tag (Cat. No. SI0-H5255) with an affinity constant of 37.5 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
SI0-H5255-BLI
Siglec-10 BLI

Loaded Human CD64, His Tag (Cat. No. FCA-H52H1) on HIS1K Biosensor, can bind Human Siglec-10, Fc (L118A, G120A, E201A) Tag (Cat. No. SI0-H5255) with an affinity constant of 42.1 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Customer Reviews

Synonym Name

SIGLEC10,MGC126774,PRO940,Siglec10,SLG2

Background

The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Efprezimod alfa CD24-Fc; HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110 Phase 3 Clinical Oncoimmune Inc Solid tumours; Hematopoietic stem cell transplantation (HSCT); Leukemia; HIV Infections; Graft vs Host Disease; Myelodysplastic Syndromes; Coronavirus Disease 2019 (COVID-19); Precursor Cell Lymphoblastic Leukemia-Lymphoma; Dyslipidemias; Leukemia, Myeloid, Acute; Melanoma Details
EXO-CD24 Phase 2 Clinical Tel-Aviv Sourasky Medical Center, Nano24med Coronavirus Disease 2019 (COVID-19); Respiratory Distress Syndrome, Adult Details
AI-071 AI-071 Phase 1 Clinical Oncoimmune-Guangzhou Neoplasms; Coronavirus Disease 2019 (COVID-19) Details
ONC-841 ONC-841 Phase 1 Clinical Oncoimmune-Guangzhou Solid tumours; Neoplasms Details
Efprezimod alfa CD24-Fc; HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110 Phase 3 Clinical Oncoimmune Inc Solid tumours; Hematopoietic stem cell transplantation (HSCT); Leukemia; HIV Infections; Graft vs Host Disease; Myelodysplastic Syndromes; Coronavirus Disease 2019 (COVID-19); Precursor Cell Lymphoblastic Leukemia-Lymphoma; Dyslipidemias; Leukemia, Myeloid, Acute; Melanoma Details
EXO-CD24 Phase 2 Clinical Tel-Aviv Sourasky Medical Center, Nano24med Coronavirus Disease 2019 (COVID-19); Respiratory Distress Syndrome, Adult Details
AI-071 AI-071 Phase 1 Clinical Oncoimmune-Guangzhou Neoplasms; Coronavirus Disease 2019 (COVID-19) Details
ONC-841 ONC-841 Phase 1 Clinical Oncoimmune-Guangzhou Solid tumours; Neoplasms Details

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