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Your Position: Start > VEGF165

VEGF165

Brief Information

Name:Vascular endothelial growth factor A
Target Synonym:Vascular Endothelial Growth Factor,VEGF-A,MVCD1,Vascular endothelial growth factor A,VEGF,VEGFA,VPF,Vascular Endothelial Growth Factor A165,Vascular permeability factor,Vascular Endothelial Growth Factor A121
Number of Launched Drugs:40
Number of Drugs in Clinical Trials:63
Lastest Research Phase:Approved

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Kat. Nr. Arten Produktbeschreibung Struktur Reinheit Merkmal
GMP-VE5H23 Human GMP Human VEGF165 Protein
GMP-VE5H23-structure
GMP-VE5H23-sds
EP-137 Human VEGFA : VEGFR2 [Biotinylated] Inhibitor Screening ELISA Kit
MBS-K036 Human Human VEGF165-coupled Magnetic Beads
VE5-HF248 Human FITC-Labeled Human VEGF165 Protein, His Tag
VE5-HF248-structure
VE5-HF248-sds
VE5-H82Q0 Human Biotinylated Human VEGF165 Protein, His,Avitag™
VE5-H82Q0-structure
VE5-H82Q0-sds
VE5-H5248 Human Human VEGF165 Protein, His Tag
VE5-H5248-structure
VE5-H5248-sds
VE5-H8210 Human Biotinylated Human VEGF165 Protein, epitope tag free, ultra sensitivity, primary amine labeling
VE5-H8210-structure
VE5-H8210-sds
VE5-H4210 Human Human VEGF165 Protein, premium grade
VE5-H4210-structure
VE5-H4210-sds
ACRO Quality

Part of Bioactivity data

GMP-VE5H23-Cell-based assay
VEGF165 CELL

GMP Human VEGF165 Protein (Cat. No. GMP-VE5H23) stimulates proliferation of 293F-NFAT/Luc-VEGFR2-3-7 cells. The specific activity of GMP Human VEGF165 Protein is＞8.00 X 10^5 IU/mg, which is calibrated against human vascular endothelial growth factor 165 WHO International Standard (NIBSC code: 02/286) (QC tested).

Protocol
VE5-H4210-Cell-based assay
VEGF165 CELL

Human VEGF165, premium grade (Cat. No. VE5-H4210) stimulates proliferation of 293F-NFAT/Luc-VEGFR2-3-7 cells. The specific activity of Human VEGF165, premium grade is＞8.00 x 10^5 IU/mg, which is calibrated against human vascular endothelial growth factor 165 WHO International Standard (NIBSC code: 02/286) (QC tested).

Protocol
VE5-H82Q0-SPR
VEGF165 SPR

Immobilized Biotinylated Human VEGF165, His,Avitag (Cat. No. VE5-H82Q0) on CM5 Chip via Streptavidin, can bind Avastin with an affinity constant of 0.417 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Protocol
VE5-H5248-SPR
VEGF165 SPR

Avastin (Bevacizumab) captured on CM5 chip via ant-human IgG Fc antibodies surface, can bind Human VEGF165 Protein, His Tag (Cat. No. VE5-H5248) with an affinity constant of 1.03 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

Synonym Name

RP1-261G23.1,MGC70609,MVCD1,VEGFA,VPF

Background

VEGF165 is the most abundant splice variant of VEGF-A. VEGF165 is produced by a number of cells including endothelial cells, macrophages and T cells. VEGF165 is involved in angiogenesis, vascular endothelial cell survival, growth, migration and vascular permeability. VEGF gene expression is induced by hypoxia, inflammatory cytokines and oncogenes. VEGF165 binds to heparan sulfate and is retained on the cell surface and in the extracellular matrix. VEGF165 binds to the receptor tyrosine kinases, VEGFR1 and VEGFR2. VEGF165 is the only splice variant that binds to co-receptors NRP-1 and NRP-2 that function to enhance VEGFR2 signaling. Binding of VEGF165 to VEGFR1 and VEGFR2 leads to activation of the PI3K/AKT, p38 MAPK, FAK and paxillin. VEGF plays a key role in tumor angiogenesis in many cancers.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Bevacizumab biosimilar (Qilu Pharma) QL-1101 Approved Qilu Pharmaceutical Co Ltd 安可达 Mainland China Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms Qilu Pharmaceutical Co Ltd 2019-12-06 Neoplasms; Colorectal Neoplasms; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung Details
Bevacizumab biosimilar (Innovent Biologics) IBI-305; IBI305; IBI 305; CHS-305 Approved Innovent Biologics(Suzhou) Co Ltd 达攸同, BYVASDA, Bevagen Mainland China Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms Innovent Biologics(Suzhou) Co Ltd 2020-06-17 Ovarian Neoplasms; Glioblastoma; Carcinoma, Ovarian Epithelial; Triple Negative Breast Neoplasms; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Uterine Cervical Neoplasms Details
Bevacizumab biosimilar (Pfizer) PF-6439535; PF-06439535 Approved Pfizer Inc Zirabev EU Carcinoma, Renal Cell; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Fallopian Tube Neoplasms Pfizer Europe Ma Eeig 2019-02-14 Ovarian Neoplasms; Carcinoma, Renal Cell; Glioblastoma; Carcinoma, Ovarian Epithelial; Breast Neoplasms; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Bevacizumab biosimilar (Elea) Approved Laboratorio Elea Phoenix Sa Lumiere Argentina Macular Degeneration Laboratorio Elea Phoenix Sa 2018-04-26 Macular Degeneration Details
Bevacizumab biosimilar (Samsung Bioepis) SP-8; SB-8 Approved Samsung Bioepis Co Ltd Aybintio EU Fallopian Tube Neoplasms; Carcinoma, Ovarian Epithelial; Carcinoma, Non-Small-Cell Lung; Peritoneal Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Renal Cell Samsung Bioepis Nl Bv 2020-08-19 Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Small Cell Lung Carcinoma; Breast Neoplasms; Peritoneal Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Ranibizumab biosimilar (Samsung Bioepis) AM002; SB-11; SB11 Approved Samsung Bioepis Co Ltd BYOOVIZ EU Macular Edema; Wet Macular Degeneration; Retinal Vein Occlusion; Choroidal Neovascularization; Diabetic macular oedema; Diabetic Retinopathy Samsung Bioepis Nl Bv 2021-08-18 Macular Edema; Diabetic macular oedema; Wet Macular Degeneration; Macular Degeneration; Diabetic Retinopathy; Choroidal Neovascularization; Retinal Vein Occlusion Details
Bevacizumab biosimilar (Intas Pharmaceuticals) INTP-24 Approved Intas Biopharmaceuticals Bevatas India Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Uterine Cervical Neoplasms; Glioblastoma; Carcinoma, Renal Cell; Breast Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms Intas Biopharmaceuticals 2017-10-04 Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Glioblastoma; Breast Neoplasms; Peritoneal Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Ranibizumab biosimilar (Formycon/Bioeq) FYB-201 Approved Bioeq Gmbh CIMERLI, Ranivisio United States Wet Macular Degeneration; Diabetic macular oedema; Macular Degeneration; Macular Edema; Retinal Vein Occlusion; Choroidal Neovascularization; Diabetic Retinopathy Coherus Biosciences Inc 2022-08-02 Macular Edema; Wet Macular Degeneration; Diabetic macular oedema; Diabetes Complications; Macular Degeneration; Retinal Vein Occlusion; Choroidal Neovascularization; Diabetic Retinopathy Details
Bevacizumab biosimilar (AryoGen Biopharma) BE1040V Approved Aryogen Biopharma Stivant Iran Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Colorectal Neoplasms; Uterine Cervical Neoplasms; Metastatic breast cancer; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Glioblastoma Aryogen Biopharma 2019-06-01 Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Glioblastoma; Colorectal Neoplasms; Peritoneal Neoplasms; Metastatic breast cancer; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Bevacizumab biosimilar (Zydus Cadila) Approved Zydus Cadila Bryxta India Carcinoma, Non-Small-Cell Lung; Fallopian Tube Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Colorectal Neoplasms; Glioblastoma; Metastatic breast cancer; Carcinoma, Renal Cell Zydus Cadila 2017-01-01 Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Glioblastoma; Peritoneal Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Metastatic breast cancer; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Bevacizumab biosimilar (TOT Biopharm) TAB-008; TOT-102; TAB008; TOT102 Approved 朴欣汀, Pusintin Mainland China Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Tot Biopharm Co Ltd 2021-12-01 Carcinoma, Ovarian Epithelial; Glioblastoma; Peritoneal Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Bevacizumab G180CU; RO-4876646; RG-435; NSC-704865; G180CL; R-435; G180DL Approved Genentech Inc 安维汀, Avastin United States Colorectal Neoplasms Genentech Inc 2004-02-26 Solid tumours; Liver Neoplasms; Ovarian Neoplasms; Recurrence; Infections; Respiratory Tract Infections; Pterygium; Leukemia; Arteriovenous Malformations; Ependymoma; Telangiectasia, Hereditary Hemorrhagic; HIV Infections; Leukemia, Myelogenous, Chronic; Kidney Neoplasms; Epistaxis; Head and Neck Neoplasms; Leiomyosarcoma; Fibrosarcoma; Telangiectasis; Meningeal Carcinomatosis; Rectal Neoplasms; Vaginal Neoplasms; Esophageal Neoplasms; Macular Edema; Anaplasia; Carcinoma, Renal Cell; Diabetes Mellitus, Type 2; Squamous Cell Carcinoma of Head and Neck; Abdominal Neoplasms; Granuloma, Lethal Midline; Hemangioblastoma; Carcinoma; Carcinoma, Basal Cell; Esthesioneuroblastoma, Olfactory; Carcinoid Tumor; Carcinoma, Ovarian Epithelial; Glioblastoma; Neurofibromatosis 2; Pancreatic Neoplasms; Neoplasms, Glandular and Epithelial; Virus Diseases; Papillomavirus Infections; Neoplasms, Squamous Cell; Respiratory Tract Diseases; Neoplasms; Small Cell Lung Carcinoma; Myelodysplastic Syndromes; Triple Negative Breast Neopl Details
Bevacizumab biosimilar(Dr. Reddy's Laboratories) DRL-BZ Approved Dr.Reddy's Laboratories Ltd Versavo, Persivia India Fallopian Tube Neoplasms; Uterine Cervical Neoplasms; Glioblastoma; Peritoneal Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Ovarian Epithelial; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell Dr.Reddy's Laboratories Ltd 2019-08-19 Ovarian Neoplasms; Carcinoma, Renal Cell; Glioblastoma; Carcinoma, Ovarian Epithelial; Breast Neoplasms; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Bevacizumab biosimilar (Celltrion) CTP-16; CT-16; CT-P16 Approved Celltrion Inc Vegzelma EU Carcinoma, Renal Cell; Peritoneal Neoplasms; Ovarian Neoplasms; Carcinoma, Non-Small-Cell Lung; Fallopian Tube Neoplasms; Uterine Cervical Neoplasms; Breast Neoplasms; Colorectal Neoplasms Celltrion Healthcare Hungary Kft 2022-08-17 Ovarian Neoplasms; Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Glioblastoma; Breast Neoplasms; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Aflibercept biosimilar (Momenta/Mylan) M-710; MYL-1701P Approved Momenta, Mylan Nv EU Diabetes Complications; Myopia, Degenerative; Diabetic Retinopathy; Macular Edema; Retinal Vein Occlusion Viatris Ltd 2023-09-15 Macular Edema; Myopia, Degenerative; Diabetic macular oedema; Diabetes Complications; Diabetic Retinopathy; Retinal Vein Occlusion Details
Ranibizumab biosimilar (Intas Biopharmaceuticals) Approved Intas Biopharmaceuticals Razumab India Macular Degeneration Intas Biopharmaceuticals 2015-01-01 Macular Degeneration Details
Ranibizumab biosimilar (Xbrane) Approved Xbrane Biopharma Ab EU Diabetic Retinopathy; Macular Edema; Wet Macular Degeneration; Diabetes Complications Stada Arzneimittel Ag 2022-11-09 Macular Edema; Wet Macular Degeneration; Diabetes Complications; Macular Degeneration; Diabetic Retinopathy Details
Bevacizumab biosimilar (Boan Biopharma) LY-01008 Approved 博优诺, Boyounuo Mainland China Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms Shandong Boan Biotechnology Co Ltd 2021-05-07 Carcinoma, Ovarian Epithelial; Glioblastoma; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Carcinoma, Hepatocellular Details
Bevacizumab biosimilar (Shanghai Henlius Biotech) HLX-04; HLX04-O Approved Shanghai Henlius Biotech Inc 汉贝泰 Mainland China Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Shanghai Henlius Biopharmaceuticals Co Ltd 2021-11-30 Solid tumours; Carcinoma; Rectal Neoplasms; Carcinoma, Ovarian Epithelial; Glioblastoma; Wet Macular Degeneration; Peritoneal Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Macular Degeneration; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details
Bevacizumab biosimilar (Biocad) BCD-021 Approved Biocad Avegra Russian Federation Glioblastoma; Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Fallopian Tube Neoplasms; Peritoneal Neoplasms; Uterine Cervical Neoplasms Biocad 2015-11-25 Carcinoma, Renal Cell; Glioblastoma; Carcinoma, Ovarian Epithelial; Breast Neoplasms; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Macular Degeneration; Uterine Cervical Neoplasms Details
Bevacizumab biosimilar (Sinocelltech) SCT-510; SCT510A; SCT-510A Approved SinoCelltech Ltd 安贝珠 Mainland China Peritoneal Neoplasms; Uterine Cervical Neoplasms; Ovarian Neoplasms; Fallopian Tube Neoplasms; Glioblastoma; Colorectal Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung SinoCelltech Ltd 2023-06-27 Ovarian Neoplasms; Glioblastoma; Carcinoma, Ovarian Epithelial; Wet Macular Degeneration; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Macular Degeneration; Uterine Cervical Neoplasms; Carcinoma, Hepatocellular Details
Ranibizumab biosimilar (Qilu Pharmaceutical) BCD-300; QL-1205 Approved Biocnd, Qilu Pharmaceutical Co Ltd Rimmyrah EU Myopia, Degenerative; Choroidal Neovascularization; Diabetes Complications; Macular Edema; Wet Macular Degeneration Qilu Pharma Spain Sa 2024-01-05 Macular Edema; Myopia, Degenerative; Wet Macular Degeneration; Diabetic macular oedema; Diabetes Complications; Retinal Vein Occlusion; Macular Degeneration; Choroidal Neovascularization; Diabetic Retinopathy; Myopia Details
Bevacizumab biosimilar (Allergan/Amgen) ABP-215 Approved Amgen Inc Mvasi United States Glioblastoma; Carcinoma, Renal Cell; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Amgen Inc 2017-09-14 Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Glioblastoma; Breast Neoplasms; Peritoneal Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Aflibercept biosimilar (Qilu Pharmaceutical) QL-1207 Approved Qilu Pharmaceutical Co Ltd Mainland China Macular Degeneration; Diabetic macular oedema Qilu Pharmaceutical Co Ltd 2023-12-13 Diabetic macular oedema; Macular Degeneration Details
Ranibizumab biosimilar (Senju) GBS-007; OT-701; SJP-0133 Approved Senju Pharmaceutical Co Ltd Japan Macular Degeneration Senju Pharmaceutical Co Ltd 2021-09-27 Wet Macular Degeneration; Macular Degeneration Details
Bevacizumab biosimilar (mAbixience) MB02; BEVZ-92; BEVZ92-MB02; AP-01 Approved Mabxience Sa Alymsys Argentina Colorectal Neoplasms; Carcinoma, Renal Cell; Peritoneal Neoplasms; Carcinoma, Non-Small-Cell Lung; Breast Neoplasms; Fallopian Tube Neoplasms; Uterine Cervical Neoplasms Stada Arzneimittel Ag 2013-10-25 Carcinoma, Renal Cell; Glioblastoma; Carcinoma, Ovarian Epithelial; Breast Neoplasms; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Neovasculgen PI-VEGF165 Approved Human Stem Cells Institute Neovasculgen Russian Federation Peripheral Arterial Disease Human Stem Cells Institute 2011-12-07 Peripheral Arterial Disease; Peripheral Nerve Injuries Details
Bevacizumab biosimilar (CTTQ Pharma) TQ-B2302 Approved Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd 安倍斯 Mainland China Glioblastoma; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Nanjing Shunxin Pharmaceuticals Co Ltd Of Chiatai Tianqing Pharmaceutical Group 2023-02-28 Ovarian Neoplasms; Glioblastoma; Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Bevacizumab biosimilar (Biocon/Mylan) MYL-1402O Approved Biocon Ltd Lextemy, KRABEVA, Abevmy India Carcinoma, Renal Cell; Colorectal Neoplasms; Ovarian Neoplasms; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Mylan Pharmaceuticals Private Ltd 2017-11-27 Ovarian Neoplasms; Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Breast Neoplasms; Brain Neoplasms; Peritoneal Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Conbercept FP-3; KH-902 Approved Chengdu Kanghong Biotechnologies Co Ltd 朗沐, Langmu Mainland China Macular Degeneration Chengdu Kanghong Biotechnologies Co Ltd 2013-11-27 Macular Edema; Vision Disorders; Wet Macular Degeneration; Diabetic macular oedema; Retinoblastoma; Hemangioma; Uveitis; Retinal Vein Occlusion; Choroidal Neovascularization; Corneal Neovascularization; Diabetes Mellitus; Macular Degeneration Details
Bevacizumab biosimilar(Apotex ) Approved Apotex Inc BAMBEVI Canada Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Glioblastoma; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Apotex Inc 2021-09-23 Carcinoma, Ovarian Epithelial; Glioblastoma; Peritoneal Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Aflibercept BAY-865321; BAT-86-5321 Approved Bayer AG Eylea, 艾力雅 United States Macular Degeneration; Macular Edema Regeneron Pharmaceuticals Inc 2011-11-18 Retinitis Pigmentosa; Choroidal Neovascularization; Carcinoma, Non-Small-Cell Lung; Corneal Neovascularization; Retinopathy of Prematurity; Neoplasm Metastasis; Diabetic Retinopathy; Retinal Vein Occlusion; Macular Degeneration; Vitreous Hemorrhage; Lymphoma, Non-Hodgkin; Retinal Degeneration; Eye Diseases; Diabetes Complications; Colorectal Neoplasms; Prostatic Neoplasms; Diabetes Mellitus, Type 1; Wet Macular Degeneration; Diabetic macular oedema; Multiple Myeloma; Myopia, Degenerative; Retinal Diseases; Colonic Neoplasms; Central Serous Chorioretinopathy; Neoplasms; Diabetes Mellitus, Type 2; Rectal Neoplasms; Choroid Diseases; Glaucoma, Neovascular; Macular Edema; Cataract Details
Bevacizumab biosimilar (Jiangsu Hengrui Medicine) BP-102 Approved Jiangsu Hengrui Medicine Co Ltd 艾瑞妥 Mainland China Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms Suzhou Suncadia Biopharmaceuticals Co Ltd 2021-06-22 Solid tumours; Triple Negative Breast Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Ziv-aflibercept BAY-865321; AVE-0005 Approved Sanofi Zaltrap United States Colorectal Neoplasms Sanofi-Aventis U.S. Llc 2012-08-03 Lymphoma; Breast Neoplasms; Urethral Neoplasms; Brain Neoplasms; Colorectal Neoplasms; Genital Neoplasms, Female; Carcinoma, Mucoepidermoid; Gliosarcoma; Astrocytoma; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Peritoneal Neoplasms; Ureteral Neoplasms; Lung Neoplasms; Prostatic Neoplasms; Uterine Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Neuroendocrine; Glioma; Lymphoma, Non-Hodgkin; Thyroid Neoplasms; Carcinoma, Squamous Cell; Retinal Vein Occlusion; Neoplasm Metastasis; Melanoma; Carcinoma, Non-Small-Cell Lung; Glioblastoma; Solid tumours; Leiomyosarcoma; Multiple Endocrine Neoplasia Type 1; Leukemia; Carcinoma; Carcinoma, Renal Cell; Carcinoid Tumor; Rectal Neoplasms; Neoplasms; Carcinoma, Ovarian Epithelial; Pancreatic Neoplasms; Leukemia, Myelomonocytic, Chronic; Ovarian Neoplasms; Myelodysplastic Syndromes; Myeloproliferative Disorders; Carcinoma, Transitional Cell; Carcinoma, Papillary; Small Cell Lung Carcinoma; Colonic Neoplasms; Ascites; Lung Diseases; Adenoc Details
Ranibizumab RG-3645; rhu-Fab-VEG; AMD-rhuFab-V2; AMD-Fab; rhuFab-V2; RFB-002; Y-0317; RG-6321 Approved Novartis Pharma Ag, Genentech Inc Lucentis, 诺适得, Susvimo United States Macular Degeneration Genentech Inc 2006-06-30 Retinal Degeneration; Wet Macular Degeneration; Retinoblastoma; Vascular Diseases; Glaucoma; Retinal Detachment; Diabetes Complications; Pseudoxanthoma Elasticum; Retinal Neovascularization; Cardiovascular Diseases; Eye Diseases; Uveitis; Ischemia; Vitreous Hemorrhage; Hemangioma; Retinopathy of Prematurity; Diabetic Retinopathy; Choroidal Neovascularization; Retinal Vein Occlusion; Macular Degeneration; Melanoma; Conjunctival Neoplasms; Port-Wine Stain; Corneal Neovascularization; von Hippel-Lindau Disease; Myopia; Diabetes Mellitus; Telangiectasis; Cataract; Pterygium; Polypoidal choroidal vasculopathy; Diabetic Angiopathies; Retinal Telangiectasis; Vitreous Detachment; Epistaxis; Telangiectasia, Hereditary Hemorrhagic; Iris Diseases; Vision Disorders; Macular Edema; Glaucoma, Neovascular; Optic Neuropathy, Ischemic; Strongyloidiasis; Neovascularization, Pathologic; Depression; Central Serous Chorioretinopathy; Histoplasmosis; Retinal Diseases; Angioid Streaks; Myopia, Degenerative; Pathologic Processes; Mu Details
Bevacizumab biosimilar (Reliance Life Sciences) R-TPR-023 Approved Reliance Life Sciences BevaciRel India Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Glioblastoma; Carcinoma, Renal Cell; Fallopian Tube Neoplasms; Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Uterine Cervical Neoplasms Reliance Life Sciences Pvt Ltd 2016-06-13 Carcinoma, Renal Cell; Glioblastoma; Carcinoma, Ovarian Epithelial; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Faricimab RO-6867461; RG-7716 Approved F. Hoffmann-La Roche Ltd, Genentech Inc Vabysmo, 罗视佳 United States Diabetic macular oedema; Wet Macular Degeneration Genentech Inc 2022-01-28 Polypoidal choroidal vasculopathy; Macular Edema; Choroid Diseases; Vision Disorders; Retinal Diseases; Diabetic macular oedema; Wet Macular Degeneration; Diabetes Complications; Macular Degeneration; Diabetes Mellitus; Retinal Vein Occlusion; Diabetic Retinopathy; Choroidal Neovascularization Details
Bevacizumab biosimilar (Hetero Drugs) Approved Hetero Drugs Ltd Cizumab India Colorectal Neoplasms Hetero Drugs Ltd 2016-06-27 Colorectal Neoplasms Details
Bevacizumab biosimilar (Bio-Thera Solutions) BAT-1706 Approved Bio-Thera Solutions Ltd 普贝希, AVZIVI Mainland China Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms Bio-Thera Solutions Ltd, Beigene Ltd 2021-11-17 Ovarian Neoplasms; Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Glioblastoma; Neoplasms; Breast Neoplasms; Peritoneal Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Carcinoma, Hepatocellular Details
Bevacizumab biosimilar (Betta/Mabworks) MIL-60 Approved Institute Of Basic Medicine, Chinese Academy Of Medical Sciences, Beijing Mabworks Biotech Co Ltd 贝安汀 Mainland China Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Betta Pharmaceuticals Co Ltd 2021-11-24 Carcinoma, Ovarian Epithelial; Glioblastoma; Peritoneal Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Bevacizumab biosimilar(Jiangsu Aosaikang) ASK-1202; AMD-B; AK-3008; ASK-B1202; ASKB1202 Phase 3 Clinical Jiangsu Aosaikang Pharmaceutical Co Ltd Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Ranibizumab biosimilar (Reliance Life Sciences Group) R-TPR-024 Phase 3 Clinical Reliance Life Sciences Macular Degeneration Details
TR-009 NOV-1501; ABL001-ABL Bio; ABL-001-ABL Bio; ES-104; CTX-009; HD-B001A; HDB001A; TR-009 Phase 3 Clinical Abl Bio Inc Biliary Tract Neoplasms; Solid tumours; Rectal Neoplasms; Colonic Neoplasms; Neoplasms; Cholangiocarcinoma; Bile Duct Neoplasms; Colorectal Neoplasms; Gallbladder Neoplasms Details
Bevacizumab biosimilar (Fudan-Zhangjiang) Phase 3 Clinical Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd Colorectal Neoplasms; Macular Degeneration; Carcinoma, Non-Small-Cell Lung Details
Aflibercept Biosimilar (Alteogen) ALT-L9 Phase 3 Clinical Alteogen Inc, Kissei Pharmaceutical Co Ltd Macular Degeneration Details
Bevacizumab biosimilar (Huaota Biopharm/Shanghai Junshi Biosciences) JS-501; HOT-1010 Phase 3 Clinical Shanghai Huaota Biopharmaceutical Co Ltd Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Bevacizumab biosimilar (Prestige BioPharma/Hanwha Biologics) HD-204 Phase 3 Clinical Hanwha Biologics Small Cell Lung Carcinoma; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Bevacizumab biosimilar (Oncobiologics) ONS-5010; ONS-1045 Phase 3 Clinical Outlook Therapeutics Inc Diabetic macular oedema; Wet Macular Degeneration; Retinal Vein Occlusion; Macular Degeneration Details
Aflibercept biosimilar (CinnaGen) Phase 3 Clinical Cinnagen Macular Degeneration Details
Bevacizumab biosimilar (Alphamab/R-Pharm) RPH-001 Phase 3 Clinical Suzhou Alphamab Co Ltd, R-Pharm Colorectal Neoplasms Details
Bevacizumab biosimilar(Zhejiang Teruisi Pharmaceutical) TRS-003 Phase 3 Clinical Zhejiang Teruisi Pharmaceutical Inc Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Ranibizumab biosimilar (Chong Kun Dang Pharmaceutical) CKD-701 Phase 3 Clinical Chong Kun Dang Pharmaceutical Corp Macular Degeneration Details
Ranibizumab biosimilar (Lupin) LUBT-010 Phase 3 Clinical Lupin Ltd Macular Degeneration Details
Abicipar pegol MP-0112; AGN-150998 Phase 3 Clinical Molecular Partners Ag Macular Edema; Diabetic macular oedema; Macular Degeneration Details
Bevacizumab biosimilar (Genor Biopharma) GB-222 Phase 3 Clinical Genor Biopharma Co Ltd Brain Neoplasms; Glioma; Carcinoma, Non-Small-Cell Lung Details
Muparfostat sodium PI-88 Phase 3 Clinical Australian National University Solid tumours; Liver Neoplasms; Neoplasms; Small Cell Lung Carcinoma; Prostatic Neoplasms; Lung Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Melanoma Details
Aflibercept biosimilar (Amgen) ABP-938 Phase 3 Clinical Amgen Inc Vascular Diseases; Macular Degeneration Details
Bevacizumab biosimilar (Centus Biotherapeutics) FKB-238 Phase 3 Clinical Fujifilm Kyowa Kirin Biologics Co Ltd Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Breast Neoplasms; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Bevacizumab biosimilar(Laboratorios Sophia) PRO-169 Phase 3 Clinical Laboratorios Sophia Sa De Cv Diabetic macular oedema Details
Aflibercept Biosimilar(Alvotech Swiss) AVT-06 Phase 3 Clinical Alvotech Swiss Ag Vascular Diseases; Macular Degeneration Details
Aflibercept biosimilar (HEXAL/Sandoz) SOK-583A1; SOK583A1; SOK-583 Phase 3 Clinical Sandoz, Hexal Macular Degeneration Details
CT-P42 CT-P42 Phase 3 Clinical Celltrion Inc Macular Edema; Diabetic macular oedema Details
Aflibercept biosimilar (Mabwell) 9-MW-0813; 9MW-0813; 9MW0813; 9-MW0813 Phase 3 Clinical Mabwell (Shanghai) Bioscience Co Ltd Diabetic macular oedema Details
Bevacizumab biosimilar (Beijing Science Sun/Beijing Lvzhu) K-11 Phase 3 Clinical Beijing Lvzhu Biological Technology Co Ltd, Beijing Science Sun Pharmaceutical Co Ltd Liver Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details
FYB-203 FYB-203 Phase 3 Clinical Macular Degeneration Details
Aflibercept biosimilar (Sam Chun Dang Pharm) SCD-411 Phase 3 Clinical Sam Chun Dang Pharm Co Ltd Wet Macular Degeneration; Macular Degeneration Details
Aflibercept biosimilar (Samsung Bioepis) SB-15; AM003; SB15 Phase 3 Clinical Samsung Bioepis Co Ltd Solid tumours; Wet Macular Degeneration; Diabetic macular oedema; Macular Degeneration Details
Aflibercept Biosimilar (Boan Biopharma/Luye Pharma） LY-09004; BA-9101; OT-702 Phase 3 Clinical Luye Pharma Group Ltd Wet Macular Degeneration; Macular Degeneration Details
Varisacumab R-84; GNR-011; AT-001-IBCG Phase 3 Clinical Peregrine, The University Of Texas Southwestern Medical Center Glioblastoma; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
MP-0250 MP-0250 Phase 2 Clinical Molecular Partners Ag Neoplasms; Multiple Myeloma; Carcinoma, Non-Small-Cell Lung Details
ALS-L1023 ALS-L1023 Phase 2 Clinical Angiolab Inc Sleep Bruxism; Metabolic Dysfunction-Associated Steatotic Liver Disease; Metabolic Syndrome; Temporomandibular Joint Disorders; Macular Degeneration Details
Bevacizumab biosimilar (Eastern Biotech) JY-028 Phase 2 Clinical Beijing Eastern Biotech Co Ltd Wet Macular Degeneration; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Macular Degeneration Details
Intravitreal ranibizumab (Sultan Qaboos University) Phase 2 Clinical Sultan Qaboos University Retinal Dystrophies Details
ELGN-EYE ELGN-EYE Phase 2 Clinical Elgan Pharma Ltd Retinopathy of Prematurity Details
SCT-501(National Cancer Institute) SCT-501 Phase 2 Clinical National Cancer Institute Kidney Neoplasms Details
Y-400 Y-400 Phase 2 Clinical Wuhan Yzy Biopharma Co Ltd Wet Macular Degeneration; Diabetic macular oedema; Macular Degeneration Details
BI-836880 BI-836880 Phase 2 Clinical Ablynx Nv Neoplasms; Wet Macular Degeneration Details
SYB-509 SYB-509 Phase 1 Clinical Sichuan Yuanda Shuyang Pharmaceutical Co Ltd Carcinoma, Transitional Cell; Carcinoma, Hepatocellular Details
Vanucizumab RG-7221; RO-5520985; B800Z06O8K (UNII code) Phase 1 Clinical F. Hoffmann-La Roche Ltd Solid tumours; Neoplasms; Colorectal Neoplasms Details
Bevacizumab biosimilar (North China Pharmaceutical) MG-021 Phase 1 Clinical North China Pharmaceutical Company Ltd Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Macular Degeneration Details
Bevacizumab biosimilar(Guilin Sanjin) Phase 1 Clinical Guilin Sanjin Pharmaceutical Co Ltd Macular Degeneration Details
Ranibizumab biosimilar (CJSC Generium) GNR-067 Phase 1 Clinical Cjsc Generium Macular Degeneration Details
Bevacizumab biosimilar (Shanghai Kangdai) Phase 1 Clinical Shanghai Kanda Bio-Technology Co Ltd Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Bevacizumab biosimilar (JHL Biotech) JHL-1149 Phase 1 Clinical JHL Biotech Neoplasms Details
Ziv-aflibercept biosimiliar (Boan Biopharma) LY-01012; BA-1103 Phase 1 Clinical Colorectal Neoplasms Details
Bevacizumab biosimilar (Tanvex BioPharma) TX-16 Phase 1 Clinical Tanvex Biopharma Colorectal Neoplasms Details
PB-101 PB-101 Phase 1 Clinical Panolos Bioscience Inc Solid tumours; Stomach Neoplasms; Neoplasms; Colorectal Neoplasms; Carcinoma, Hepatocellular Details
IBI-333 IBI-333 Phase 1 Clinical Innovent Biologics (Usa), Inc Wet Macular Degeneration; Macular Degeneration Details
IBI-324 IBI-324 Phase 1 Clinical Innovent Biologics (Usa), Inc Diabetic macular oedema Details
Y-332 Y-332 Phase 1 Clinical CSPC Pharmaceutical Group Ltd, Wuhan Yzy Medical Science And Technology Co Ltd Solid tumours Details
Dilpacimab ABT-165; DVD-Ig ABT-165 Phase 1 Clinical Abbvie Inc Solid tumours; Neoplasms Details
Bevacizumab biosimilar (Gedeon Richter) Phase 1 Clinical Gedeon Richter Plc Neoplasms Details
HG-202 HG-202; HG202 Phase 1 Clinical HuiGene Therapeutics Ltd Wet Macular Degeneration; Macular Degeneration Details
Aflibercept biosimilar (Zein Bioteccnology) Phase 1 Clinical Zein Bioteccnology Co Ltd Diabetic macular oedema Details
VEGFA-targeting Gene Therapy(BDgene) BD311 Phase 1 Clinical Shanghai BDgene Technology Co Ltd Diabetic macular oedema; Macular Degeneration; Retinal Vein Occlusion Details
ASKG-712 ASKG-712; AM-712 Phase 1 Clinical Askgene Pharma Diabetic macular oedema; Wet Macular Degeneration; Macular Degeneration Details
OB-318 OB-318 Phase 1 Clinical Oneness Biotech Co Ltd Solid tumours; Carcinoma, Hepatocellular Details
Bevacizumab biosimilar(Guangdong Dongyangguang) Phase 1 Clinical Guangdong Dongyangguang Pharmaceutical Co Ltd Carcinoma, Non-Small-Cell Lung Details
Colorectal cancer vaccine (Immunovo/Pepscan Therapeutics) Phase 1 Clinical Pepscan Systems Colorectal Neoplasms Details
Bevacizumab biosimilar(Bioxpress) BXT-2316 Clinical Bioxpress Therapeutics Sa Carcinoma, Renal Cell; Glioblastoma; Carcinoma, Ovarian Epithelial; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details

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