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B18R

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B1R-H52H6 Vaccinia Virus Vaccinia Virus B18R Protein, His Tag
B1R-H52H6-structure
B1R-H52H6-sds
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Part of Bioactivity data

B1R-H52H6-SPR
B18R ELISA

Immobilized human IFN-α1a(106-01) at 2 μg/mL (100 μL/well) can bind Vaccinia Virus B18R, His Tag (Cat. No. B1R-H52H6) with a linear range of 3-13 ng/mL (QC tested).

Protocol

Synonym Name

B18R

Background

B18R is a type I interferon (IFN)-binding protein and it is encoded by the B18R open reading frame in the WR (Western Reserve) strain of vaccinia virus, which contains two Ig-like C2-type domains and one Ig-like V-type domain. B18R exists in a soluble and a membrane-bound form. As a type I IFN receptor, B18R counteracts the antiviral effects of host IFN-alpha/beta. Also, B18R acts as a soluble IFN-alpha receptor and thus inhibits the interaction between host IFN-alpha and its receptor.

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