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IL-21

Brief Information

Name:Interleukin-21
Target Synonym:Za11,IL-21,CVID11,Interleukin-21 Isoform,Interleukin 21
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

GMP-L21H25-Cell-based assay
 IL-21 CELL

GMP Human IL-21 Protein (Cat. No. GMP-L21H25) stimulates secretion of IFN-γ by NK-92 human natural killer lymphoma cells stimulated with 10 ng/mL GMP Human IL-15 Protein (Cat. No. GMP-L15H13). The specific activity of GMP Human IL-21 Protein (Cat. No. GMP-L21H25) is > 1.00×10^5 U/mg (QC tested).

IL1-H5213-Cell-based assay
 IL-21 CELL

Human IL-21, premium grade (Cat. No. IL1-H5213) stimulates secretion of IFN-γ by NK-92 human natural killer lymphoma cells stimulated with 10 ng/mL Human IL-15, premium grade (Cat. No. IL5-H4117). The specific activity of Human IL-21, premium grade (Cat. No. IL1-H5213) is > 1.00×10^5 U/mg (QC tested).

IL1-H82F7-SPR
 IL-21 SPR

Biotinylated Human IL-21, Fc,Avitag, premium grade (Cat. No. IL1-H82F7) immobilized on CM5 Chip can bind Human IL-21 R, Fc Tag (Cat. No. ILR-H5257) with an affinity constant of 0.165 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

IL1-C52H9-ELISA
 IL-21 ELISA

Immobilized Cynomolgus IL-21, His Tag (Cat. No. IL1-C52H9) at 5 μg/mL (100 μL/well) can bind Cynomolgus IL-21 R, Fc Tag (Cat. No. ILR-C5259) with a linear range of 1-20 ng/mL (QC tested).

Synonym Name

IL21,Za11,Interleukin-21

Background

Interleukin-21 (IL-21) is a secreted protein which belongs to the IL-15 / IL-21 family. Interleukin-21 / IL-21 belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL21R) and the common cytokine receptor gamma chain (gamma(C)). Interleukin-21 / IL-21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. The IL-21R is widely distributed on lympho-haematopoietic cells.  IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
hV-01 hV-01 Phase 1 Clinical Hangzhou Converd Co Ltd Solid tumours Details
NN-9828 NN-8828; NN-9828; Anti-IL21; NNC114-0005; NNC0114-0006; NNC-0114-0000-0005 Phase 2 Clinical Bristol-Myers Squibb Company Diabetes Mellitus, Type 1; Arthritis, Rheumatoid; Lupus Erythematosus, Systemic; Inflammation; Diabetes Mellitus; Crohn Disease Details
Avizakimab BOS-161721 Phase 2 Clinical Medimmune, Boston Pharmaceuticals Inc Lupus Erythematosus, Systemic Details
IL-21 mab (Lilly) Phase 1 Clinical Eli Lilly And Company Immune System Diseases Details

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