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Carbonic Anhydrase IX

Brief Information

Name:Carbonic anhydrase IX
Target Synonym:EC:4.2.1.1,Renal cell carcinoma-associated antigen G250,P54/58N,CA9,Carbonic Anhydrase 9,RCC-Associated Protein G250,Carbonate Dehydratase IX,Carbonic Dehydratase,CA-IX,CAIX,PMW1,MN,EC 4.2.1.1,G250,Carbonic anhydrase IX,Membrane antigen MN,RCC-associated antigen G250
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:10
Lastest Research Phase:Phase 3 Clinical

Product ListCompare or Buy

Kat. Nr. Arten Produktbeschreibung Struktur Reinheit Merkmal
CA9-HA2H7 Human APC-Labeled Human Carbonic Anhydrase IX / CA9 (38-414) Protein, His Tag (Site-specific conjugation)
CA9-HA2H7-structure
CA9-C52H3 Cynomolgus Cynomolgus Carbonic Anhydrase IX Protein, His Tag (MALS verified)
CA9-C52H3-structure
CA9-C52H3-sds
CA9-H82F5 Human Biotinylated Human Carbonic Anhydrase IX / CA9 (38-414) Protein, Fc,Avitag™ (MALS verified)
CA9-H82F5-structure
CA9-H82F5-sds
CA9-HF228 Human FITC-Labeled Human Carbonic Anhydrase IX / CA9 (38-414) Protein, His Tag (MALS verified)
CA9-HF228-structure
CA9-HF228-sds
CA9-HP2H6 Human PE-Labeled Human Carbonic Anhydrase IX / CA9 (38-414) Protein, His Tag (Site-specific conjugation)
CA9-HP2H6-structure
CA9-C82E6 Cynomolgus Biotinylated Cynomolgus Carbonic Anhydrase IX / CA9 (38-398) Protein, His,Avitag™ (MALS verified)
CA9-C82E6-structure
CA9-C82E6-sds
CA9-H5253 Human Human Carbonic Anhydrase IX / CA9 (38-414) Protein, Fc Tag (MALS verified)
CA9-H5253-structure
CA9-H5253-sds
CA9-M52H3 Mouse Mouse Carbonic Anhydrase IX / CA9 (32-390) Protein, His Tag (MALS verified)
CA9-M52H3-structure
CA9-M52H3-sds
CA9-H82E3 Human Biotinylated Human Carbonic Anhydrase IX / CA9 (38-414) Protein, His,Avitag™ (MALS verified)
CA9-H82E3-structure
CA9-H82E3-sds
CA9-H5220 Human Human Carbonic Anhydrase IX / CA9 (138-414) Protein, His Tag (MALS verified)
CA9-H5220-structure
CA9-H5220-sds
CA9-H5226 Human Human Carbonic Anhydrase IX / CA9 (38-414) Protein, His Tag (active enzyme, MALS verified)
CA9-H5226-structure
CA9-H5226-sds
ACRO Quality

Part of Bioactivity data

CA9-HA2H7-Cell-based assay
 Carbonic Anhydrase IX FACS

5e5 of anti-Carbonic Anhydrase IX CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of APC-Labeled Human Carbonic Anhydrase IX (38-414) Protein, His Tag (Cat. No. CA9-HA2H7) and negative control protein respectively. APC signal was used to evaluate the binding activity (QC tested).

CA9-HP2H6-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

5e5 of anti-Carbonic Anhydrase IX CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human Carbonic Anhydrase IX (38-414), His Tag (Cat. No. CA9-HP2H6) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

CA9-HF228-ELISA
 Carbonic Anhydrase IX ELISA

Immobilized Anti-Carbonic Anhydrase IX Antibody, Human IgG1 at 1 μg/mL (100 μL/well) can bind FITC-Labeled Human Carbonic Anhydrase IX (38-414), His Tag (Cat. No. CA9-HF228) with a linear range of 0.01-1.25 μg/mL (QC tested).

CA9-C52H3-MALS-HPLC
Carbonic Anhydrase IX MALS images

The purity of Cynomolgus Carbonic Anhydrase IX Protein, His Tag (Cat. No. CA9-C52H3) is more than 90% and the molecular weight of this protein is around 38-48 kDa verified by SEC-MALS.

Synonym Name

CAIX,CA9,CA-IX,G250,MN,P54,58N,pMW1

Background

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes. CAs form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa), a reversible reaction that occurs rather slowly in the absence of a catalyst. One of the functions of the enzyme in animals is to interconvert carbon dioxide and bicarbonate to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide out of tissues. The active site of most carbonic anhydrases contains a zinc ion. There are at least five distinct CA families (α, β, γ, δ and ε). Carbonic anhydrase 9 (CA9 / CAIX) is also known as Membrane antigen MN (MN), Renal cell carcinoma-associated antigen G250, which belongs to the alpha-carbonic anhydrase family. CA9 / CAIX with an optimal activity at pH 6.49. Reversible hydration of carbon dioxide. CA IX participates in pH regulation. CA9 may be involved in the control of cell proliferation and transformation. CA-IX appears to be a novel specific biomarker for a cervical neoplasia.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
[177Lu]Lu-DPI-4452 [177Lu]Lu-DPI-4452 Phase 2 Clinical Debiopharm International Sa Carcinoma, Renal Cell; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal Details
PHC-102 PHC102; 99mTc-CAIX Phase 1 Clinical Philochem Carcinoma, Renal Cell Details
Indium-111-DOTA-girentuximab-IRDye800CW (Radboud University) Phase 1 Clinical Radboud University Nijmegen Carcinoma, Renal Cell; Diagnostic agents Details
Girentuximab-Zr-89 TLX-250-CDx; 89Zr-TX-250; TLX250-CDx; 89Zr-TX250 Phase 3 Clinical Wilex Urinary Bladder Neoplasms; Carcinoma, Hepatocellular; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Nasopharyngeal Carcinoma; Sarcoma; Cholangiocarcinoma; Contrast agents; Solid tumours; Carcinoma, Transitional Cell; Carcinoma, Ovarian Epithelial; Glioblastoma; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Stomach Neoplasms Details
Girentuximab  MAb-G250; cG250; WX-G250 Phase 1 Clinical Wilex Kidney Neoplasms; Carcinoma, Renal Cell Details
Debio-0328 [68Ga]Ga-DPI-4452; Gallium-68-DPI-4452 Phase 2 Clinical Debiopharm International Sa Carcinoma, Renal Cell; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal Details
Sulfamide-nitroimidazole Clinical Dualtpharma Neoplasms Details
PMI-05 PMI-05 Phase 1 Clinical Neoplasms Details
Lutetium-177 DOTA girentuximab TLX-250 Phase 2 Clinical Wilex, Heidelberg, Telix Pharmaceuticals Ltd Solid tumours; Carcinoma, Renal Cell; Neoplasms Details
CA9hu-1 CA9hu-1 Phase 1 Clinical Mabpro AS Head and Neck Neoplasms; Carcinoma, Renal Cell; Triple Negative Breast Neoplasms; Mesothelioma; Carcinoma, Non-Small-Cell Lung Details

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