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TNFR1

Brief Information

Name:Tumor necrosis factor receptor superfamily member 1A
Target Synonym:Tumor necrosis factor receptor 1,TNF-R1,Tumor necrosis factor receptor type I,TNF-RI,TNFR-I,CD120a,TNF Receptor Superfamily Member 1A,TNFAR,Tumor Necrosis Factor Receptor Superfamily Member 1A,TNF-R-I,TNF-R55,TNFR60,TNF-R,TNFR1,Tumor Necrosis Factor Receptor Superfamily, Member 1A,Tumor Necrosis Factor Receptor 1A Isoform Beta,Tumor Necrosis Factor Binding Protein 1,Tumor Necrosis Factor Receptor Type 1,Tumor Necrosis Factor Receptor Type I,Tumor Necrosis Factor-Alpha Receptor,Tumor Necrosis Fac
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 3 Clinical

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Kat. Nr. Arten Produktbeschreibung Struktur Reinheit Merkmal
TN1-H5251 Human Human TNFR1 / CD120a / TNFRSF1A Protein, Fc Tag (MALS verified)
TN1-H5251-structure
TN1-H5251-sds
TN1-H5222 Human Human TNFR1 / CD120a / TNFRSF1A Protein, His Tag
TN1-H5222-structure
TN1-H5222-sds
ACRO Quality

Part of Bioactivity data

TN1-H5222-ELISA
 TNFR1 ELISA

Immobilized Human TNF-alpha, premium grade (Cat. No. TNA-H4211) at 2 μg/mL (100 μL/well) can bind Human TNFR1, His Tag (Cat. No. TN1-H5222) with a linear range of 3-25 ng/mL (QC tested).

TN1-H5251-MALS-HPLC
TNFR1 MALS images

The purity of Human TNFR1, Fc Tag (Cat. No. TN1-H5251) is more than 85% and the molecular weight of this protein is around 100-122 kDa verified by SEC-MALS.

Customer Reviews

Synonym Name

TNFR1,CD120a,TNFRSF1A,FPF,TBP1,TNF-R,TNF-R-I,TNF-R55,TNFAR,TNFR55,TNFR60,p55,p60

Background

Tumor necrosis factor receptor 1 (TNF-R1) is also known as Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), TNFAR, CD antigen CD120a, which belongs to the tumor necrosis factor receptor superfamily. TNF-R1 contains one death domain and four TNFR-Cys repeats. TNF-R1 is the receptor of TNFSF2 / TNF-alpha and homotrimeric TNFSF1 / lymphotoxin - alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNF-R1 contributes to the induction of non - cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Defects in TNFRSF1A are the cause of familial hibernian fever (FHF).

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Atrosab Phase 1 Clinical Celonic Inflammation Details
Ofranergene obadenovec VB-111; GT-111 Phase 3 Clinical Vascular Pharmaceuticals Inc Ovarian Neoplasms; Thyroid Carcinoma, Anaplastic; Neoplasms; Glioblastoma; Neuroendocrine Tumors; Colorectal Neoplasms Details

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