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TNF-beta

Brief Information

Name:Tumor necrosis factor β
Target Synonym:TNF Superfamily Member 1,TNLG1E,LT,Lymphotoxin-alpha,TNFSF1,Tumor Necrosis Factor Ligand Superfamily Member 1,Tumor Necrosis Factor Beta,LT-alpha,LTA#TNFB,LTA,Lymphotoxin Alpha,TNF-Beta,TNFB,Lymphotoxin Alpha (TNF Superfamily, Member 1),Tumor Necrosis Factor Ligand 1E,Truncated Lymphotoxin Alpha,TNF Superfamily, Member 1
Number of Launched Drugs:15
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

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TNB-H52H3 Human Human TNF-beta / Lymphotoxin-alpha Protein, His Tag (MALS verified)
TNB-H52H3-structure
TNB-H52H3-sds
ACRO Quality

Part of Bioactivity data

TNB-H52H3-MALS-HPLC
TNF-beta MALS images

The purity of Human TNF-beta Protein, His Tag (Cat. No. TNB-H52H3) is more than 90% and the molecular weight of this protein is around 62-78 kDa verified by SEC-MALS.

TNB-H52H3-ELISA
 TNF-beta ELISA

Immobilized Human TNFR1, Fc Tag (Cat. No. TN1-H5251) at 5 μg/mL (100 μL/well) can bind Human TNF-beta Protein, His Tag (Cat. No. TNB-H52H3) with a linear range of 1-20 ng/mL (QC tested).

Synonym Name

LTA,DAMA-25N12,13-004,LT,TNFB,TNFSF1,LT-alpha,TNF-beta

Background

TNF-beta is also known as Lymphotoxin-alpha (LT-alpha or LTA), Tumor necrosis factor ligand superfamily member 1 (TNFSF1), which belongs to the tumor necrosis factor family. TNF-beta can form homotrimer with itself or form heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. The homotrimer of TNF-beta is secreted and the heterotrimer is membrane-associated. The homotrimeric form of NF-beta binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Etanercept biosimilar (Hanwha Chemical) HD-203; MK-8953 Approved Hanwha Chemical Davictrel Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic Details
Etanercept biosimilar (AryoGen Biopharma) Approved Aryogen Biopharma Altebrel Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic Details
Etanercept biosimilar (Nanogen Biopharmaceutical) Approved Nanogen Biopharmaceutical Co Nanercept Vietnam Arthritis, Rheumatoid; Psoriasis Nanogen Biopharmaceutical Co 2019-01-01 Arthritis, Rheumatoid; Psoriasis Details
Etanercept biosimilar (Mochida) LBEC-0101 Approved Mochida Pharmaceutical Co Ltd Japan Arthritis, Juvenile; Arthritis, Rheumatoid null 2018-01-19 Arthritis, Rheumatoid; Arthritis, Juvenile Details
Etanercept biosimilar (PROBIOMED) Approved Probiomed Infinitam Mexico Arthritis, Rheumatoid Probiomed 2014-01-01 Arthritis, Rheumatoid Details
Etanercept biosimial (Sandoz) GP-2015 Approved Clariant Produkte (Schweiz) Ag Erelzi United States Psoriasis; Arthritis, Rheumatoid; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile Sandoz 2016-08-30 Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Plaque psoriasis Details
Etanercept biosimilar (Amega Biotech) Approved Amega Biotech Enerceptan Argentina Arthritis, Rheumatoid Amega Biotech 2012-01-01 Arthritis, Rheumatoid Details
Etanercept biosimilar (Intas Biopharmaceuticals) Approved Intas Biopharmaceuticals Intacept India Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Psoriasis Intas Biopharmaceuticals 2015-03-01 Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic Details
Etanercept biosimilar (Mylan) YLB-113 Approved Lupin Ltd, Mylan Nv Nepexto EU Plaque psoriasis; Arthritis, Juvenile; Arthritis, Rheumatoid; Spondylarthropathies; Spondylitis, Ankylosing; Arthritis, Psoriatic Biosimilar Collaborations Ireland Ltd 2020-05-20 Arthritis, Rheumatoid; Spondylarthropathies; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Psoriatic; Plaque psoriasis Details
Etanercept biosimilar (Sunshine Guojian) 301S Approved Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd, Cipla Gmbh Yisaipu, 益赛普, Etanar, Etacept Mainland China Arthritis, Rheumatoid; Psoriasis; Spondylitis, Ankylosing Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd 2005-06-20 Non-radiographic axial spondyloarthritis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis Details
Opinercept E-11; ENIA-11 Approved Tsh Biopharm, Mycenax Biotech Inc TuNEX Taiwan Arthritis, Rheumatoid null 2017-01-01 Non-radiographic axial spondyloarthritis; Arthritis, Rheumatoid Details
Etanercept biosimilar (Hisun-Pfizer Pharmaceuticals) Approved Hisun-Pfizer AnBaiNuo Mainland China Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic Wyeth Europa Ltd 2010-02-26 Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic Details
Etanercept biosimilar (Qilu Pharmaceutical) QL-0902 Approved Qilu Pharmaceutical Co Ltd Mainland China Qilu Pharmaceutical Co Ltd 2023-12-19 Arthritis, Rheumatoid; Spondylitis, Ankylosing Details
Etanercept biosimilar (Samsung Bioepis) SB-4 Approved Samsung Bioepis Co Ltd Eticovo, Benepali EU Arthritis, Psoriatic; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Plaque psoriasis Samsung Bioepis Nl Bv 2016-01-13 Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Plaque psoriasis Details
Etanercept TNR-001 Approved Amgen Inc, Pfizer Inc Lifmior, 恩利, Enbrel EU Plaque psoriasis; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Psoriatic; Arthritis, Juvenile Pfizer Europe Ma Eeig 2000-02-02 Obesity; Pulmonary Fibrosis; Psoriasis; Myositis, Inclusion Body; Prostatic Neoplasms; Temporomandibular Joint Disorders; Arthritis, Psoriatic; Bone Neoplasms; Lichen Planus; Alzheimer Disease; Asthma; Hidradenitis Suppurativa; Respiratory Distress Syndrome, Adult; Inflammation; Cachexia; Arthritis; Lung Neoplasms; Uveitis; Plaque psoriasis; Vitiligo; Neoplasm Metastasis; Acute Lung Injury; Kidney Failure, Chronic; Stomatitis; Spondylitis, Ankylosing; Granulomatosis with Polyangiitis; Leukemia; Non-radiographic axial spondyloarthritis; Bronchiolitis Obliterans; Solid tumours; Tinnitus; HIV Infections; Lupus Erythematosus, Discoid; Rejection of lung transplantation; Arthritis, Rheumatoid; Fanconi Anemia; Diabetes Mellitus, Type 1; Vasculitis; Graft vs Host Disease; Lupus Erythematosus, Cutaneous; Synovitis; Sjogren's Syndrome; Anorexia; Metabolic Syndrome; Spondylarthritis; Chronic Urticaria; Small Cell Lung Carcinoma; Arthritis, Juvenile Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Etanercept biosimilar (Suzhou Genemen Biotech) BF-02; GM-02 Phase 1 Clinical Suzhou Genemen Biotech Co Ltd Spondylitis, Ankylosing Details
Etanercept (Neurokine Pharmaceuticals) NP-1; NK-001 Clinical Pivot Pharmaceuticals Cognition Disorders Details

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