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Your Position: Start > NKp46

NKp46

Brief Information

Name:Natural cytotoxicity triggering receptor 1
Target Synonym:NK cell-activating receptor,NK-p46,Lymphocyte antigen 94 homolog,NKp46,hNKp46,Lymphocyte Antigen 94 Homolog (Activating NK-Receptor; NK-P46),Natural killer cell p46-related protein,LY94,Lymphocyte Antigen 94 (Mouse) Homolog (Activating NK-Receptor; NK-P46),CD335 Antigen,CD335
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 2 Clinical

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CHEK-ATP153 Human HEK293/Human NKp46 Stable Cell Line
NC1-H5259 Human Human NKp46 / NCR1 / CD335 Protein, Fc Tag
NC1-H5259-structure
NC1-H5258 Human Human NKp46 / NCR1 / CD335 Protein, Fc Tag
NC1-H5258-structure
NC1-H5258-sds
NC1-M5259 Mouse Mouse NKp46 / NCR1 / CD335 Protein, Fc Tag (MALS verified)
NC1-M5259-structure
NC1-M5259-sds
CEA-B040 Human ClinMax™ Human NKp46/NCR1 ELISA Kit, PRO
NP6-H82H3 Human Biotinylated Human NKp46 Protein, His,Avitag™, premium grade
NP6-H82H3-structure
NP6-H82H3-sds
NC1-M52H7 Mouse Mouse NKp46 / NCR1 / CD335 Protein, His Tag
NC1-M52H7-structure
NC1-M52H7-sds
NC1-H52H6 Human Human NKp46 / NCR1 / CD335 Protein, His Tag
NC1-H52H6-structure
NC1-H52H6-sds
NK6-H82E2 Human Biotinylated Human NKp46 / CD335 Protein, His Tag, ultra sensitivity (primary amine labeling)
NK6-H82E2-structure
NK6-H82E2-sds
NC1-M82H5 Mouse Biotinylated Mouse NKp46 / NCR1 / CD335 Protein, His,Avitag™
NC1-M82H5-structure
NC1-M82H5-sds
NC1-C5255 Cynomolgus Cynomolgus NKp46 / NCR1 / CD335 Protein, Llama IgG2b Fc Tag, low endotoxin
NC1-C5255-structure
NC1-C5255-sds
NC1-C82E5 Cynomolgus Biotinylated Cynomolgus NKp46 / NCR1 / CD335 Protein, His,Avitag™ (MALS verified)
NC1-C82E5-structure
NC1-C82E5-sds
NC1-C52H4 Cynomolgus Cynomolgus NKp46 / NCR1 / CD335 Protein, His Tag (MALS verified)
NC1-C52H4-structure
NC1-C52H4-sds
NC1-H82F9 Human Biotinylated Human NKp46 / NCR1 / CD335 Protein, Fc,Avitag™, premium grade
NC1-H82F9-structure
NC1-H82F9-sds
NC1-H5255 Human Human NKp46 / NCR1 / CD335 Protein, Llama IgG2b Fc Tag, low endotoxin
NC1-H5255-structure
NC1-H5255-sds
NC1-H52H4 Human Human NKp46 / NCR1 / CD335 Protein, His Tag (MALS verified)
NC1-H52H4-structure
NC1-H52H4-sds
NC1-H5257 Human Human NKp46 / NCR1 / CD335 Protein, Fc Tag, premium grade
NC1-H5257-structure
NC1-H5257-sds
ACRO Quality

Synonym Name

NCR1,LY94,CD335,NK-p46,NKp46,hNKp46,NCR-1,LY-94

Background

Natural cytotoxicity triggering receptor 1 (NCR1) is also known as Natural killer cell p46-related protein (NK-p46), Lymphocyte antigen 94 homolog (LY94), CD antigen CD335, which belongs to the natural cytotoxicity receptor (NCR) family. NCR1 contains two Ig-like (immunoglobulin-like) domains. NCR1 interacts with CD247 and FCER1G. NCR1 / CD335 may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
IPH-6501 IPH-6501; IPH-65 Phase 2 Clinical Innate Pharma SA Neoplasms; Lymphoma, Non-Hodgkin Details
SAR445514 SAR445514; SAR-445514; IPH6401/SAR514 Phase 2 Clinical Sanofi Immunoglobulin Light-chain Amyloidosis; Multiple Myeloma Details
SAR-443579 SAR-443579; SAR443579; SAR579; IPH6101; IPH-6101 Phase 2 Clinical Sanofi Hematologic Diseases; Myelodysplastic Syndromes; Blastic Plasmacytoid Dendritic Cell Neoplasm; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, B-Cell; Leukemia, Myeloid, Acute Details
IPH-6501 IPH-6501; IPH-65 Phase 2 Clinical Innate Pharma SA Neoplasms; Lymphoma, Non-Hodgkin Details
SAR445514 SAR445514; SAR-445514; IPH6401/SAR514 Phase 2 Clinical Sanofi Immunoglobulin Light-chain Amyloidosis; Multiple Myeloma Details
SAR-443579 SAR-443579; SAR443579; SAR579; IPH6101; IPH-6101 Phase 2 Clinical Sanofi Hematologic Diseases; Myelodysplastic Syndromes; Blastic Plasmacytoid Dendritic Cell Neoplasm; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, B-Cell; Leukemia, Myeloid, Acute Details

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