0
Es befinden sich keine Waren im Warenkorb !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Start > Osteoactivin

Osteoactivin

Brief Information

Name:Transmembrane glycoprotein NMB
Target Synonym:Transmembrane Glycoprotein,HGFIN,Transmembrane glycoprotein NMB,Hematopoietic growth factor inducible neurokinin-1 type,GPNMB,Glycoprotein Nmb,Hematopoietic Growth Factor Inducible Neurokinin-1,Glycoprotein Nonmetastatic Melanoma Protein B,Transmembrane Glycoprotein HGFIN,Glycoprotein (Transmembrane) Nmb,Glycoprotein Nmb-Like Protein,Osteoactivin,PLCA3,NMB,UNQ1725/PRO9925
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

Product ListCompare or Buy

Nach Produktstatus:
Nach Produktkategorie :
Nach Arten:
Nach Markierungen:
Nach Konjugaten:
Kat. Nr. Arten Produktbeschreibung Struktur Reinheit Merkmal
GPB-H5229 Human Human Osteoactivin / GPNMB Protein, His Tag
GPB-H5229-structure
GPB-H5229-sds
ACRO Quality

Synonym Name

GPNMB,HGFIN,NMB,Osteoactivin

Background

Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Glembatumumab vedotin CR-011; CDX-011; CR-011-ADC; CR011-vcMMAE Phase 2 Clinical Celldex Therapeutics Solid tumours; Triple Negative Breast Neoplasms; Breast Neoplasms; Osteosarcoma; Carcinoma, Squamous Cell; Melanoma Details

This web search service is supported by Google Inc.

totop
Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
Fax
Fax
+1 888-377-6111
Address
Address
Lichtstrasse 35,4056 Basel, Switzerland

Nachricht schicken