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Your Position: Start > Osteoactivin

Osteoactivin

Brief Information

Name:Transmembrane glycoprotein NMB
Target Synonym:Transmembrane Glycoprotein,HGFIN,Transmembrane glycoprotein NMB,Hematopoietic growth factor inducible neurokinin-1 type,GPNMB,Glycoprotein Nmb,Hematopoietic Growth Factor Inducible Neurokinin-1,Glycoprotein Nonmetastatic Melanoma Protein B,Transmembrane Glycoprotein HGFIN,Glycoprotein (Transmembrane) Nmb,Glycoprotein Nmb-Like Protein,Osteoactivin,PLCA3,NMB,UNQ1725/PRO9925
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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GPB-H5229 Human Human Osteoactivin / GPNMB Protein, His Tag
GPB-H5229-structure
GPB-H5229-sds
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Synonym Name

GPNMB,HGFIN,NMB,Osteoactivin

Background

Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Glembatumumab vedotin CR-011; CDX-011; CR-011-ADC; CR011-vcMMAE Phase 2 Clinical Celldex Therapeutics Solid tumours; Triple Negative Breast Neoplasms; Osteosarcoma; Breast Neoplasms; Carcinoma, Squamous Cell; Melanoma Details
Glembatumumab vedotin CR-011; CDX-011; CR-011-ADC; CR011-vcMMAE Phase 2 Clinical Celldex Therapeutics Solid tumours; Triple Negative Breast Neoplasms; Osteosarcoma; Breast Neoplasms; Carcinoma, Squamous Cell; Melanoma Details

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