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Your Position: Start > EpCAM

EpCAM

Brief Information

Name:Epithelial cell adhesion molecule
Target Synonym:Epithelial Cell Adhesion Molecule,Tumor-Associated Calcium Signal Transducer 1,Major Gastrointestinal Tumor-Associated Protein GA733-2,Cell Surface Glycoprotein Trop-1,Epithelial Glycoprotein 314,TROP1,KSA,Membrane Component, Chromosome 4, Surface Marker (35kD Glycoprotein),Antigen Identified By Monoclonal Antibody AUA1,Human Epithelial Glycoprotein-2,Epithelial Cell Surface Antigen,CD326 Antigen,HEGP314,HNPCC8,Ep-CAM,DIAR5,EGP-2,EGP40,KS1/4,MK-1,M1S2,ESA,Ly74,TACST-1,CO-17A,17-1A,EGP34,HEA125,M
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:10
Lastest Research Phase:Phase 3 Clinical

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
EpCAM CAR-T -01 IIT Solid Tumor Gastric Cancer

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CHEK-ATP175 Human HEK293/Human EpCAM Stable Cell Line
EPM-R82E3 Rhesus macaque Biotinylated Rhesus macaque EpCAM / TROP1 Protein, His,Avitag™ (MALS verified)
EPM-R82E3-structure
EPM-R82E3-sds
EPM-H5259 Human Human EpCAM / TROP1 Protein, Llama IgG2b Fc Tag, low endotoxin
EPM-H5259-structure
EPM-H5259-sds
EPM-H5255 Human Human EpCAM / TROP1 Protein, Mouse IgG2a Fc Tag
EPM-H5255-structure
EPM-H5255-sds
EPM-HF255 Human FITC-Labeled Human EpCAM / TROP1 Protein, Fc Tag
EPM-HF255-structure
EPM-HF255-sds
EPM-HF225 Human FITC-Labeled Human EpCAM / TROP1 Protein, His Tag
EPM-HF225-structure
EPM-HF225-sds
EPM-H82F9 Human Biotinylated Human EpCAM / TROP1 Protein, Fc,Avitag™ (MALS verified)
EPM-H82F9-structure
EPM-H82F9-sds
EPM-H82E8 Human Biotinylated Human EpCAM / TROP1 Protein, Avitag™,His Tag (MALS verified)
EPM-H82E8-structure
EPM-H82E8-sds
EPM-C5227 Rhesus macaque Rhesus macaque EpCAM / TROP1 Protein, His Tag
EPM-C5227-structure
EPM-C5227-sds
EPM-M5227 Mouse Mouse EpCAM / TROP1 Protein, His Tag (MALS verified)
EPM-M5227-structure
EPM-M5227-sds
EPM-H5223 Human Human EpCAM / TROP1 Protein, His Tag
EPM-H5223-structure
EPM-H5223-sds
EPM-H5254 Human Human EpCAM / TROP1 Protein, Fc Tag
EPM-H5254-structure
EPM-H5254-sds
ACRO Quality

Part of Bioactivity data

CHEK-ATP175-Cell-based assay
EpCAM FACS

Expression analysis of human EpCAM on HEK293/Human EpCAM Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human EpCAM Stable Cell Line or negative control cell using PE-labeled anti-human EpCAM antibody.

Protocol
EPM-H5259-ELISA
EpCAM ELISA

Immobilized Human EpCAM, Llama IgG2b Fc Tag (Cat. No. EPM-H5259) at 1 μg/mL (100 μL/well) can bind Anti-EpCAM Antibody, Human IgG1 with a linear range of 0.2-8 ng/mL (QC tested).

Protocol
EPM-R82E3-MALS-HPLC
EpCAM MALS images

The purity of Biotinylated Rhesus macaque EpCAM / TROP1 Protein, His,Avitag (Cat. No. EPM-R82E3) is more than 90% and the molecular weight of this protein is around 28-40 kDa verified by SEC-MALS.

Customer Reviews

Synonym Name

EPCAM,TACSTD1,TROP1,CD326,DIAR5,EGP2,EGP314,EGP40,ESA,GA733-2,HNPCC8,HNPCC-8,KS1,4,KSA,M4S1,MIC18,MK1

Background

EpCAM is also known as CO171A, EGP, EGP40,GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy.Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
M-701 M-701 Phase 3 Clinical Wuhan Yzy Biopharma Co Ltd Ovarian Neoplasms; Solid tumours; Hydrothorax; Stomach Neoplasms; Neoplasms; Ascites; Colorectal Neoplasms; Pleural Effusion, Malignant; Carcinoma, Non-Small-Cell Lung Details
Oportuzumab monatox 4D5MOCB-ETA; VB4-845; VB-4847; B-4845; VB-845 Phase 3 Clinical Viventia Biotech Inc, Sesen Bio Inc Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck; Neoplasms, Squamous Cell; Urinary Bladder Neoplasms; Carcinoma, Squamous Cell; Mouth Neoplasms Details
Catumaxomab LP000 Phase 3 Clinical Trion Research, Neovii Biotech Gmbh Ovarian Neoplasms; Stomach Neoplasms; Carcinoma; Neoplasms; Carcinoma, Ovarian Epithelial; Colonic Neoplasms; Urinary Bladder Neoplasms; Ascites; Breast Neoplasms Details
Anti-EPCAM CAR-T cell therapy (Sinobioway) Phase 2 Clinical Beijing Sinobioway Bioengineering Group Co Ltd Liver Neoplasms; Stomach Neoplasms Details
DuoBody-EpCAMx4-1BB BNT314/GEN1059; GEN-1059; GEN1059; BNT314 Phase 2 Clinical Biontech Se, Genmab A/S Solid tumours; Neoplasms Details
IMC-001(Immunofoco) IMC001; IMC-001 Phase 2 Clinical Suzhou Immunofoco Biotechnology Co Ltd Solid tumours; Stomach Neoplasms; Esophageal Neoplasms; Pancreatic Neoplasms; Digestive System Neoplasms; Colorectal Neoplasms; Carcinoma, Hepatocellular; Gastrointestinal Neoplasms Details
BA-3182 BA-3182 Phase 1 Clinical Bioatla Solid tumours; Adenocarcinoma Details
AM-928 AM-928 Phase 1 Clinical AcadeMab Biomedical Inc Solid tumours; Head and Neck Neoplasms; Thyroid Carcinoma, Anaplastic; Colorectal Neoplasms Details
CX-2051 CX-2051 Phase 1 Clinical Immunogen Inc, Cytomx Therapeutics Inc Solid tumours; Neoplasms; Colorectal Neoplasms Details
A-337 A-337 Phase 1 Clinical Evive Biotech Ltd Solid tumours; Neoplasms Details

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