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| Kat. Nr. | Arten | Produktbeschreibung | Struktur | Reinheit | Merkmal |
|---|---|---|---|---|---|
| EDA-H52P8 | Human | Human EDNRA Full Length Protein (VLP) |
| Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
|---|---|---|---|---|---|---|---|---|---|---|
| Clazosentan Sodium | Ro-61-1790; ACT-108475; AXV-034; VML-588; AXV-034343 | Approved | F. Hoffmann-La Roche Ltd | Pivlaz | Japan | Subarachnoid Hemorrhage; Vasospasm, Intracranial; Cerebral Infarction; Brain Ischemia | Idorsia Pharmaceuticals Ltd | 2022-01-20 | Brain Ischemia; Aneurysm; Vasospasm, Intracranial; Subarachnoid Hemorrhage; Cerebral Infarction | Details |
| Macitentan/Tadalafil | Approved | Actelion Pharmaceuticals Ltd | OPSYNVI | United States | Pulmonary Arterial Hypertension | Actelion Pharmaceuticals Us Inc | 2024-03-22 | Pulmonary Arterial Hypertension | Details | |
| Ambrisentan | LU-208075; BSF-208075; GSK-132576A | Approved | Abbott Laboratories | Letairis, Volibris, 凡瑞克 | United States | Pulmonary Arterial Hypertension | Gilead Sciences Inc | 2007-06-15 | Acute Kidney Injury; Anemia, Sickle Cell; Hepatorenal Syndrome; Vascular Diseases; Pulmonary Arterial Hypertension; Thromboembolism; Hypertension; Hypoxia; Ascites; Hypertension, Pulmonary; Sarcoidosis; Scleroderma, Systemic; Hypertension, Portal; Idiopathic Pulmonary Fibrosis; Fibrosis; Coronavirus Disease 2019 (COVID-19); Liver Cirrhosis | Details |
| Sparsentan | RE-021; PS-433540; BMS-346567 | Approved | Bristol-Myers Squibb Company | Filspari | United States | Glomerulonephritis, IGA | Travere Therapeutics Inc | 2023-02-17 | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Glomerulonephritis, IGA; Kidney Diseases; Vasculitis; Autoimmune Diseases; Nephrosis, Lipoid; Hypertension; Immune System Diseases; Glomerulosclerosis, Focal Segmental; Cardiovascular Diseases; Nephritis, Hereditary; Glomerulonephritis | Details |
| Bosentan Hydrate | ACT-050088; HGP-1206; Ro-47-0203; Ro-47-0203/029; Ro-47-0203/039 | Approved | F. Hoffmann-La Roche Ltd | Stayveer, 全可利, Tracleer | United States | Pulmonary Arterial Hypertension | Actelion Pharmaceuticals Ltd | 2001-11-20 | Pulmonary Fibrosis; Heart Defects, Congenital; Diabetes Mellitus; Anemia, Sickle Cell; Persistent Fetal Circulation Syndrome; Ulcer; Sleep Apnea Syndromes; Glaucoma; Pulmonary Arterial Hypertension; Hypertension; Hepatopulmonary Syndrome; Hypertension, Pulmonary; Lung Diseases, Interstitial; Sarcoidosis; Liver Cirrhosis; Chronic thromboembolic pulmonary hypertension; Fibrosis; Scleroderma, Systemic; Idiopathic Pulmonary Fibrosis; Diabetes Mellitus, Type 2; Heart Septal Defects, Atrial | Details |
| Macitentan | ACT-064992; Actelion-1; JNJ-67896062 | Approved | Actelion Pharmaceuticals Ltd | Zependo, Opsumit, 傲朴舒 | United States | Pulmonary Arterial Hypertension | Actelion Pharmaceuticals Us Inc | 2013-10-18 | Hypertension, Pulmonary; Pulmonary Embolism; Heart Failure; Idiopathic Pulmonary Fibrosis; Scleroderma, Systemic; Chronic thromboembolic pulmonary hypertension; Glioblastoma; Lung Diseases, Interstitial; Thromboembolism; Pulmonary Arterial Hypertension; Eisenmenger Complex; Ulcer; Anemia, Sickle Cell; Chronic Disease; Heart Defects, Congenital | Details |
| Aprocitentan | ACT-132577; AC-080; JNJ-2820 | Approved | Idorsia Pharmaceuticals Ltd, Actelion Pharmaceuticals Ltd | TRYVIO | United States | Hypertension | Idorsia Pharmaceuticals Ltd | 2024-03-19 | Hypertension; Hepatic Insufficiency; Essential Hypertension; Renal Insufficiency, Chronic | Details |
| Clazosentan Sodium | Ro-61-1790; ACT-108475; AXV-034; VML-588; AXV-034343 | Approved | F. Hoffmann-La Roche Ltd | Pivlaz | Japan | Subarachnoid Hemorrhage; Vasospasm, Intracranial; Cerebral Infarction; Brain Ischemia | Idorsia Pharmaceuticals Ltd | 2022-01-20 | Brain Ischemia; Aneurysm; Vasospasm, Intracranial; Subarachnoid Hemorrhage; Cerebral Infarction | Details |
| Macitentan/Tadalafil | Approved | Actelion Pharmaceuticals Ltd | OPSYNVI | United States | Pulmonary Arterial Hypertension | Actelion Pharmaceuticals Us Inc | 2024-03-22 | Pulmonary Arterial Hypertension | Details | |
| Ambrisentan | LU-208075; BSF-208075; GSK-132576A | Approved | Abbott Laboratories | Letairis, Volibris, 凡瑞克 | United States | Pulmonary Arterial Hypertension | Gilead Sciences Inc | 2007-06-15 | Acute Kidney Injury; Anemia, Sickle Cell; Hepatorenal Syndrome; Vascular Diseases; Pulmonary Arterial Hypertension; Thromboembolism; Hypertension; Hypoxia; Ascites; Hypertension, Pulmonary; Sarcoidosis; Scleroderma, Systemic; Hypertension, Portal; Idiopathic Pulmonary Fibrosis; Fibrosis; Coronavirus Disease 2019 (COVID-19); Liver Cirrhosis | Details |
| Sparsentan | RE-021; PS-433540; BMS-346567 | Approved | Bristol-Myers Squibb Company | Filspari | United States | Glomerulonephritis, IGA | Travere Therapeutics Inc | 2023-02-17 | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Glomerulonephritis, IGA; Kidney Diseases; Vasculitis; Autoimmune Diseases; Nephrosis, Lipoid; Hypertension; Immune System Diseases; Glomerulosclerosis, Focal Segmental; Cardiovascular Diseases; Nephritis, Hereditary; Glomerulonephritis | Details |
| Bosentan Hydrate | ACT-050088; HGP-1206; Ro-47-0203; Ro-47-0203/029; Ro-47-0203/039 | Approved | F. Hoffmann-La Roche Ltd | Stayveer, 全可利, Tracleer | United States | Pulmonary Arterial Hypertension | Actelion Pharmaceuticals Ltd | 2001-11-20 | Pulmonary Fibrosis; Heart Defects, Congenital; Diabetes Mellitus; Anemia, Sickle Cell; Persistent Fetal Circulation Syndrome; Ulcer; Sleep Apnea Syndromes; Glaucoma; Pulmonary Arterial Hypertension; Hypertension; Hepatopulmonary Syndrome; Hypertension, Pulmonary; Lung Diseases, Interstitial; Sarcoidosis; Liver Cirrhosis; Chronic thromboembolic pulmonary hypertension; Fibrosis; Scleroderma, Systemic; Idiopathic Pulmonary Fibrosis; Diabetes Mellitus, Type 2; Heart Septal Defects, Atrial | Details |
| Macitentan | ACT-064992; Actelion-1; JNJ-67896062 | Approved | Actelion Pharmaceuticals Ltd | Zependo, Opsumit, 傲朴舒 | United States | Pulmonary Arterial Hypertension | Actelion Pharmaceuticals Us Inc | 2013-10-18 | Hypertension, Pulmonary; Pulmonary Embolism; Heart Failure; Idiopathic Pulmonary Fibrosis; Scleroderma, Systemic; Chronic thromboembolic pulmonary hypertension; Glioblastoma; Lung Diseases, Interstitial; Thromboembolism; Pulmonary Arterial Hypertension; Eisenmenger Complex; Ulcer; Anemia, Sickle Cell; Chronic Disease; Heart Defects, Congenital | Details |
| Aprocitentan | ACT-132577; AC-080; JNJ-2820 | Approved | Idorsia Pharmaceuticals Ltd, Actelion Pharmaceuticals Ltd | TRYVIO | United States | Hypertension | Idorsia Pharmaceuticals Ltd | 2024-03-19 | Hypertension; Hepatic Insufficiency; Essential Hypertension; Renal Insufficiency, Chronic | Details |
| Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
|---|---|---|---|---|---|
| Zibotentan/Dapagliflozin | Phase 3 Clinical | Astrazeneca Ab, AstraZeneca global R & D (China) Co Ltd | Albuminuria; Kidney Diseases; Renal Insufficiency, Chronic | Details | |
| Atrasentan | ABT-627; A-147627; A-1476271; ABT-147627; (+)-A-127722; Abbott-147627 | Phase 3 Clinical | Abbvie Inc | Kidney Neoplasms; Ovarian Neoplasms; Glomerulonephritis, IGA; Abdominal Neoplasms; Kidney Diseases; Central Nervous System Neoplasms; Brain Neoplasms; Glomerulosclerosis, Focal Segmental; Prostatic Neoplasms; Diabetic Nephropathies; Renal Insufficiency, Chronic; Fallopian Tube Neoplasms; Adenocarcinoma; Nephritis, Hereditary; Neoplasm Metastasis; Diabetes Mellitus | Details |
| Patecibart | GMA-301; GMA-301-A; GMA-301-B | Phase 2 Clinical | Gmax Biopharm Llc | Pulmonary Arterial Hypertension | Details |
| SC-0062 | SC-0062 | Phase 2 Clinical | Shijiazhuang Zhikang Hongren New Drug Development Co Ltd | Glomerulonephritis, IGA; Altitude Sickness; Kidney Diseases; Pulmonary Arterial Hypertension; Diabetic Nephropathies | Details |
| Zibotentan | ZD-4054; AZD-4054 | Phase 2 Clinical | Astrazeneca Plc | Prostatic Neoplasms; Neoplasm Metastasis; Scleroderma, Limited; Carcinoma, Non-Small-Cell Lung; Peripheral Arterial Disease; Lung Neoplasms; Renal Insufficiency, Chronic; Hepatic Insufficiency; Colorectal Neoplasms; Breast Neoplasms; Ovarian Neoplasms; Kidney Diseases; Hypertension, Portal; Small Cell Lung Carcinoma; Scleroderma, Systemic; Liver Cirrhosis; Intermittent Claudication; Solid tumours; Microvascular Angina | Details |
| BQ-123 | CGS-26343; BQ-123; PMZ-2123 | Phase 1 Clinical | Midwestern University | Hypertension, Pulmonary; Heart Failure; ST Elevation Myocardial Infarction; Pain; Diabetic Ketoacidosis; Coronary Artery Disease; Proteinuria; Metabolic Syndrome; Hypoxia, Brain; Hypertension; Cardiovascular Diseases; Renal Insufficiency, Chronic; Multiple System Atrophy; Pure Autonomic Failure | Details |
| GMA-131 | GMA-131 | Phase 1 Clinical | Gmax Biopharm Llc, Gmaxx Biologics Ltd | Diabetic Nephropathies | Details |
| SAL-0120 | SAL0120; SAL-0120 | Phase 1 Clinical | Shenzhen Salubris Pharmaceuticals Co Ltd | Glomerulonephritis, IGA; Hypertension; Essential Hypertension | Details |
| Zibotentan/Dapagliflozin | Phase 3 Clinical | Astrazeneca Ab, AstraZeneca global R & D (China) Co Ltd | Albuminuria; Kidney Diseases; Renal Insufficiency, Chronic | Details | |
| Atrasentan | ABT-627; A-147627; A-1476271; ABT-147627; (+)-A-127722; Abbott-147627 | Phase 3 Clinical | Abbvie Inc | Kidney Neoplasms; Ovarian Neoplasms; Glomerulonephritis, IGA; Abdominal Neoplasms; Kidney Diseases; Central Nervous System Neoplasms; Brain Neoplasms; Glomerulosclerosis, Focal Segmental; Prostatic Neoplasms; Diabetic Nephropathies; Renal Insufficiency, Chronic; Fallopian Tube Neoplasms; Adenocarcinoma; Nephritis, Hereditary; Neoplasm Metastasis; Diabetes Mellitus | Details |
| Patecibart | GMA-301; GMA-301-A; GMA-301-B | Phase 2 Clinical | Gmax Biopharm Llc | Pulmonary Arterial Hypertension | Details |
| SC-0062 | SC-0062 | Phase 2 Clinical | Shijiazhuang Zhikang Hongren New Drug Development Co Ltd | Glomerulonephritis, IGA; Altitude Sickness; Kidney Diseases; Pulmonary Arterial Hypertension; Diabetic Nephropathies | Details |
| Zibotentan | ZD-4054; AZD-4054 | Phase 2 Clinical | Astrazeneca Plc | Prostatic Neoplasms; Neoplasm Metastasis; Scleroderma, Limited; Carcinoma, Non-Small-Cell Lung; Peripheral Arterial Disease; Lung Neoplasms; Renal Insufficiency, Chronic; Hepatic Insufficiency; Colorectal Neoplasms; Breast Neoplasms; Ovarian Neoplasms; Kidney Diseases; Hypertension, Portal; Small Cell Lung Carcinoma; Scleroderma, Systemic; Liver Cirrhosis; Intermittent Claudication; Solid tumours; Microvascular Angina | Details |
| BQ-123 | CGS-26343; BQ-123; PMZ-2123 | Phase 1 Clinical | Midwestern University | Hypertension, Pulmonary; Heart Failure; ST Elevation Myocardial Infarction; Pain; Diabetic Ketoacidosis; Coronary Artery Disease; Proteinuria; Metabolic Syndrome; Hypoxia, Brain; Hypertension; Cardiovascular Diseases; Renal Insufficiency, Chronic; Multiple System Atrophy; Pure Autonomic Failure | Details |
| GMA-131 | GMA-131 | Phase 1 Clinical | Gmax Biopharm Llc, Gmaxx Biologics Ltd | Diabetic Nephropathies | Details |
| SAL-0120 | SAL0120; SAL-0120 | Phase 1 Clinical | Shenzhen Salubris Pharmaceuticals Co Ltd | Glomerulonephritis, IGA; Hypertension; Essential Hypertension | Details |
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