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Your Position: Start > ACHE

ACHE

Brief Information

Name:Acetylcholinesterase
Target Synonym:EC:3.1.1.7,EC 3.1.1,Acetylcholinesterase (YT Blood Group),Acetylcholinesterase (Cartwright Blood Group),Yt Blood Group,Apoptosis-Related Acetylcholinesterase,Acetylcholinesterase,EC 3.1.1.7,ARACHE,N-ACHE,ACEE,AChE,YT
Number of Launched Drugs:26
Number of Drugs in Clinical Trials:22
Lastest Research Phase:Approved

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AHE-H52H3 Human Human ACHE / Acetylcholinesterase Protein, His Tag (active enzyme)
AHE-H52H3-structure
AHE-H52H3-sds
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Synonym Name

acetylcholinesterase (Yt blood group); Acetylcholinesterase; ACHE; apoptosis-related acetylcholinesterase; ARACHE; EC 3.1.1; EC 3.1.1.7; N-ACHE; Yt blood group; YT

Background

The enzyme acetylcholinesterase, also known as AChE or acetylhydrolase, is the primary cholinesterase in the body. It is a serine hydrolase whose primary function is to catalyzes the breakdown of acetylcholine(ACh) and of some other choline esters that function as neurotransmitters. AChE is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate synaptic transmission.  Acetylcholine deficit has been found in Alzheimer's disease (AD) ans is associated with cognetive decline. Therefore, AChE has been reported to be a viable therapeutic target for the treatment of AD and other dementias. To this end, acetylcholinesterase inhibitors (AChEIs) are commonly used.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Dihydrogalanthamine Hydrobromide Approved Mainland China Hemiplegia; Sciatica null 1982-01-01 Hemiplegia; Sciatica Details
Eserine Salicylate Approved Synapton SR, Xalieve, Antilirium Insulin Resistance; Pain, Postoperative; Psychotic Disorders; Glaucoma Details
Atropine/Pralidoxime Chloride Approved Meridian Medical Technologies Inc DUODOTE United States Poisoning; Organophosphate Poisoning Meridian Medical Technologies LLC 2002-01-17 Drug-Related Side Effects and Adverse Reactions; Organophosphate Poisoning; Poisoning; Drug intoxications Details
Memantine Hydrochloride/Donepezil Hydrochloride ADS-8704; D-797/D-324; CKD 355; BPS-034; BPDO-1603; MDX-8704 Approved Allergan Plc Arimenda, Namzaric United States Alzheimer Disease Abbvie Inc 2014-12-23 Alzheimer Disease Details
Neostigmine methylsulfate Approved Bloxiverz, Intrastigmina, Juvastigmin, Stiglyn, Metastigmin Japan Myasthenia Gravis; Muscle Hypotonia kyowayakuhin Co 1936-10-01 Myasthenia Gravis; Flatulence; Urinary Retention; Reversal of Neuromuscular Blockade; Muscle Hypotonia Details
Huperzine A SPN-817 Approved Chinese Academy Of Sciences, Mayo Clinic 哈伯因, 双益平 Mainland China Alzheimer Disease Henan Taloph Pharmaceutical Stock Co Ltd 1994-01-01 Schizophrenia; Brain Injuries, Traumatic; Seizures; Alzheimer Disease; Epilepsy; Learning Disabilities; Memory Disorders Details
Securinine Nitrate Approved Poliomyelitis; Facial Paralysis Details
Galantamine Hydrobromide GP-37267; R-113675 Approved AverTox, Nivalin, Reminyl, Razadyne, Reminyl XL Mainland China Alzheimer Disease null 1981-01-01 Dementia; Mental Disorders; Fasting; Subarachnoid Hemorrhage; Frontotemporal Dementia; Stress Disorders, Traumatic, Acute; Dementia, Vascular; Cognition Disorders; Cocaine-Related Disorders; Obesity; Nervous System Diseases; Lewy Body Disease; Schizophrenia; Alzheimer Disease; Cognitive Dysfunction; Tobacco Use Disorder; AIDS Dementia Complex; Vascular Diseases; Memory; Autistic Disorder; Stroke; Insulin Resistance; Brain Diseases Details
Pralidoxime Chloride/Benactyzine Hydrochloride/Atropine Sulfate Approved Poisoning Details
Donepezil Hydrochloride DKF-310; BNAG; E-2020; E-2022; (±)-E-2020; IVL-3003; GB-5001 Approved Eisai Co Ltd ADLARITY, Aricept Evess, 安理申, Aricept, Aricept ODT, Aricept D, Memac, Eranz, Memorit United States Alzheimer Disease Eisai Inc 1996-11-25 Parkinson Disease; Autistic Disorder; Radiation Injuries; Aphasia; Hearing Loss, Sensorineural; Brain Neoplasms; Psychology; Fragile X Syndrome; Breast Neoplasms; Alcoholism; Alzheimer Disease; Central Nervous System Neoplasms; Cognitive Dysfunction; Dementia; Lewy Body Disease; Wounds and Injuries; Neoplasm Metastasis; Cognition Disorders; Dementia, Vascular; Memory Disorders; Subarachnoid Hemorrhage; Diabetes Mellitus, Type 2; Drug-Related Side Effects and Adverse Reactions; Supranuclear Palsy, Progressive; Migraine Disorders; Brain Ischemia; Attention; Osteoporosis; Down Syndrome; Depression; Neurologic Manifestations; Autism Spectrum Disorder; Visual Perception; Attention Deficit Disorder with Hyperactivity; Neoplasms; Anxiety Disorders; Sleep Wake Disorders; Fatigue; Smoking Cessation; Delirium; Multiple Sclerosis; Stroke Details
Naphazoline Hydrochloride/Neostigmine methylsulfate Approved Details
Acotiamide Hydrochloride Hydrate Z-338; YM-443 Approved Zeria Acofide Japan Dyspepsia null 2013-03-25 Dyspepsia; Nausea Details
Neostigmine Bromide Approved Prostigmin Mainland China Myasthenia Gravis; Flatulence; Urinary Retention Shanghai Sine Pharmaceutical Laboratories Co Ltd 1995-01-01 Myasthenia Gravis; Headache; Flatulence; Urinary Retention Details
Dextrose/Sodium Chloride/Potassium Chloride/Floxacillin sodium Approved Details
Dextrose/Sodium Chloride/Potassium Chloride/Pralidoxime Chloride Approved Details
Metrifonate Bay-a-9826; Bayer-L-1359 Approved ProMem, Memobay, Bilarcil Schistosomiasis Details
Glycopyrronium bromide/Neostigmine metilsulfate Approved Sintetica Gmbh Novistig Sintetica Gmbh 2020-07-29 Drug Overdose; Muscle Hypotonia; Neuromuscular Diseases; Reversal of Neuromuscular Blockade Details
Rivastigmine Approved Novartis Pharma Ag Parkinson Disease; Alzheimer Disease Details
Pyridostigmine Bromide Ro-1-5130 Approved Valeant Regonol, Mestinon United States Lambert-Eaton Myasthenic Syndrome Bausch & Lomb (Singapore) Pvi Ltd 1955-04-06 Poisoning; Immunologic Deficiency Syndromes; Hypotension, Orthostatic; Fibromyalgia; Diabetes Mellitus; T-Lymphocytopenia, Idiopathic CD4-Positive; Fatigue Syndrome, Chronic; Parkinson Disease; Glycogen Storage Disease Type II; Dyskinesias; Constipation; Prostatic Neoplasms, Castration-Resistant; Coronavirus Disease 2019 (COVID-19); Postural Orthostatic Tachycardia Syndrome; Lambert-Eaton Myasthenic Syndrome; Heart Failure; Myasthenia Gravis; Primary Dysautonomias; HIV Infections Details
Naphazoline Hydrochloride/Neostigmine methylsulfate/Glycyrrhizinate dipotassium/Chlorphenamine Maleate/Aspartic Acid/Vitamin B6 Approved 新乐敦 Details
Distigmine Bromide BC-51 Approved Torii Pharmaceutical Co Ltd Ubretid Japan Glaucoma; Cystitis; Myasthenia Gravis; Strabismus Torii Pharmaceutical Co Ltd 1967-09-05 Myasthenia Gravis; Cystitis; Glaucoma; Strabismus Details
Pralidoxime Iodide 2-PAMI; NSC-7760; 2-PAM Iodide Approved Japan Poisoning Sumitomo Dainippon 1958-05-01 Poisoning Details
Pralidoxime Chloride 2-PAM-chloride Approved Baxter International Inc Protopam chloride United States Poisoning Baxter Healthcare Corp 1964-03-11 Poisoning Details
Rivastigmine Tartrate SDZ-212-713; SDZ-ENA-713; LY-30410; LY-03011; ONO-2540; ENA-713; LY 03013; ENA-713D; LY30410 Approved Novartis Pharma Ag Exelon TDS, Rivastach, Exelon MR, Prometax, Exelon, 艾斯能 EU Parkinson Disease; Dementia; Alzheimer Disease Novartis Europharm Ltd 1998-05-11 Substance-Related Disorders; Down Syndrome; Brain Injuries, Traumatic; Delirium; Neurobehavioral Manifestations; Alzheimer Disease; Parkinson Disease; Dementia; Cocaine-Related Disorders; Dementia, Vascular; Cognition Disorders Details
Dimebolin hydrochloride BRN-0622478; PF-01913539 Approved Dimebon Russian Federation Rhinitis, Allergic; Dermatitis, Atopic; Hypersensitivity null 1983-01-01 Liver Failure; Huntington Disease; Rhinitis, Allergic; Dementia; Alzheimer Disease; Dermatitis, Atopic; Hypersensitivity Details
Dextrose/Sodium Chloride/Potassium Chloride/Anthralin Approved Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Methanesulfonyl fluoride SNX-001 Phase 1 Clinical Senexta Alzheimer Disease Details
Octahydroaminoacridine succinate 华洋-001 Phase 3 Clinical Changchun Huayang High-Tech Co Ltd, Jiangsu Sheneryang High-Tech Co Ltd Alzheimer Disease Details
Pregnenolone NBI-113 Phase 2 Clinical Neurocrine Biosciences Inc Schizophrenia; Autism Spectrum Disorder; Menopausal symptoms; Depressive Disorder, Major; Autistic Disorder; Alcoholism; Stress Disorders, Post-Traumatic; Cocaine-Related Disorders; Low Back Pain Details
EX-039 EX-039 Phase 2 Clinical Excelsior Corp Alzheimer Disease Details
BR-4001 BNT-002; BR-4001 Phase 3 Clinical Boryung Pharmaceutical Co Ltd Alzheimer Disease Details
Benzgalantamine GLN-1062; ALPHA-1062; ALPHA-1062IN Phase 2 Clinical Galantos Pharma GmbH Brain Injuries, Traumatic; Alzheimer Disease Details
Donepezil Hydrochloride/Mefloquine Hydrochloride THN-201 Phase 1 Clinical Theranexus Cognitive Dysfunction; Alzheimer Disease Details
Huperizine-A (Biscayne Pharmaceuticals) INS-001; BIS-001-ER; XEL-001-HG; XEL-001-HP; Hup-A; BIS-001 Phase 2 Clinical Harvard University Seizures; Epilepsy, Complex Partial Details
AGN-151586 AGN-151586 Phase 3 Clinical Allergan Plc Nasolabial fold wrinkles Details
Galantamine/Metformin RJx-01 Phase 1 Clinical Rejuvenate Biomed NV Muscular Atrophy Details
AD-35 AD-35 Phase 2 Clinical Zhejiang Hisun Pharmaceutical Co Ltd Alzheimer Disease Details
Blarcamesine/Donepezil Hydrochloride Phase 2 Clinical Anavex Life Sciences Corp Alzheimer Disease Details
Mecripyrine Hydrochloride SCR-1693; Y-1A; Y-1 Phase 1 Clinical Jiangsu Simcere Pharmaceutical Co Ltd, Yantai Yene Pharma Co Ltd, NeuroDawn Pharmaceutical Co Ltd Brain Neoplasms; Alzheimer Disease Details
Ondansetron Hydrochloride/Pyridostigmine Bromide GTB-004 Phase 2 Clinical Gt Biopharma Inc Myasthenia Gravis Details
HHT-201 HHT-201 Phase 1 Clinical Zhejiang Huahai Pharmaceutical Co Ltd Hypertension; Alzheimer Disease Details
18F-flubatine 18F-flubatine; norchloro-fluoroepibatidine-[18F]; flubatine-[18F]; Fluorine-18-flubatine Phase 1 Clinical Helmholtz-Zentrum Dresden-Rossendorf Alzheimer Disease Details
Donepezil/Solifenacin CPC-201 Phase 3 Clinical Cipla Inc, Allergan Plc Urologic Diseases; Alzheimer Disease; Dementia Details
Donepezil transdermal patch（Dong-A ST） DA-5207 Phase 1 Clinical Dong-A ST Co Ltd Details
Edrophonium Chloride Phase 1 Clinical Teligent Myasthenia Gravis Details
YIV-906 PHY-906; KD-018 Phase 2 Clinical Phytoceutica Inc Liver Neoplasms; Rectal Neoplasms; Pancreatic Neoplasms; Diarrhea; Hepatitis B; Colorectal Neoplasms; Carcinoma, Hepatocellular Details
Fluoropezil DC-20; DC-511020 Phase 2 Clinical Jiangsu Kanion Pharmaceutical Co Ltd, Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Alzheimer Disease Details

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