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KIR2DL4

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Kat. Nr. Arten Produktbeschreibung Struktur Reinheit Merkmal
KI4-H5255 Human Human KIR2DL4 / CD158d Protein, Fc Tag
KI4-H5255-structure
KI4-H5255-sds
ACRO Quality

Part of Bioactivity data

KI4-H5255-ELISA
 KIR2DL4 ELISA

Immobilized Human HLA-G protein, His Tag (Cat. No. HLG-H51H3) at 5 μg/mL (100 μL/well) can bind Human KIR2DL4, Fc Tag (Cat. No. KI4-H5255) with a linear range of 1-10 ng/mL (Routinely tested).

Synonym Name

CD158d

Background

Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4), which belongs to the immunoglobulin superfamily, is an inhibitory receptor of NK cells. Soluble HLA-G binds to KIR2DL4 in endosomes and activates the pathway of DNA-PKcs (DNA-dependent protein kinase, catalytic subunit)-AKT-NF-κB signals. The stimulation of the ITIM of KIR2DL4 protein brings about the recruitment and activation of non-receptor protein phosphatases Src homology 2 domain-containing tyrosine phosphatase (SHP)-1 and SHP-2, and the following inhibition of CD16/FcγRIIIa signaling pathway in human NK cells.

Clinical and Translational Updates

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