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Your Position: Start > CCL4

CCL4

Brief Information

Name:C-C motif chemokine 4
Target Synonym:LAG1,Secreted Protein G-26,Chemokine (C-C Motif) Ligand 4,C-C Motif Chemokine Ligand 4,AT744.1,ACT2,SCYA4,G-26,G-26 T-lymphocyte-secreted protein,HC21,Lymphocyte activation gene 1 protein,LAG-1,MIP-1-beta(1-69),Macrophage inflammatory protein 1-beta,MIP-1-beta,PAT 744,Protein H400,T-cell activation protein 2,ACT-2,SCYA2,MIP1B1,MIP1B,SIS-gamma,Small-inducible cytokine A4
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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CC4-H51H3 Human Human CCL4 Protein, His Tag
CC4-H51H3-structure
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Synonym Name

C-C motif chemokine 4,G-26 T-lymphocyte-secreted protein,HC21,Lymphocyte activation gene 1 protein,LAG-1,MIP-1-beta(1-69),Macrophage inflammatory protein 1-beta,MIP-1-beta,PAT 744,Protein H400,SIS-gamma,Small-inducible cytokine A4,T-cell activation protei

Background

CCL3, also know as MIP-1-beta, is monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B

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