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CLEC5A

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CLA-H5243 Human Human CLEC5A / MDL-1 Protein, His Tag, active dimer (MALS & SPR verified)
CLA-H5243-sds
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Part of Bioactivity data

CLA-H5243-SPR
CLEC5A SPR

Human Galectin-9 immobilized on CM5 Chip can bind Human CLEC5A, His Tag (Cat. No. CLA-H5243) with an affinity constant of 57.9 pM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
CLA-H5243-MALS-HPLC
CLEC5A MALS images

The purity of Human CLEC5A, His Tag (Cat. No. CLA-H5243) is more than 90% and the molecular weight of this protein is around 70-90 kDa verified by SEC-MALS.

Synonym Name

CLEC5A,CLECSF5,superfamilymember 5,C-type lectin domain family 5, member A,MDL1,MDL-1,DAP12-associating lectin 1

Background

CLEC5A, also known as MDL1 and MDL-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily.CLEC5A is expressed on monocytes, macrophages, and neutrophils. Its expression is up-regulated on monocytes in rheumatoid arthritis. CLEC5A with dnax-activation protein 12 and may play a role in cell activation. It also functions as a positive regulator of osteoclastogenesis. CLEC5A acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation .The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.

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