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Your Position: Start > SDF-1

SDF-1

Brief Information

Name:C-X-C motif chemokine ligand 12
Target Synonym:Pre-B Cell Growth-Stimulating Factor,SDF1B,C-X-C Motif Chemokine Ligand 12,SDF1,SDF-1,Chemokine (C-X-C Motif) Ligand 12,Stromal Cell-Derived Factor 1,CXCL12,HSDF-1,SCYB12,C-X-C Motif Chemokine 12,IRH,TLSF,Chemokine CXCL12,TLSF-A,TLSF-B,SDF-1b,SDF-1a,Intercrine Reduced In Hepatomas,TPAR1,PBSF,HIRH,SDF1A
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Phase 3 Clinical

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SD1-H5143 Human Human SDF-1 / CXCL12 Protein, His Tag
SD1-H5143-structure
SD1-H5143-sds
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Synonym Name

SDF-1,CXCL12,hSDF-1,IRH,hIRH,PBSF,SDF1,SDF1A,SDF1B

Background

Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
JVS-100 JVS-100; SRX-100; ACRX-100; GP-51801; GP51801 Phase 1 Clinical Cleveland Clinic Heart Failure; Ischemia; Surgical Wound; Peripheral Arterial Disease Details
MyoCell SDF-1 MyoCell SDF-1 Clinical U.S. Stem Cell Heart Failure Details
Emilimogene sigulactibac ILP100h Phase 2 Clinical Ilya Pharma AB Diabetic Foot; Wounds and Injuries Details
CK-0804 CK-0804 Phase 1 Clinical Cellenkos Inc Primary Myelofibrosis Details
Olaptesed Pegol NOX-A12 Phase 2 Clinical Noxxon Pharma Hematopoietic stem cell transplantation (HSCT); Glioblastoma; Pancreatic Neoplasms; Multiple Myeloma; Colorectal Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell Details
PTX-9908 PTX-9908 Phase 2 Clinical Pertinax Therapeutics Carcinoma, Hepatocellular Details
Dociparstat sodium ODSH; CX-01; PGX-100; PGX-ODSH-2013-AML-1 Phase 3 Clinical Paringenix Coronavirus Disease 2019 (COVID-19); Pancreatic Neoplasms; Myelodysplastic Syndromes; Protein-Losing Enteropathies; Pulmonary Disease, Chronic Obstructive; Leukemia, Myeloid, Acute; Acute Lung Injury Details

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