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Your Position: Start > FGF19

FGF19

Brief Information

Name:Fibroblast growth factor 19
Target Synonym:FGF-19
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Kat. Nr. Arten Produktbeschreibung Struktur Reinheit Merkmal
FG9-H51H3 Human Human FGF19 Protein, His Tag
FG9-H51H3-structure
FG9-H51H3-sds
FG9-H5253 Human Human FGF19 Protein, Fc Tag
FG9-H5253-structure
FG9-H5253-sds
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Part of Bioactivity data

FG9-H51H3-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human FGF R4, Fc Tag (Cat. No. FG4-H5253) on Protein A Biosensor, can bind Human FGF19, His Tag (Cat. No. FG9-H51H3) with an affinity constant of 63.5 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

Protocol
FG9-H51H3-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human FGF19, His Tag (Cat. No. FG9-H51H3) on HIS1K Biosensor, can bind Human FGF R4, Fc Tag (Cat. No. FG4-H5253) with an affinity constant of 16.6 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Customer Reviews

Synonym Name

FGF19/FGF-19/Fibroblast growth factor 19

Background

Fibroblast growth factor (FGF)19 is the first members of a new subfamily of FGFs and could act as hormones. During fetal life, FGF15/19 is involved in organogenesis, affecting the development of the ear, eye, heart, and brain. FGFs–FGFRs are involved in regulation of many biological processes such as embryonic development, cell proliferation, differentiation, and tissue repair. The dysregulation of FGF–FGFR  was observed in different types of diseases, disorders, and cancers. Notably, aberrant expression of FGF19/FGFR4 contributes to Hepatocellular Carcinoma progression.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Aldafermin NGM-282; M70; M-70; NGM282 Phase 2 Clinical Ngm Biopharmaceuticals Inc Liver Cirrhosis, Biliary; Constipation; Irritable Bowel Syndrome; Metabolic Dysfunction-Associated Steatotic Liver Disease; Renal Insufficiency; Bile acid malabsorption (BAM); Fibrosis; Cholangitis, Sclerosing; Diarrhea; Hepatic Insufficiency; Malabsorption Syndromes; Diabetes Mellitus Details
Aldafermin NGM-282; M70; M-70; NGM282 Phase 2 Clinical Ngm Biopharmaceuticals Inc Liver Cirrhosis, Biliary; Constipation; Irritable Bowel Syndrome; Metabolic Dysfunction-Associated Steatotic Liver Disease; Renal Insufficiency; Bile acid malabsorption (BAM); Fibrosis; Cholangitis, Sclerosing; Diarrhea; Hepatic Insufficiency; Malabsorption Syndromes; Diabetes Mellitus Details

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