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Your Position: Start > Transferrin R

Transferrin R

Brief Information

Name:Transferrin receptor protein 1
Target Synonym:TFRC,T9,sTfR,Transferrin receptor protein 1,TR,Transferrin Receptor,P90,Transferrin Receptor (P90, CD71),CD71 Antigen,IMD46,CD71,TfR1,Trfr,TfR
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:9
Lastest Research Phase:Approved

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Kat. Nr. Arten Produktbeschreibung Struktur Reinheit Merkmal
TFR-M82E3 Mouse Biotinylated Mouse Transferrin R / CD71 Protein, Avitag™,His Tag (MALS verified)
TFR-M82E3-structure
TFR-M82E3-sds
TFR-H5213 Human Human Transferrin R / CD71 Protein, Tag Free (MALS verified)
TFR-H5213-structure
TFR-H5213-sds
TFR-H82F3 Human Biotinylated Human Transferrin R / CD71 Protein, Fc,Avitag™
TFR-H82F3-structure
TFR-H82F3-sds
CHEK-ATP089 Human HEK293/Human Transferrin R Stable Cell Line
TFR-H5264 Human Human Transferrin R / CD71 Protein, Fc Tag (MALS verified)
TFR-H5264-structure
TFR-H5264-sds
TFR-R82E3 Rat Biotinylated Rat Transferrin R / CD71 Protein, His,Avitag™
TFR-R82E3-structure
TFR-R82E3-sds
TFR-M5263 Mouse Mouse Transferrin R Protein, Fc Tag (MALS verified)
TFR-M5263-structure
TFR-M5263-sds
TFR-R5249 Rat Rat Transferrin R / CD71 Protein, His Tag
TFR-R5249-structure
TFR-R5249-sds
TFR-M8249 Mouse Biotinylated Mouse Transferrin R / CD71 Protein, His Tag, ultra sensitivity (primary amine labeling) (MALS verified)
TFR-M8249-structure
TFR-M8249-sds
TFR-C8249 Cynomolgus Biotinylated Cynomolgus Transferrin R / CD71 Protein, His Tag, ultra sensitivity (primary amine labeling)
TFR-C8249-structure
TFR-C8249-sds
TFR-H82E5 Human Biotinylated Human Transferrin R / CD71 Protein, His,Avitag™ (MALS verified)
TFR-H82E5-structure
TFR-H82E5-sds
TFR-M524b Mouse Mouse Transferrin R / CD71 Protein, His Tag (MALS verified)
TFR-M524b-structure
TFR-M524b-sds
TFR-C524a Cynomolgus Cynomolgus Transferrin R / CD71 Protein, His Tag (MALS verified)
TFR-C524a-structure
TFR-C524a-sds
TFR-H8243 Human Biotinylated Human Transferrin R / CD71 Protein, His Tag, ultra sensitivity (primary amine labeling)
TFR-H8243-structure
TFR-H8243-sds
CD1-H5243 Human Human Transferrin R / CD71 Protein, His Tag (MALS verified)
CD1-H5243-structure
CD1-H5243-sds
ACRO Quality

Part of Bioactivity data

CHEK-ATP089-Cell-based assay
Transferrin R FACS

Fig. FACS analysis of Transferrin R on HEK293/Human Transferrin R Stable Cell Line.
FACS assay shows that Anti-Transferrin Receptor antibody can bind to HEK293/Human Transferrin R Stable Cell Line. HEK293/Human Transferrin R Stable Cell Line was red line, Negative control HEK293 cells was grey line (QC tested).

Protocol
TFR-H5264-SPR
Transferrin R SPR

Human Transferrin R Protein, Fc Tag (Cat. No. TFR-H5264) captured on Protein A Chip can bind Human Transferrin, His Tag (Cat. No. TRN-H4229) with an affinity constant of 0.491 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
TFR-H5213-ELISA
Transferrin R ELISA

Immobilized Human Transferrin R Protein, Tag Free (Cat. No. TFR-H5213) at 2 μg/mL (100 μL/well) can bind Biotinylated Human Transferrin Protein, His,Avitag (Cat. No. TRN-H82E3) with a linear range of 0.2-6.25 ng/mL (QC tested).

Protocol

Customer Reviews

Synonym Name

CD71,TFRC,TFR,sTfR,TfR1,Trfr,T9,p90

Background

CD antigen CD71 is also known as Transferrin receptor protein 1, TfR, sTfR, p90, TfR1, Trfr, which belongs to the peptidase M28 family and M28B subfamily. CD71 /TFR contains one PA (protease associated) domain. CD71 / TfR1 is required for iron delivery from transferrin to cells. CD71 is a potential new target in cases of human leukomia & lymphoma. CD71 /TFRC / TfR has been shown to interact with GABARAP and HFE.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Pabinafusp alfa JR-141 Approved Jcr Pharmaceuticals Co Ltd Japan Mucopolysaccharidosis II Jcr Pharmaceuticals Co Ltd 2021-03-23 Mucopolysaccharidosis II Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Human apotransferrin (Sanquin Blood Supply Foundation) Phase 3 Clinical Sanquin Plasma Products Bv Iron Metabolism Disorders; beta-Thalassemia Details
CX-2029 ABBV-2029; ABBV-CX-2029; CX-2029 Phase 2 Clinical Abbvie Inc, Cytomx Therapeutics Inc Head and Neck Neoplasms; Solid tumours; Esophageal Neoplasms; Lymphoma, Large B-Cell, Diffuse; Carcinoma, Non-Small-Cell Lung Details
DYNE-251 DYNE251 Phase 2 Clinical Dyne Therapeutics Inc Muscular Dystrophy, Duchenne Details
Lepunafusp alfa JR-171 Phase 2 Clinical Jcr Pharmaceuticals Co Ltd Mucopolysaccharidosis I Details
PPMX-T003 PPMX-T003 Phase 2 Clinical Perseus Proteomics Inc Leukemia; Polycythemia Vera Details
Delpacibart eteddesiran AOC-1001 Phase 2 Clinical Avidity Biosciences Inc Myotonic Disorders; Genetic Diseases, Inborn; Musculoskeletal Diseases; Muscular Disorders, Atrophic; Myotonic Dystrophy; Muscular Atrophy; Muscular Diseases; Heredodegenerative Disorders, Nervous System; Neuromuscular Diseases; Nervous System Diseases; Muscular Dystrophies; Neurodegenerative Diseases Details
Trontinemab RO-7126209; RG-6102 Phase 2 Clinical F. Hoffmann-La Roche Ltd Alzheimer Disease Details
INA-03 INA03 Phase 1 Clinical Inatherys Leukemia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute Details
ABX-1100 ABX-1100 Phase 1 Clinical Aro Biotherapeutics Co Glycogen Storage Disease Type II Details

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