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Your Position: Start > CCR8

CCR8

Brief Information

Name:C-C chemokine receptor type 8
Target Synonym:Chemokine (C-C) Receptor 8,CC Chemokine Receptor 8,CDw198 Antigen,C-C CKR-8,CC-CKR-8,CCR-8,CMKBRL2,C-C Motif Chemokine Receptor 8,CC chemokine receptor CHEMR1,C-C chemokine receptor type 8,Chemokine (C-C Motif) Receptor 8,C-C Chemokine Receptor Type 8,CC Chemokine Receptor CHEMR1,Chemokine Receptor-Like 1,Chemokine (C-C) Receptor-Like 2,CC-Chemokine Receptor Chemr1,CD_antigen=CDw198,Chemokine receptor-like 1,CKRL1,CKR-L1,CMKBR8,GPRCY6,GPR-CY6,TER1,CDw198,CY6
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:12
Lastest Research Phase:Phase 2 Clinical

Licensing

Project Name Modality Therapeutic Area Indications Stage Right Available
CCR8 Humanized Antibody Bispecific antibody Oncology/Cancer Solid Tumor Preclinical Global

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CC8-H82D3 Human Biotinylated Human CCR8 Protein, His,Flag Tag&Avitag™ (Detergent)
CC8-H82D3-structure
CC8-H52D7 Human Human CCR8 Protein, Flag,His Tag&Twin-Strep Tag (Nanodisc)
CC8-H52D6 Human Human CCR8 Protein, Flag,His Tag&Twin-Strep Tag (Detergent)
CHEK-ATP140 Human HEK293/Human CCR8 Stable Cell Line
CC8-H52P4 Human Human CCR8 Full Length Protein (VLP)
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Part of Bioactivity data

CHEK-ATP140-Cell-based assay
CCR8 FACS

Expression analysis of human CCR8 on HEK293/Human CCR8 Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human CCR8 Stable Cell Line or negative control cell using anti-human CCR8 antibody followed by staining with PE anti-human IgG antibody.

Protocol
CC8-H52D6-SPR
CCR8 SPR

Anti-CCR8 captured on Protein A Chip can bind Human CCR8 Protein, Flag,His Tag&Twin-Strep Tag (Cat. No. CC8-H52D6) with an affinity constant of 63.8 nM as determined in a SPR assay (in presence of DDM and CHS) (Biacore 8K) (Routinely tested).

Protocol
CC8-H52D6-ELISA
CCR8 ELISA

Immobilized Human CCR8 Protein, Flag,His Tag&Twin-Strep Tag (Cat. No. CC8-H52D6) at 0.5 μg/mL (100 μL/well) can bind Anti-CCR8 Antibody, Human IgG1 with a linear range of 0.2-6 ng/mL (QC tested).

Protocol

Synonym Name

CC chemokine receptor 8,CD198,,ChemR1,CKRL1,CKR-L1,CKRL1,CY6,GPRCL1,GPRCY6,GPR-CY6,TER-1

Background

This entry represents CC chemokine receptor 8 (CCR8), which it is expressed predominantly in lymphoid tissues and has also been found in glomerular podocytes and human umbilical vein endothelial cells (HUVECs). CCR8 is associated with Th2 lymphocytes, which are critical for allergy, and has a role in lymphocyte activation, migration, proliferation and differentiation and in allergic diseases. CCR8 binds to CCL1 (also known as I-309) and to CCL16 (also known as liver expressed chemokine). It also exhibits a high affinity for three chemokines of viral origin: vMIP-I, vMIP-II and vMCC-I.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
BMS-986340 BMS-986340 Phase 2 Clinical Eeig Bristol-Myers Squibb Manufacturing Company Bristol-Myers Squibb Srl Ovarian Neoplasms; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Neoplasms; Colorectal Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
S-531011 S-531011 Phase 2 Clinical Shionogi Inc Solid tumours Details
LM-108 LM-108 Phase 2 Clinical LaNova Medicines Ltd Solid tumours Details
BAY-3375968 BAY-3375968 Phase 1 Clinical Bayer AG Solid tumours; Neoplasms Details
ICP-B05 CM-369; ICPB05 Phase 1 Clinical Keymed Biosciences Co Ltd, InnoCare Pharma Ltd Hematologic Neoplasms; Solid tumours Details
HBM-1022 HBM-1022 Phase 1 Clinical Harbour Biomed Neoplasms Details
JTX-1811 JTX-1811; GS-1811 Phase 1 Clinical Jounce Therapeutics Inc Solid tumours Details
SRF-114 SRF-114 Phase 1 Clinical Surface Oncology Inc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Neoplasms Details
BGB-A3055 BGB-A3055 Phase 1 Clinical Beigene Ltd Solid tumours; Neoplasm Metastasis Details
ABBV-514 ABBV-514 Phase 1 Clinical Abbvie Inc Squamous Cell Carcinoma of Head and Neck; Carcinoma, Non-Small-Cell Lung Details
IPG-7236 IPG-7236; IPG-007 Phase 1 Clinical Nanjing Immunophage Biotech Co Ltd Solid tumours; Breast Neoplasms; Dermatitis, Atopic Details
ZL-1218 ZL-1218 Phase 1 Clinical Zai Lab (Shanghai) Co Ltd Solid tumours; Neoplasms Details
BMS-986340 BMS-986340 Phase 2 Clinical Eeig Bristol-Myers Squibb Manufacturing Company Bristol-Myers Squibb Srl Ovarian Neoplasms; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Neoplasms; Colorectal Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
S-531011 S-531011 Phase 2 Clinical Shionogi Inc Solid tumours Details
LM-108 LM-108 Phase 2 Clinical LaNova Medicines Ltd Solid tumours Details
BAY-3375968 BAY-3375968 Phase 1 Clinical Bayer AG Solid tumours; Neoplasms Details
ICP-B05 CM-369; ICPB05 Phase 1 Clinical Keymed Biosciences Co Ltd, InnoCare Pharma Ltd Hematologic Neoplasms; Solid tumours Details
HBM-1022 HBM-1022 Phase 1 Clinical Harbour Biomed Neoplasms Details
JTX-1811 JTX-1811; GS-1811 Phase 1 Clinical Jounce Therapeutics Inc Solid tumours Details
SRF-114 SRF-114 Phase 1 Clinical Surface Oncology Inc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Neoplasms Details
BGB-A3055 BGB-A3055 Phase 1 Clinical Beigene Ltd Solid tumours; Neoplasm Metastasis Details
ABBV-514 ABBV-514 Phase 1 Clinical Abbvie Inc Squamous Cell Carcinoma of Head and Neck; Carcinoma, Non-Small-Cell Lung Details
IPG-7236 IPG-7236; IPG-007 Phase 1 Clinical Nanjing Immunophage Biotech Co Ltd Solid tumours; Breast Neoplasms; Dermatitis, Atopic Details
ZL-1218 ZL-1218 Phase 1 Clinical Zai Lab (Shanghai) Co Ltd Solid tumours; Neoplasms Details

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