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FMC63

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Kat. Nr. Arten Produktbeschreibung Struktur Reinheit Merkmal
FM3-PFM721 Rabbit PE-Labeled Monoclonal Anti-FMC63 Antibody, Rabbit IgG (1G10) (0.03% Proclin)
FM3-PCFM7 Mouse PE-Labeled Monoclonal Anti-Human CD19 Antibody, Mouse IgG2a (FMC63)
MBS-C008 Mouse ActiveMax® Anti-FMC63 Antibody μBeads, premium grade (for cells)
FM3-PY54G0 Mouse PE-Labeled Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45), premium grade (Site-specific conjugation)
FM3-FY45G0 Mouse FITC-Labeled Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45), premium grade
FM3-AM534 Mouse Alexa Fluor™ 647-Labeled Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45)Star Staining
FM3-AY54A1 Mouse APC-Labeled Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) (Site-specific conjugation) (0.03% Proclin)
CD9-BV4324b Mouse Biotinylated FMC63 scFv, Fc,Avitag™ (MALS verified)
CD9-BV4324b-sds
RAB-P001 Rabbit Anti-CD19 (FMC63) CAR Immunogenicity ELISA Kit
FM3-PY54A2 Mouse PE-Labeled Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) (Site-specific conjugation) (0.03% Proclin)
CD9-M52Hb Mouse FMC63 scFv, His Tag (MALS verified)
CD9-M52Hb-sds
FM3-AY54P1 Mouse APC-Labeled Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) (Site-specific conjugation)
FM3-FY45P1 Mouse FITC-Labeled Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) (HEK293)
FM3-Y45A1 Mouse Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) (Carrier-free) (recommended for ADA assay)
FM3-Y45A1-sds
FM3-S93 Rabbit Rabbit Anti-Mouse FMC63 Polyclonal Antibody (recommended for ADA assay) (MALS verified)
FM3-S93-sds
FM3-BY54 Mouse Biotinylated Monoclonal Anti-FMC63 Antibody, Mouse IgG1, Avitag™ (Y45)
FM3-HPY53 Mouse PE-Labeled Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) (Site-specific conjugation) (Preservative free)
FM3-Y45P1 Mouse Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) (HEK293)
FM3-FY45 Mouse FITC-Labeled Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45)
FM3-Y45 Mouse Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45)
ACRO Quality

Part of Bioactivity data

FM3-PFM721-Cell-based assay
 FMC63 FACS

Flow cytometric analysis of Anti-CD19 CAR-293 cells staining with PE-Labeled Monoclonal Anti-FMC63 Antibody, Rabbit IgG1 (1G10) (Cat. No. FM3-PFM721) at 1:50 dilution (2 μL of the antibody stock solution corresponds to labeling of 1e6 cells in a final volume of 100 µL), compared with isotype control antibody. PE signal was used to evaluate the binding activity (QC tested).

FM3-PFM721-Cell-based assay
 FMC63 FACS

Non-specificity of PE-Labeled Monoclonal Anti-FMC63 Antibody, Rabbit IgG1 (1G10) (Cat. No. FM3-PFM721) binding to CD3+ cells present in human PBMC. Human PBMCs were simultaneously stained with FITC-labeled anti-CD3 antibody and PE-Labeled Monoclonal Anti-FMC63 Antibody, Rabbit IgG1 (1G10) (2 μL of the antibody stock solution corresponds to labeling of 5e5 cells in a final volume of 100 µL), washed and then analyzed with FACS. Both FITC and PE positive signals was used to evaluate the non-specific binding activity to human CD3+ cells (Routinely tested).

FM3-Y45A1-SPR
 FMC63 SPR

Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) (Cat. No. FM3-Y45A1) captured on CM5 chip via anti-mouse antibodies surface can bind FMC63 scFv with an affinity constant of 1.08 nM as determined in a SPR assay (Routinely tested).

CD9-M52Hb-ELISA
 FMC63 ELISA

Immobilized Human CD19 (20-291), Fc Tag, premium grade (Cat. No. CD9-H5251) at 5 μg/mL (100 μL/well) can bind FMC63 scFv, His Tag (Cat. No. CD9-M52Hb) with a linear range of 0.005-0.156 μg/mL (QC tested).

Customer Reviews

Synonym Name

Anti-FMC63 Ab & Anti-FMC63 scFv Antibody

Background

FMC63 is an IgG2a mouse monoclonal antibody specific for CD19, which is a target for the immunotherapy of B lineage leukaemias and lymphomas. FMC63 scFv is the most commonly used ectodomain component of CD19-specific CARs. So far, most of reported CART19 trials contain the anti-CD19 scFv derived from FMC63, including the two FDA-approved CARs Kymriah and Yescarta.

Clinical and Translational Updates

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