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FMC63

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Kat. Nr. Arten Produktbeschreibung Struktur Reinheit Merkmal
MBS-C008 Mouse ActiveMax® Anti-FMC63 Antibody μBeads, premium grade (for cells)
FM3-PY54G0 Mouse PE-Labeled Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45), premium grade (Site-specific conjugation)
FM3-FY45G0 Mouse FITC-Labeled Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45), premium grade
FM3-AM534 Mouse Alexa Fluor™ 647-Labeled Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45)Star Staining
FM3-AY54A1 Mouse APC-Labeled Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) (Site-specific conjugation) (0.03% Proclin)
CD9-BV4324b Mouse Biotinylated FMC63 scFv, Fc,Avitag™ (MALS verified)
CD9-BV4324b-sds
RAB-P001 Rabbit Anti-CD19 (FMC63) CAR Immunogenicity ELISA Kit
FM3-PY54A2 Mouse PE-Labeled Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) (Site-specific conjugation) (0.03% Proclin)
CD9-M52Hb Mouse FMC63 scFv, His Tag (SPR verified)
CD9-M52Hb-sds
FM3-AY54P1 Mouse APC-Labeled Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) (Site-specific conjugation)
FM3-FY45P1 Mouse FITC-Labeled Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) (HEK293)
FM3-Y45A1 Mouse Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) (Carrier-free) (recommended for ADA assay)
FM3-Y45A1-sds
FM3-S93 Rabbit Rabbit Anti-Mouse FMC63 Polyclonal Antibody (recommended for ADA assay) (MALS verified)
FM3-S93-sds
FM3-BY54 Mouse Biotinylated Monoclonal Anti-FMC63 Antibody, Mouse IgG1, Avitag™ (Y45)
FM3-HPY53 Mouse PE-Labeled Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) (Site-specific conjugation) (Preservative free)
FM3-Y45P1 Mouse Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) (HEK293)
FM3-FY45 Mouse FITC-Labeled Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45)
FM3-Y45 Mouse Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45)
ACRO Quality

Part of Bioactivity data

FM3-AM534-Cell-based assay
 FMC63 CAR_T

5e5 of anti-CD19 CAR-293 cells were stained with 100 μL of 3 μg/mL of Alexa Fluor 647-Labeled Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) (Cat. No. FM3-AM534) and negative control respectively (Fig. C and B), and non-transfected 293 cells were used as a control (Fig. A). Alexa 647 signal was used to evaluate the binding activity (QC tested).

CD9-M52Hb-SPR
 FMC63 SPR

Human CD19 (20-291), Fc Tag (Cat. No. CD9-H5251) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind FMC63 scFv, His Tag (Cat. No. CD9-M52Hb) with an affinity constant of 0.668 nM as determined in a SPR assay (Biacore 8K) (QC tested).

FM3-Y45A1-SPR
 FMC63 SPR

Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) (Cat. No. FM3-Y45A1) captured on CM5 chip via anti-mouse antibodies surface can bind FMC63 scFv with an affinity constant of 1.08 nM as determined in a SPR assay (Routinely tested).

Customer Reviews

Synonym Name

Anti-FMC63 Ab & Anti-FMC63 scFv Antibody

Background

FMC63 is an IgG2a mouse monoclonal antibody specific for CD19, which is a target for the immunotherapy of B lineage leukaemias and lymphomas. FMC63 scFv is the most commonly used ectodomain component of CD19-specific CARs. So far, most of reported CART19 trials contain the anti-CD19 scFv derived from FMC63, including the two FDA-approved CARs Kymriah and Yescarta.

Clinical and Translational Updates

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