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Product Details
Synonyms
GDF-8, Myostatin, GDF8, MSTN, Growth, differentiation factor 8
Source
Human / Mouse / Rat GDF-8 Protein, Tag Free (GD8-H5344) is expressed from CHO cells. It contains AA Asp 267 - Ser 375 (Accession # O14793). In the region Asp 267 - Ser 375, the amino acid sequences of Human, Mouse and Rat GDF-8 are identical.
Predicted N-terminus: Asp 267
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries no "tag".
The protein has a calculated MW of 12.4 kDa. The protein migrates as 12.0 kDa under reducing (R) condition, and 11 kDa and 25 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>90% as determined by SDS-PAGE.
Formulation
Lyophilized from 0.22 μm filtered solution in 50 mM HAC, pH3.0 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Shipping and Storage
This product is shipped at ambient temperature.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Performance Data
SDS-PAGE
Human / Mouse / Rat GDF-8 Protein, Tag Free on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).
Bioactivity-ELISA
Immobilized Human / Mouse / Rat GDF-8 Protein, Tag Free (Cat. No. GD8-H5344) at 1 μg/mL (100 μL/well) can bind Biotinylated Human Activin RIIB Protein, Fc,Avitag (Cat. No. ACB-H82F3) with a linear range of 0.1-8 ng/mL (QC tested).
Protocol
Immobilized Human / Mouse / Rat GDF-8 Protein, Tag Free (Cat. No. GD8-H5344) at 2 μg/mL (100 μL/well) can bind Human Follistatin Protein, Fc Tag (Cat. No. FON-H5256) with a linear range of 1-31 ng/mL (Routinely tested).
Protocol
Immobilized Human / Mouse / Rat GDF-8 Protein, Tag Free (Cat. No. GD8-H5344) at 1 μg/mL (100 μL/well) can bind Human Activin RIIB Protein, Fc Tag (Cat. No. ACB-H5254) with a linear range of 0.1-2 ng/mL (Routinely tested).
Protocol
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Background
Recent Advances
Drug Development Progress- English Name：
Growth/differentiation factor 8
- Category：
- Approved Drugs：
0 Details
- Drugs in Clinical Trials：
8 Details
- Highest Development Stage：
NDA/BLA
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