The immune system's fundamental function depends on exquisitely regulated self-antigen recognition and tolerance mechanisms - the cornerstone of immunological homeostasis. This critical balance is maintained through complementary central tolerance (clonal deletion in thymus/bone marrow) and peripheral tolerance. However, when the immune system faces "immune warning signals", this balance may be threatened, increasing the risk of potential Autoimmune Disease (AIDs). According to statistics, about 10% of healthy individuals have detectable low levels of autoantibodies in their serum. These antibodies, though not causing noticeable symptoms, indicate a potential risk mechanism of immune imbalance.
Click to view ACROBiosystems Solutions for AIDs Drug Development
"Where Proteins and lnnovation Advance Biomedicine", ACROBiosystems collaborates with leading global pharmaceutical companies to provide comprehensive solutions for AIDs drug development. Our integrated portfolio encompasses high-quality biological reagents including recombinant proteins, antibodies, engineered cell lines, specialized assay kits and organoids, as well as one-stop services. We support the entire drug development process through integrated services spanning from drug discovery and development, manufacturing and quality control to preclinical and clinical studies.
| Discovery & Development | Manufacturing & Quality Control | Preclinical & Clinical Studies |
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Target Proteins 100+ AIDs-related targets covered Functional Cell Lines TR-FRET Kits Inhibitor Screening Kits Molecular Interaction Analysis Services (SPR & BLI) ... |
GMP-grade Reagents Recombinant Factor C Endotoxin Detection Kit Residual Detection Kits ... |
Organoid-related Solutions Anti-Idiotypic Antibody Development Service Cytokine Detection ELISA Kits ... |
Key signaling pathways in IBD [1]
Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract caused by immune dysregulation, encompassing both Crohn’s disease and ulcerative colitis. Its pathogenesis involves complex interactions among the immune system, gut microbiota, and environmental factors. Aberrantly activated T and B cells secrete inflammatory cytokines such as TNF-α, IL-17, and TL1A, leading to intestinal tissue damage. Key immune mechanisms include the Th17 pathway, JAK/STAT signaling, TL1A/DR3 axis, and integrin-mediated cell adhesion. Dysregulation of these pathways collectively drives the chronic intestinal inflammation and disease progression observed in IBD.
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