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PSMA

PSMA Overview

English NameProstate-Specific Membrane AntigenApproved Drugs5
Drugs in Clinical Trials111Target SynonymEC:3.4.17.21，GIG27，Glutamate carboxypeptidase II，NAALADase I，FOLH，Cell growth-inhibiting gene 27 protein，PSM，N-acetylated-alpha-linked acidic dipeptidase I，GCPII，Folylpoly-gamma-glutamate carboxypeptidase，Folate hydrolase 1，FOLH1，Pteroylpoly-Gamma-Glutamate Carboxypeptidase，Membrane Glutamate Carboxypeptidase，Glutamate Carboxypeptidase 2，Glutamate Carboxylase II，NAALAD1，FGCP，PSMA，MGCP，Folate Hydrolase (Prostate-Specific Membrane Antigen) 1，N-Acetylated Alpha-Linked Acidic Dipeptidase 1，Prostate Specific Membrane Antigen Variant F，Prostate-Specific Membrane Antigen，EC 3.4.17.21，NAALAdase，GCP2
Highest Development StagePhase 3 Clinical
English NameProstate-Specific Membrane Antigen
Target SynonymEC:3.4.17.21，GIG27，Glutamate carboxypeptidase II，NAALADase I，FOLH，Cell growth-inhibiting gene 27 protein，PSM，N-acetylated-alpha-linked acidic dipeptidase I，GCPII，Folylpoly-gamma-glutamate carboxypeptidase，Folate hydrolase 1，FOLH1，Pteroylpoly-Gamma-Glutamate Carboxypeptidase，Membrane Glutamate Carboxypeptidase，Glutamate Carboxypeptidase 2，Glutamate Carboxylase II，NAALAD1，FGCP，PSMA，MGCP，Folate Hydrolase (Prostate-Specific Membrane Antigen) 1，N-Acetylated Alpha-Linked Acidic Dipeptidase 1，Prostate Specific Membrane Antigen Variant F，Prostate-Specific Membrane Antigen，EC 3.4.17.21，NAALAdase，GCP2
Approved Drugs5
Drugs in Clinical Trials111
Highest Development StagePhase 3 Clinical

PSMA Product List

  • Product Category

    Protein (13)Beads (1)Antibody (1)Cell (2)Kits (1)

  • Product Status

    Launched (17)In Research (1)

  • Species

    Human (10)Cynomolgus (2)Mouse (4)Rat (1)Rabbit (1)

  • Tag

    His Tag (6)His Tag & Avi Tag (3)Fc Tag (2)- (5)Fc Tag & Avi Tag (2)

  • Conjugate

    Unconjugated (7)Biotin-labeled (5)FITC Labeled (1)- (4)PE Labeled (1)

Total: 18
  • 1
  • 2

PSMA Background

Prostate-specific membrane antigen (PSMA) is also known as Folate hydrolase 1 (FOLH1), Glutamate carboxypeptidase 2 (GCP2), N-acetylated-alpha-linked acidic dipeptidase I (NAALAD1), which belongs to the peptidase M28 family and M28B subfamily. FOLH1 / PSMA is stable at pH greater than 6.5. FOLH1 / PSMA is a type II transmembrane zinc metallopeptidase that is most highly expressed in the nervous system, prostate, kidney, and small intestine. FOLH1 / GCP-2 is homodimer and binds 2 zinc ions per subunit, and required for NAALADase activity. The catalytic activity of PSMA involved in releasing of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly – gamma - glutamates. FOLH1 / GCP-2 / PSMA has both folate hydrolase and N – acetylated – alpha – linked - acidic dipeptidase (NAALADase) activity and has a preference for tri-alpha-glutamate peptides. GCP-2 / PSMA involved in prostate tumor progression and also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.

PSMA Synonyms

FOLH1,PSMA,GIG27,FOLH,NAALAD1,PSM,NAALADase I,GCPII,FGCP

Product Reviews

  • M***n2025-09-15
    1People Like
    Biotinylated Human PSMA / FOLH1 Protein, His,Avitag™, premium grade
    I have several Scientists that use Acro Proteins. We used to order these on Fisher, however, I have now changed to directly through Acro as their ordering is so much easier and they fulfill order promptly and perfectly. We are starting to use more Acro products and I am excited to continue to work with this company and keep getting the same great quality of products, ease of ordering, and super quick fulfillment.
  • T***n2023-06-29
    0People Like
    Biotinylated Human PSMA / FOLH1 Protein, His,Avitag™, premium grade
    I ordered this product on Monday and received it by Friday! The product came neatly packed in dry ice with secure packaging. The reagent gave me good standard curves as I titrate the concentration of PSMA for my assay. I will order again next time.
  • T***n2021-09-22
    2People Like
    Biotinylated Human PSMA / FOLH1 Protein, His,Avitag™, premium grade
    I highly recommend for this supplier company .I received this order on Sep . 03 /2021 with enough dry ice for - 80C. Thank you acrobiosystems.
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