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Mesothelin

Mesothelin

Mesothelin Overview

Molecule Name
Mesothelin
Synonyms
MSLN,Mesothelin,MPF
Drug Development Progress
Drugs in Clinical Trials59
Approved Drugs0
Highest Development StagePhase 2 Clinical
Target Synonym
Pre-pro-megakaryocyte-potentiating factor，Mesothelin，MSLN，CAK1 Antigen，MPF，Soluble MPF Mesothelin Related Protein，Megakaryocyte Potentiating Factor，SMRP，CAK1
Background
Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

Mesothelin Product List

Species
  • Human（24）
  • Mouse（3）
  • Cynomolgus（2）
  • Rat（1）
Tag
  • His Tag（17）
  • Fc Tag（7）
  • His Tag & Avi Tag（5）
  • Fc Tag & Avi Tag（1）
Host
  • HEK293（30）
Conjugate
  • Unconjugated（10）
  • Biotin-labeled（8）
  • FITC Labeled（4）
  • APC Labeled（2）
  • PE Labeled（2）
  • AF488 Labeled（1）
  • AF555 Labeled（1）
  • AF647 Labeled（1）
  • GFP Fusion（1）
Grade
  • RUO（26）
  • PG (pre-GMP)（4）
Low Endotoxin
  • No（30）
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&Price
Mesothelin
HOTAvitag
MSN-H82E7
Biotinylated Human Mesothelin / MSLN (296-600) Protein, His,Avitag™ (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$360.00

25ug
Mesothelin
HOT
MSN-H522a
Human Mesothelin / MSLN (296-580) Protein, His Tag, premium grade (Mass Spec verified)
Human
HEK293
MALSSDS-PAGE
ELISABLIFlow

$475.00

100ug
Mesothelin
HOTDMF
MSN-HP2H5
PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag (Site-specific conjugation)
Human
HEK293
Flow

$415.00

25tests
Mesothelin
HOTAvitagDMF
MSN-H82E9
Biotinylated Human Mesothelin / MSLN (296-580) Protein, His,Avitag™, premium grade
Human
HEK293
MALSSDS-PAGE
ELISAFlow

$280.00

25ug
Mesothelin
HOT
MSN-HP2H8
PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
Human
HEK293
Flow

$415.00

25tests
Mesothelin
MSN-C52H6
Cynomolgus Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)
Cynomolgus
HEK293
MALSSDS-PAGE
ELISABLI

$360.00

100ug
Mesothelin
Avitag
MSN-C82E3
Biotinylated Cynomolgus Mesothelin / MSLN Protein, His,Avitag™ (MALS verified)
Cynomolgus
HEK293
MALSSDS-PAGE
ELISA

$360.00

25ug
Mesothelin
MSN-H5222
Human Mesothelin / MSLN (37-286) Protein, His Tag (MALS verified)
Human
HEK293
MALSSDS-PAGE

$290.00

100ug
Mesothelin
MSN-H5253
Human Mesothelin / MSLN (296-580) Protein, Fc Tag, premium grade
Human
HEK293
MALSSDS-PAGE
ELISAFlow

$290.00

100ug
Mesothelin
MSN-H5267
Human Mesothelin / MSLN (391-598) Protein, Fc Tag (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$455.00

100ug
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FAQ

Can fluorescent mesothelin reagents be used for flow cytometry?

Selected products are labeled with FITC, PE, APC, Alexa Fluor dyes or GFP. Choose the fluorophore according to the instrument configuration and the other colors in the panel.

Are biotinylated mesothelin proteins available?

Yes. Selected mesothelin proteins are offered in biotinylated His/Avi or Fc/Avi formats. Verify the biotinylation approach and validation data for the exact product.

How is MSLN used in CAR-T cell therapy development?

MSLN is a well-established tumor-associated antigen for CAR-T cell development. MSLN proteins can be used to evaluate CAR binding, target recognition, and the specificity and activity of MSLN-targeted CAR-T cells.

Which species can I select for a mesothelin protein study?

Human, mouse, cynomolgus and rat mesothelin products are listed. Match the species to the therapeutic binder, antibody and biological model used in the assay.

What mesothelin reagent types are available?

The collection includes recombinant mesothelin proteins, magnetic beads, cell-culture-grade beads and mesothelin-expressing cell products.
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Resources

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
RC-88RC-88Phase 2 Clinical
Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Neoplasms; Peritoneal Neoplasms; Solid tumours
Details
iCasp9M28ziCasp9M28zPhase 2 ClinicalMemorial Sloan Kettering Cancer Center
Breast Neoplasms; Lung Neoplasms; Mesothelioma; Neoplasm Metastasis; Pleural Diseases
Details
Anetumab ravtansineBAY-94-9343; BAY-94-9343-SPDB-DM4; Anti-mesothelin antibody-drug conjugate BAY 94-9343Phase 2 ClinicalBayer AG, Morphosys Ag
Carcinoma, Endometrioid; Fallopian Tube Neoplasms; Lung Neoplasms; Mesothelioma; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Solid tumours
Details
Gavocabtagene autoleucelTC-210Phase 2 ClinicalTcr2 Therapeutics Inc
Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Mesothelioma; Ovarian Neoplasms
Details
LMB-100LMB-100; RG-7787; RO-6927005Phase 2 ClinicalF. Hoffmann-La Roche Ltd
Adenocarcinoma of Lung; Carcinoma; Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Lung Neoplasms; Mesothelioma; Neoplasms; Neoplasms, Mesothelial; Pancreatic Neoplasms; Pleural Effusion, Malignant
Details
Anti-CTLA-4 and PD-1 CAR-T cell therapy (Shanghai Cell Therapy Research Institute)Phase 2 ClinicalShanghai Cell Therapy Research Institute
Neoplasms
Details
EB-DNK101EB-DNK101Phase 2 ClinicalBeijing Biotech
Carcinoma, Pancreatic Ductal
Details
EB-NK-MM (MSLN/MUC16)EB-NK-MMPhase 2 ClinicalBeijing Biotech
Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Peritoneal Neoplasms
Details
EB-NK-MF (MSLN/FRalpha)EB-NK-MFPhase 2 ClinicalBeijing Biotech
Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Glioblastoma; Glioma; Peritoneal Neoplasms
Details
EB-DuoNK-MSLN/HER2 cell therapy (Beijing Biotech)Phase 2 ClinicalBeijing Biotech
Carcinoma, Non-Small-Cell Lung
Details
MSLN CAR-T cell therapy (Shenzhen University General Hospital)Phase 2 ClinicalShenzhen University General Hospital
Solid tumours
Details
A2B-543A2B543Phase 2 ClinicalA2 Biotherapeutics Inc
Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Mesothelioma; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Rectal Neoplasms; Solid tumours
Details
Mesothelin targeting CAR-T cell therapy (Essen Biotech)Phase 2 ClinicalEssen Biotech
Pancreatic Neoplasms
Details
HY-05350HY-0005; HY-05350Phase 2 ClinicalSichuan Huiyu Seacross Pharma Technology Ltd
Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Mesothelioma; Ovarian Neoplasms; Pancreatic Neoplasms; Solid tumours
Details
TCR-like CAR-T Cell Therapy(Zhongda Hospital Southeast University)Phase 2 ClinicalZhongda Hospital Southeast University
Ovarian Neoplasms
Details
CD40 ligand expressing MSLN-CAR T cellsPhase 2 ClinicalPla General Hospital
Solid tumours
Details
A2B-694A2B-694; A2B694Phase 2 ClinicalA2 Biotherapeutics Inc
Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Mesothelioma; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Rectal Neoplasms; Solid tumours
Details
RNA-Meso-CIR-TRNA-Meso-CIR-TPhase 1 ClinicalNovartis Pharma Ag, University Of Pennsylvania
Mesothelioma
Details
CART-mesoCART-mesoPhase 1 ClinicalNovartis Pharma Ag, University Of Pennsylvania
Adenocarcinoma of Lung; Breast Neoplasms; Carcinoma, Ovarian Epithelial; Carcinoma, Pancreatic Ductal; Fallopian Tube Neoplasms; Mesothelioma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms
Details
anti-MESO CAR-T cells (Zhejiang University)UCLM802; UCLM-802Phase 1 ClinicalHrain Biotechnology Co Ltd, Zhejiang University
Ovarian Neoplasms; Solid tumours
Details
Anti-mesothelin thorium-227 labeled antibody chelator conjugateBAY-2287411Phase 1 ClinicalBayer AG
Carcinoma, Pancreatic Ductal; Mesothelioma; Ovarian Neoplasms
Details
huMesoCARTMSLN-12; MSLN-18; SS-1; MSLN-23; MSLN-11; MSLN-14; MSLN-16; MSLN-21; MSLN-5Phase 1 ClinicalUniversity Of Pennsylvania
Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Fallopian Tube Neoplasms; Mesothelioma; Metastatic breast cancer; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms
Details
PSMA/NKG2DL/FAP-targeted Hi-TCR-T cellsPhase 1 ClinicalShenzhen Misheng Biotechnology Co Ltd
Prostatic Neoplasms; Solid tumours
Details
GC-503GC-503Phase 1 ClinicalGracell Biotechnologies Inc
Solid tumours
Details
iCasp9M28z T cellsPhase 1 ClinicalMemorial Sloan Kettering Cancer Center
Breast Neoplasms; Lung Neoplasms; Mesothelioma
Details
anti-mesothelin CAR T-cell therapy (Chinese PLA General Hospital)Phase 1 ClinicalPla General Hospital
Solid tumours
Details
HPN-536HPN-536Phase 1 ClinicalHarpoon Therapeutics
Neoplasms
Details
AB-1015AB-1015Phase 1 ClinicalArsenal Biosciences Inc
Carcinoma, Ovarian Epithelial; Ovarian Neoplasms
Details
SynKIR-110SynKIR™-110; SynKIR-mesoPhase 1 ClinicalVerismo Therapeutics Inc
Cholangiocarcinoma; Mesothelioma; Ovarian Neoplasms
Details
KT-032KT-032Phase 1 ClinicalNanjing Kati Medical Technology Co Ltd
Mesothelioma; Ovarian Neoplasms; Pancreatic Neoplasms; Solid tumours
Details
NI-1801NI-1801Phase 1 ClinicalLight Chain Bioscience Ltd
Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Pancreatic Ductal; Solid tumours; Triple Negative Breast Neoplasms
Details
UCLM-805UCLM-805; UCLM805Phase 1 ClinicalUTC Therapeutics Inc
Solid tumours
Details
FC-004FC004; FC-004Phase 1 ClinicalCancer Center Of Sun Yat Sen University
Ovarian Neoplasms
Details
MSLN-CAR T cells(Yihao Biotech)SHYH006; SHYH-006Phase 1 ClinicalShanghai Yihao Biotechnology Co Ltd
Ovarian Neoplasms
Details
Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells therapy(NIH)TNhYP218; TNhYP217; TNhYP-218; TNhYP-217Phase 1 ClinicalNational Cancer Institute
Colonic Neoplasms; Lung Neoplasms; Mesothelioma; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms; Thymus Neoplasms
Details
Mesothelin x CD3 Bispecific Antibody(Integral Molecular)CT-95; LNK101; LNK-101Phase 1 ClinicalIntegral Molecular Inc
Carcinoma, Ovarian Epithelial; Cholangiocarcinoma; Colorectal Neoplasms; Mesothelioma; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Solid tumours
Details
BZT-2312BZT-2312Phase 1 ClinicalShanghai Cell Therapy Group Co Ltd
Solid tumours
Details
JNJ-79032421JNJ-79032421; JNJ-2421Phase 1 ClinicalJanssen Research & Development Llc
Solid tumours
Details
YL-215YL215; YL-215Phase 1 ClinicalMediLink Therapeutics Co Ltd
Solid tumours
Details
GPC3/Mesothelin-CAR-γδT Cells therapy(Second Affiliated Hospital Of Guangzhou Medical University)Phase 1 ClinicalSecond Affiliated Hospital Of Guangzhou Medical University
Liver Neoplasms; Lung Neoplasms; Mesothelioma; Pancreatic Neoplasms; Solid tumours
Details
OPB-101OPB-101Phase 1 ClinicalOutpace Bio Inc
Ovarian Diseases; Ovarian Neoplasms
Details
AMG 305AMG 305; AMG-305Phase 1 ClinicalAmgen Inc
Solid tumours
Details
Mesothelin-CAR-T Cells (Fapon Biopharma)Phase 1 ClinicalGuangdong Fapon Biopharma Inc
Pancreatic Neoplasms
Details
UCMYM-802UCMYM802; UCMYM-802Phase 1 ClinicalUTC Therapeutics Inc
Bile Duct Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Mesothelioma; Ovarian Neoplasms; Pancreatic Neoplasms; Rectal Neoplasms; Solid tumours
Details
HBM-9033HBM9033; SGN-MesoC2; HBM-9033; PF-08052666Phase 1 ClinicalNona Biosciences
Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Endometrial Neoplasms; Mesothelioma; Ovarian Neoplasms; Pancreatic Neoplasms; Solid tumours
Details
LD-013LD013; LD-013Phase 1 ClinicalNanjing Blue Shield Biotech Co Ltd
Ovarian Neoplasms; Solid tumours
Details
Ori-C-613Ori-C-613; OriC-613; Ori-C613Phase 1 ClinicalOriCell Therapeutics Co Ltd
Solid tumours
Details
RD-138RD-138Phase 1 ClinicalNanjing Iaso Biotherapeutics Co Ltd
Multiple Myeloma
Details
RD-133RD133Phase 1 ClinicalNanjing Iaso Biotherapeutics Co Ltd
Neoplasms; Solid tumours
Details
PM-3006PM-3006Phase 1 Clinical
Details
Anti-mesothelin CAR-NK cell therapy(Guojianchengnuo)ALF-101Phase 1 ClinicalGuojianchengnuo Biotechnology (Beijing) Co Ltd
Carcinoma, Ovarian Epithelial
Details
InezetamabAMG-994Phase 1 ClinicalAmgen Inc
Solid tumours
Details
ATA-2271ATA-2271Phase 1 ClinicalAtara Biotherapeutics Inc, Bayer AG, Memorial Sloan Kettering Cancer Center
Adenocarcinoma; Breast Neoplasms; Diabetes Mellitus; Esophageal adenocarcinoma; Esophageal Neoplasms; Mesothelioma; Neoplasms; Peritoneal Neoplasms; Stomach Neoplasms
Details
αPD1-MSLN-CAR T cell therapy (Shanghai Cell Therapy Group Co.,Ltd)BZDS1901; BZDS-1901; BZD1901Phase 1 ClinicalShanghai Cell Therapy Group Co Ltd
Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Mesothelioma; Ovarian Neoplasms; Solid tumours
Details
KD-021KD-021Phase 1 ClinicalNanjing Kaidi Medical Technology Co Ltd
Neoplasms
Details
anti-mesothelin CAR T-cell therapy (Shenzhen BinDeBio)ClinicalShenzhen Bindebio Ltd
Pancreatic Neoplasms
Details
Universal Chimeric Antigen Receptor T-Cell Immunotherapy(Calmhome Cell and Gene Engineering Institute)CHT-102; CHT102ClinicalNanjing Calmhome Cell and Gene Engineering Institute Co Ltd, Tianjin Medical University Cancer Institute And Hospital
Pancreatic Neoplasms; Solid tumours
Details
Anti-mesothelin CAR T cell therapy (UTC Therapeutics Inc)ClinicalUTC Therapeutics Inc
Solid tumours
Details
Anti-mesothelin CAR-T (Pregene)ClinicalPregene (Shenzhen) Biotechnology Co Ltd
Hydrothorax
Details
Customer Reviews
  • B***a2023-07-11
    APC-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
    This is one of the only conjugated mesothelin proteins available on the market! It has great specificity for flow cytometry staining, this has been a game changer for us to measure human mesothelin present in our samples with an easy and quick one-step staining method. This is a great quality product and we will be ordering so many more in the future!

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