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Product Details
Synonyms
TACSTD2, GA733-1, M1S1, TROP2
Source
Cynomolgus TROP-2 Protein, His Tag (TR2-C52H5) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Thr 274 (Accession # XP_005543292.2).
Predicted N-terminus: Gln 31
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 29.4 kDa. The protein migrates as 40-53 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 0.01 EU per μg by the LAL method / rFC method.
Purity
>90% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System
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Data Display
SDS-PAGE
Cynomolgus TROP-2 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).
SEC-MALS
The purity of Cynomolgus TROP-2 Protein, His Tag (Cat. No. TR2-C52H5) is more than 95% and the molecular weight of this protein is around 30-45 kDa verified by SEC-MALS.
Report
Bioactivity-ELISA
Immobilized Cynomolgus TROP-2 Protein, His Tag (Cat. No. TR2-C52H5) at 1 μg/mL (100 μL/well) can bind Mouse Monoclonal Antibody Against Human TROP-2 Protein,Mouse IgG1 with a linear range of 0.1-2 ng/mL (QC tested).
Protocol
Bioactivity-SPR
Mouse Monoclonal Antibody Against Human TROP-2 captured on CM5 chip via anti-mouse antibodies surface can bind Cynomolgus TROP-2 Protein, His Tag (Cat. No. TR2-C52H5) with an affinity constant of 8.42 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Protocol
User Reviews Publish Comment
Background Introduction
Frontier Progress
Drug Development Progress- English Name：
Tumor-associated calcium signal transducer 2
- Category：
- Listed Drugs Count：
3 Details
- Clinical Drugs Count：
47 Details
- Highest R&D Stage：
Approved
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