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Product Details
Synonyms
CD71, TFRC, TFR, sTfR, TfR1, Trfr, T9, p90
Source
Human Transferrin R Protein, Fc Tag (TFR-H5264) is expressed from human 293 cells (HEK293). It contains AA Cys 89 - Phe 760 (Accession # P02786-1).
Predicted N-terminus: Cys 89
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 101.6 kDa. The protein migrates as 95-120 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 0.01 EU per μg by the LAL method / rFC method.
Purity
>95% as determined by SDS-PAGE.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Shipping and Storage
This product is shipped at ambient temperature.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Performance Data
SDS-PAGE
Human Transferrin R Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).
SEC-MALS
The purity of Human Transferrin R Protein, Fc Tag (Cat. No. TFR-H5264) is more than 85% and the molecular weight of this protein is around 200-240 kDa verified by SEC-MALS.
Report
Bioactivity-ELISA
Immobilized Human Transferrin Protein, His Tag (Cat. No. TRN-H52H3) at 2 μg/mL (100 μL/well) can bind Human Transferrin R Protein, Fc Tag (Cat. No. TFR-H5264) with a linear range of 0.039-0.625 μg/mL (QC tested).
Protocol
Bioactivity-SPR
Human Transferrin R Protein, Fc Tag (Cat. No. TFR-H5264) captured on Protein A Chip can bind Human Transferrin, His Tag with an affinity constant of 0.491 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Protocol
Brain-penetrant, anti-amyloid, bispecific antibody immobilized on CM5 Chip can bind Human Transferrin R Protein, Fc Tag (Cat. No. TFR-H5264) with an affinity constant of 33.4 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Protocol
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Background
Recent Advances
Drug Development Progress- English Name：
Transferrin receptor protein 1
- Category：
- Approved Drugs：
1 Details
- Drugs in Clinical Trials：
15 Details
- Highest Development Stage：
Approved
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