Biotinylated Human Tau-441 / 2N4R (1-441) Protein, His,Avitag™ (MALS verified)

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Cat. No. / Size
Price
Qty
TAU-H81E3-100ug
$305.00
TAU-H81E3-1mg
$2046.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    DDPAC, FTDP-17, MAPT, MSTD, MTBT1, Tau, PHF-tau, TAU

  • Source

    Biotinylated Human Tau-441 / 2N4R (1-441) Protein, His,Avitag (TAU-H81E3) is expressed from E. coli cells. It contains AA Met 1 - Leu 441 (Accession # P10636-8).

    Predicted N-terminus: Met 1

    Request for sequence
  • Molecular Characterization

    Tau Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 49.5 kDa. The protein migrates as 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

  • Labeling

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

  • Protein Ratio

    Passed as determined by the HABA assay / binding ELISA.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Supplied as 0.2 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    Tau SDS-PAGE

    Biotinylated Human Tau-441 / 2N4R (1-441) Protein, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Tau SEC-MALS

    The purity of Biotinylated Human Tau-441 / 2N4R (1-441) Protein, His,Avitag (Cat. No. TAU-H81E3) is more than 90% and the molecular weight of this protein is around 50-65 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     Tau ELISA

    Immobilized Biotinylated Human Tau-441 / 2N4R (1-441) Protein, His,Avitag (Cat. No. TAU-H81E3) at 5 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Monoclonal Anti-Human tau Antibody, Mouse IgG1 (6G7C8) (Cat. No. TAU-MY2102) with a linear range of 0.02-10 μg/mL (QC tested).

    Protocol

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Background

Tau 441 (2N4R) is the longest human brain tau isoform, containing two N-terminal inserts and four microtubule-binding repeats. It stabilizes neuronal microtubules, but its pathological hyperphosphorylation leads to paired helical filament aggregation. Tau 441 constitutes the core component of neurofibrillary tangles in Alzheimer's disease and related tauopathies.

Recent Advances

 
Drug Development Progress
  • English Name:

    Microtubule-associated protein tau

  • Category:

  • Approved Drugs:

    1 Details

  • Drugs in Clinical Trials:

    46 Details

  • Highest Development Stage:

    Approved

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