Human Claudin-18.1 (1-200) Protein, His,Flag Tag (Detergent)

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Cat. No. / Size
Price
Qty
CL1-H51D3-20ug
$ 496.00
CL1-H51D3-100ug
$ 988.00
CL1-H51D3-500ug
$ 4305.00

Product Details

  • Application

    1. Immunization
    2. Affinity testing (SPR / BLI)
    3. Screening (ELISA)
  • Synonyms

    Claudin-18.1, CLDN18, Claudin-18

  • Source

    Detergent Human Claudin-18.1 (1-200) Protein, His,Flag Tag (CL1-H51D3) is expressed from E. coli system. It contains AA Met 1 - Ala 200 (Accession # P56856-1).

    Predicted N-terminus: Met

  • Molecular Characterization

    Claudin-18.1 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the N-terminus and a Flag tag at the C-terminus. The protein has a calculated MW of 27.0 kDa.

    *The DDM/CHS buffer (Cat. No. DC-11) is sold separately and not included in protein, you can follow the link for product information.

    1. Structure

      Each full-length transmembrane protein is encapsulated by detergent micelle.

    2. Synthesis Process

      Through mild detergent micelle extraction, dedicated solubilization, and stringent affinity purification, we maximally retain the native transmembrane conformation of full-length transmembrane proteins throughout downstream purification. This workflow yields purified, detergent-solubilized proteins free of unrelated membrane impurities and exogenous scaffold proteins, with exceptional purity, accurate quantitation, and well-preserved biological activity—ideal for immunization, binding assays in antibody discovery and screening (ELISA) and affinity testing (SPR and BLI), etc.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Please contact us for detailed information.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Background

The lung-specific splice variant of Claudin-18, forming tight junction strands in alveolar epithelium. It is the dominant isoform in normal lung tissue. Therapeutic targeting focuses exclusively on the cancer-associated Claudin-18.2 isoform, requiring high-specificity antibodies to avoid cross-reactivity and pulmonary toxicity.

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