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Mouse BCMA / TNFRSF17 Protein, His Tag

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Product Number/Spec
Price
Menge
BCA-M52H3-100ug
$360.00
BCA-M52H3-1mg
$2830.00
ETA of in-stock products:2 business days
Gesamtanzahl Product Amount$ 0

Product Details

  • Synonyms

    TNFRSF17, CD269, BCM, BCMA

  • Source

    Mouse BCMA, His Tag (BCA-M52H3) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Thr 49 (Accession # O88472-1).

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  • Molecular Characterization

    BCMA Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 7.5 kDa. The protein migrates as 13 kDa and 14 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Data Display

  • SDS-PAGE

    BCMA SDS-PAGE

    Mouse BCMA, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • Bioactivity-ELISA

     BCMA ELISA

    Immobilized Mouse BCMA, His Tag (Cat. No. BCA-M52H3) at 0.5 μg/mL (100 μL/well) can bind Mouse BAFF, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. BAF-M5257) with a linear range of 0.2-3 ng/mL (QC tested).

    Protocol
  •  BCMA ELISA

    Immobilized Mouse BCMA, His Tag (Cat. No. BCA-M52H3) at 2 μg/mL (100 μL/well) can bind Human BAFF, Fc Tag, active trimer (Cat. No. BAF-H5261) with a linear range of 0.2-6 ng/mL (Routinely tested).

    Protocol
  •  BCMA ELISA

    Immobilized Mouse BCMA, His Tag (Cat. No. BCA-M52H3) at 2 μg/mL (100 μL/well) can bind Human APRIL, Fc Tag with a linear range of 0.1-3 ng/mL (Routinely tested).

    Protocol

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Publish Comment

Background Introduction

Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.

Frontier Progress

 
Drug Development Progress
  • English Name:

    B-cell maturation protein

  • Category:

  • Listed Drugs Count:

    8 Details

  • Clinical Drugs Count:

    145 Details

  • Highest R&D Stage:

    Approved

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