Human Alpha-Synuclein (E46K) Protein, Tag Free

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Cat. No. / Size
Price
Qty
ALN-H5117-200ug
$290.00
ALN-H5117-1mg
$1080.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    SNCA, NACP, PARK1, alpha-Synuclein

  • Source

    Human Alpha-Synuclein (E46K), Tag Free (ALN-H5117) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1 (E46K)).

    Predicted N-terminus: Met 1

    Request for sequence
  • Molecular Characterization

    Alpha-Synuclein Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries no "tag".

    The protein has a calculated MW of 14.5 kDa. The protein migrates as 16 kDa under reducing (R) condition (SDS-PAGE).

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Supplied as 0.2 μm filtered solution in 50mM HEPES, 100mM NaCl, pH8.0 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    Alpha-Synuclein SDS-PAGE

    Human Alpha-Synuclein (E46K), Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • Bioactivity-ELISA

     Alpha-Synuclein ELISA

    Immobilized Human Alpha-Synuclein (E46K), Tag Free (Cat. No. ALN-H5117) at 1 μg/mL (100 μL/well) can bind Synuclein alpha/beta Monoclonal Antibody with a linear range of 0.1-4 ng/mL (QC tested).

    Protocol

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Background

Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.

Recent Advances

 
Drug Development Progress
  • English Name:

    Synuclein alpha

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    25 Details

  • Highest Development Stage:

    Phase 3 Clinical

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