Monoclonal Anti-Human tau Antibody, Mouse IgG1 (6G7C8) (MALS verified)

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Cat. No. / Size
Price
Qty
TAU-MY2102-100ug
$300.00
TAU-MY2102-1mg (500ug X 2)
$2275.00
ETA of in-stock products:2 business days

Product Details

  • Source

    Monoclonal Anti-Human tau Antibody, Mouse IgG1 (6G7C8) is a mouse monoclonal antibody recombinantly expressed in HEK293 cells.

  • Antibody Type

    Recombinant Monoclonal

  • Clone

    6G7C8

  • Isotype

    Mouse IgG1, Kappa

  • Host Species

    Mouse

  • Reactivity

    Human

  • Immunogen

    Recombinant polypeptide protein

  • Specificity

    Specifically recognizes Human p-tau217 Protein.

  • Purification

    Protein A purified / Protein G purified.

  • Aggregation

    Less than 10%, as determined by SEC-MALS.

  • Concentration

    Please refer to the Certificate of Analysis (CoA).

  • Form

    Lyophilized

  • Formulation

    Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Reconstitution

    Please refer to the Certificate of Analysis (CoA) for specific instructions.

  • Shipping

    Lyophilized product is shipped at ambient temperature.

  • Storage

    For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Immunofluorescence

     Tau IMMUNOFLUORESCENCE

    2D cell staining: Immunofluorescent staining (10X) of phosphorylated tau in treated SH-SY5Y neuroblastoma cells with purified TAU-MY2102 at 1:100 dilution. DAPI (blue) was used as nuclear counterstain.

    Protocol
  • Bioactivity-ELISA

     Tau ELISA

    Immobilized Recombinant Human p-Tau217 Protein at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human tau Antibody, Mouse IgG1 (6G7C8) (Cat. No. TAU-MY2102) with a linear range of 0.03-2 ng/mL (QC tested).

    Protocol

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Background

Tau, the microtubule‐associated protein, forms insoluble filaments that accumulate as neurofibrillary tangles in Alzheimer's disease (AD) and related tauopathies. Under physiological conditions, tau regulates the assembly and maintenance of the structural stability of microtubules. In the diseased brain, however, tau becomes abnormally hyperphosphorylated, which ultimately causes the microtubules to disassemble, and the free tau molecules aggregate into paired helical filaments.

Recent Advances

 
Drug Development Progress
  • English Name:

    Microtubule-associated protein tau

  • Category:

  • Approved Drugs:

    1 Details

  • Drugs in Clinical Trials:

    46 Details

  • Highest Development Stage:

    Approved

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