Monoclonal Anti-HRSV Glycoprotein (RSV-G) Antibody, Human IgG1 (8E6) (MALS verified)

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Cat. No. / Size
Price
Qty
RSV-MY2231-100ug
$360.00
RSV-MY2231-1mg (500ug X 2)
$2175.00
ETA of in-stock products:2 business days

Product Details

  • Source

    Monoclonal Anti-HRSV Glycoprotein (RSV-G) Antibody, Human IgG1 (8E6) is a chimeric monoclonal antibody recombinantly expressed in HEK293, which combines the variable region of a mouse monoclonal antibody with human constant domain.

  • Antibody Type

    Recombinant Monoclonal

  • Clone

    8E6

  • Isotype

    Human IgG1, Kappa

  • Host Species

    Mouse

  • Reactivity

    Virus

  • Immunogen

    Recombinant HRSV (A) Glycoprotein G Protein is expressed from human 293 cells

  • Specificity

    Specific recognition of HRSV (A) Glycoprotein G Protein.

  • Cross Verification

    This product No cross-reactivity in ELISA with
    HRSV (A) Glycoprotein G Protein, His Tag (Cat. No. GLG-V5143).
    HRSV (B) Glycoprotein G Protein, His Tag (Cat. No. GLG-V5144).

  • Purification

    Protein A purified / Protein G purified.

  • Aggregation

    Less than 10%, as determined by SEC-MALS.

  • Concentration

    Please refer to the Certificate of Analysis (CoA).

  • Form

    Lyophilized

  • Formulation

    Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Reconstitution

    Please refer to the Certificate of Analysis (CoA) for specific instructions.

  • Shipping

    Lyophilized product is shipped at ambient temperature.

  • Storage

    For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Bioactivity-ELISA

     HRSV Glycoprotein (RSV-G) ELISA

    Immobilized HRSV (A) Glycoprotein G Protein, His Tag (Cat. No. RSG-V5221) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-HRSV Glycoprotein (RSV-G) Antibody, Human IgG1 (8E6) (Cat. No. RSV-MY2231) with a linear range of 0.06-2 ng/mL (QC tested).

    Protocol

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Background

The two major glycoproteins on the surface of the RSV virion, the attachment glycoprotein (G) and the fusion (F) glycoprotein, control the initial phases of infection. The central region of the G protein contains a 13-amino acid highly conserved domain, partially overlapping the cysteine noose domain with 4 cysteines linked 1–4 and 2–3, followed by a highly basic heparin-binding domain (HBD). The HBD is the likely attachment site for heparan sulfate (HS) found on the surface of most cells. A peptide from the G protein HBD (amino acids 184–198) binds efficiently to HEp-2 cells and inhibits RSV infection.

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