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Product Details
Background
Recombinant Monoclonal Anti-CD45(LCA) Antibody, Rabbit (1C3) is a CD45(LCA) primary antibody for IHC application. Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
Product Specifications
Host SpeciesRabbitIsotypeRabbit IgG, Rabbit KappaClone1C3ApplicationIHC-PDilution Ratio1: 500 - 1: 2000FormLiquidClonalityMonoclonalReactivityHumanSynonymsPTPRC, CD45, GP180, LCA, T200Concentration0.9~1.1 mg/mlSpecificityReact with CD45(LCA) protein on the membrane of target cell/tissuePurification TechProtein APreservationPBS, BSA, GlycerolExperiment Protocol
Storage
Shipped at 4°C, Blue Ice. Store at +4°C for short term (1-2 weeks). Store at -20°C for long term.
Avoid freeze / thaw cycle. Upon delivery aliquot. The shelf life is 30 days from the date of opening.ACRO Quality Management System
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Sample Staining Data
Immunohistochemical analysis of paraffin embedded human cancer tissue labelled with HGS-S261 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
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