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Product Details
Background
Recombinant Monoclonal Anti-CD19 Antibody, Rabbit (4A6) is a CD19 primary antibody for IHC application. Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges. Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge.
Product Specifications
Host SpeciesRabbitIsotypeRabbit IgG, Rabbit KappaClone4A6ApplicationIHC-PDilution Ratio1: 500 - 1: 2000FormLiquidClonalityMonoclonalReactivityHumanSynonymsLeu-12Concentration0.9~1.1 mg/mlSpecificityReact with CD19 protein on the membrane of target cell/tissuePurification TechProtein APreservationPBS, BSA, GlycerolExperiment Protocol
Storage
Shipped at 4°C, Blue Ice. Store at +4°C for short term (1-2 weeks). Store at -20°C for long term.
Avoid freeze / thaw cycle. Upon delivery aliquot. The shelf life is 30 days from the date of opening.ACRO Quality Management System
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Sample Staining Data
Immunohistochemical analysis of paraffin embedded human cancer tissue labelled with HGS-S259 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
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Frontier Progress
Drug Development Progress- English Name：
B-lymphocyte antigen CD19
- Category：
- Listed Drugs Count：
14 Details
- Clinical Drugs Count：
435 Details
- Highest R&D Stage：
Approved
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