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PE-Labeled Monoclonal Anti-Human CD159a / NKG2A Antibody, Mouse IgG1 (AS680) (0.03% Proclin)

COADS MS
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FABm069-01-100tests (50tests X 2)
$350.00
ETA of in-stock products:2 business days
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Product Details

  • Source

    Monoclonal Anti-Human CD159a/NKG2A Antibody, Mouse IgG1(AS680) is a mouse monoclonal antibody, which provides higher batch consistency and long term security of supply.

  • Clone

    AS680

  • Isotype

    Mouse IgG1, Kappa

  • Host Species

    Mouse

  • Reactivity

    Human

  • Immunogen

    CD159a/NKG2A

  • Conjugate

    PE

    Excitation Wavelength: 488 nm / 561 nm

    Emission Wavelength: 575 nm

  • Specificity

    This product is a specific antibody specifically reacts with CD159a/NKG2A epsilon protein.

  • Application

    Flow Cytometry (Evaluation of the expression of CD159a/NKG2A on Human cells).

  • Recommended Dilution

    1:20

  • Isotype Control

    The isotype control is sold separately; please refer to Cat. No. DNP-PM1 for product information.

  • Form

    Liquid

  • Formulation

    Supplied as 0.2 μm-filtered solution in PBS (pH 7.4) containing 0.03% ProClin 300 and 0.2% BSA, with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Shipping

    Liquid product is shipped at blue ice.

  • Storage

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. Store at 2-8 °C for 12 months.

  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Bioactivity-FACS

    CD159a FACS

    Flow cytometric analysis of NK92 staining PE-Labeled Monoclonal Anti-Human CD159a/NKG2A Antibody, MouseIgG1 (AS680) (Cat. No. FABm069-01) at 1:20 dilution (5 μL of the antibody stock solution corresponds to labeling of 1×10⁶ cells in a final volume of 100 µL), compared with isotype control antibody. PE signal was used to evaluate the binding activity (QC tested).

    Protocol

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Background

NKG2A/CD159a is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors that inhibits innate immune system activation, also known as KLRC1, CD159a, NK cell receptor A and NKG2-A/NKG2-B type II integral membrane protein. NKG2A marks a unique immune effector subset preferentially co-expressing the tissue-resident CD103 molecule, but not immune checkpoint inhibitors. NKG2A blockade therapy operated through CD8 T cells, but not NK cells. The increase in NKG2A expression might be induced by IL-10, which was present at a high level in the plasma of HCC patients. Blocking IL-10 could specifically inhibit NKG2A expression in NK cells. These findings indicate that NKG2A expression is influenced by factors from cancer nests and contributes to NK cell exhaustion, suggesting that NKG2A blockade has the potential to restore immunity against liver tumors by reversing NK cell exhaustion.

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