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Product Details
Background
Recombinant Monoclonal Anti-C-MET Antibody, Rabbit (1A1) is a C-MET primary antibody for IHC application. MET is a tyrosine kinase receptor for the hepatocyte growth factor. It is linked to functions such as cell proliferation, scattering, morphogenesis, and survival. Ligand binding at the cell surface induces autophosphorylation of MET that provides docking sites for downstream signaling molecules. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation.
Product Specifications
Host SpeciesRabbitIsotypeRabbit IgG, Rabbit KappaClone1A1ApplicationIHC-PDilution Ratio1: 500 - 1: 2000FormLiquidClonalityMonoclonalReactivityHumanSynonymsMETConcentration0.9~1.1 mg/mlSpecificityReact with C-MET protein on the membrane of target cell/tissuePurification TechProtein APreservationPBS, BSA, GlycerolExperiment Protocol
Storage
Shipped at 4°C, Blue Ice. Store at +4°C for short term (1-2 weeks). Store at -20°C for long term.
Avoid freeze / thaw cycle. Upon delivery aliquot. The shelf life is 30 days from the date of opening.ACRO Quality Management System
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Sample Staining Data
Immunohistochemical analysis of paraffin embedded human cancer tissue labelled with HGS-S303 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
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Frontier Progress
Drug Development Progress- English Name：
Hepatocyte growth factor receptor
- Category：
- Listed Drugs Count：
13 Details
- Clinical Drugs Count：
74 Details
- Highest R&D Stage：
Approved
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